Cylicin-2 Activators
Cyclin-2 activators are compounds that indirectly influence the function and stability of Cylicin-2 through modulation of cellular pathways and cytoskeletal dynamics. These chemicals operate by affecting the phosphorylation state of proteins, altering secondary messenger levels, or impacting cytoskeletal integrity. For instance, cAMP and forskolin may indirectly modulate Cylicin-2 activity by enhancing PKA activity, leading to the phosphorylation of proteins that either regulate or interact with Cylicin-2, thus impacting its function in the sperm head cytoskeleton. Similarly, PMA activates PKC, which could also lead to phosphorylation changes in the cytoskeletal network associated with Cylicin-2.
Compounds like lithium chloride and okadaic acid offer insight into the phosphorylation balance that governs protein interactions and stability, suggesting that inhibiting GSK-3 or protein phosphatases could alter the state of proteins that affect Cylicin-2's role. Calcium signaling, influenced by ionomycin, can initiate a cascade that impacts protein kinases and cytoskeletal organization, thus potentially affecting Cylicin-2 indirectly. Cytoskeletal disruptors and stabilizers like jasplakinolide reshape the cellular architecture, which could influence Cylicin-2's cytoskeletal association.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Adenosine 3′,5′-cyclic monophosphate | 60-92-4 | sc-217584 sc-217584A sc-217584B sc-217584C sc-217584D sc-217584E | 100 mg 250 mg 5 g 10 g 25 g 50 g | $114.00 $175.00 $260.00 $362.00 $617.00 $1127.00 | ||
As a secondary messenger, it can modulate protein kinase A (PKA) activity, which may phosphorylate proteins that interact with or regulate Cylicin-2. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
An activator of protein kinase C (PKC) that can phosphorylate proteins in the cytoskeletal network, potentially influencing Cylicin-2's function or stability. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
An activator of adenylate cyclase, increasing cAMP levels and thereby activating PKA, which could impact Cylicin-2 indirectly through phosphorylation cascades. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
A calcium ionophore that raises intracellular calcium levels, possibly affecting calcium-dependent protein kinases and thereby Cylicin-2’s association with the cytoskeleton. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Inhibits glycogen synthase kinase 3 (GSK-3), which may affect the phosphorylation state of proteins associated with Cylicin-2. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $285.00 $520.00 $1300.00 | 78 | |
A potent inhibitor of protein phosphatases PP1 and PP2A, altering the phosphorylation state of cytoskeletal proteins and possibly affecting Cylicin-2's role. | ||||||
Calyculin A | 101932-71-2 | sc-24000 sc-24000A sc-24000C | 10 µg 100 µg 1 mg | $160.00 $750.00 $3000.00 | 59 | |
Another inhibitor of PP1 and PP2A, potentially altering the phosphorylation dynamics of proteins that interact with Cylicin-2. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $47.00 | ||
Zinc can stabilize cellular structures and proteins; thus, it may enhance the stability or function of Cylicin-2 indirectly. | ||||||
Magnesium chloride | 7786-30-3 | sc-255260C sc-255260B sc-255260 sc-255260A | 10 g 25 g 100 g 500 g | $27.00 $34.00 $47.00 $123.00 | 2 | |
Required for ATPase activity, could support energy-dependent processes that modulate Cylicin-2's function. | ||||||
Jasplakinolide | 102396-24-7 | sc-202191 sc-202191A | 50 µg 100 µg | $180.00 $299.00 | 59 | |
Stabilizes actin filaments, and could indirectly influence the structural context in which Cylicin-2 operates. | ||||||