Date published: 2025-9-26

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cyclin E Inhibitors

Cyclin E inhibitors constitute a significant chemical class with crucial implications in cell cycle regulation. These compounds interact intricately with cyclin E, a key protein involved in cell cycle progression. Cyclin E forms a complex with cyclin-dependent kinases (CDKs), orchestrating the transition from G1 phase to S phase in the cell cycle. The inhibitors targeting cyclin E function by impeding the binding of cyclin E to its corresponding CDK partner, thereby interrupting the initiation of DNA replication. This interference halts the progression of the cell cycle at a pivotal checkpoint, serving as a regulatory mechanism to prevent uncontrolled cell division and maintain genomic stability. The molecular structure of cyclin E inhibitors typically features distinct functional groups that engage with the binding sites of cyclin E and CDK. These inhibitors exert their effects through a competitive inhibition mechanism, where they vie with cyclin E for binding to the CDK active site. By obstructing this interaction, cyclin E inhibitors play a pivotal role in modulating the orderly progression of the cell cycle. Their influence extends beyond a single phase, as the cell cycle requires meticulous coordination of various checkpoints to ensure accurate DNA replication and cell division. In essence, cyclin E inhibitors act as molecular brakes, restraining the cell cycle machinery at specific stages and helping to prevent aberrant proliferation that could have wide-ranging implications for cellular health.

Items 11 to 20 of 21 total

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Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Dinaciclib

779353-01-4sc-364483
sc-364483A
5 mg
25 mg
$242.00
$871.00
1
(0)

Dinaciclib is a broad-spectrum CDK inhibitor, affecting multiple CDKs including CDK1 and CDK2, leading to cell cycle arrest.

Indirubin-3′-monoxime

160807-49-8sc-202660
sc-202660A
sc-202660B
1 mg
5 mg
50 mg
$77.00
$315.00
$658.00
1
(1)

Indirubin-3'-monoxime (CAS 160807-49-8) is a chemical compound known for its role as a cyclin E inhibitor, affecting cell cycle processes. It interacts with cyclin E, influencing cellular mechanisms.

Indirubin-5-sulfonic acid sodium salt

sc-221755
sc-221755A
1 mg
5 mg
$57.00
$324.00
(0)

Indirubin-5-sulfonic acid sodium salt exhibits a unique affinity for cyclin E, modulating its activity through specific hydrogen bonding and hydrophobic interactions. This compound influences the phosphorylation state of cyclin E, thereby affecting its interaction with cyclin-dependent kinases. Its distinct sulfonic acid group enhances solubility and reactivity, allowing for rapid engagement in cellular signaling pathways. The compound's kinetic behavior reveals a sophisticated mechanism of action, contributing to the regulation of cell cycle progression.

Oxindole I

sc-222104
10 mg
$273.00
2
(0)

Oxindole I demonstrates a remarkable ability to interact with cyclin E, primarily through π-π stacking and van der Waals forces. This compound alters the conformational dynamics of cyclin E, influencing its stability and interaction with cyclin-dependent kinases. Its unique structural features facilitate selective binding, leading to modulation of downstream signaling pathways. The compound's reactivity profile showcases its potential to engage in complex biochemical networks, impacting cellular proliferation and differentiation.

AT7519

844442-38-2sc-364416
sc-364416A
sc-364416B
sc-364416C
5 mg
10 mg
100 mg
1 g
$207.00
$246.00
$1025.00
$3065.00
1
(0)

AT7519 is a multi-CDK inhibitor, including CDK4 and CDK6, as well as other kinases.

PNU 112455A hydrochloride

21886-12-4sc-222182
sc-222182A
1 mg
5 mg
$82.00
$106.00
(0)

PNU 112455A hydrochloride (CAS 21886-12-4) is a chemical compound known for its role as a cyclin E inhibitor. It has been studied for its impact on cell cycle regulation.

Aurora Kinase/Cdk Inhibitor

443797-96-4sc-203829
5 mg
$440.00
(0)

The chemical compound "Aurora Kinase/Cdk Inhibitor" (CAS 443797-96-4) functions as a cyclin E inhibitor, affecting cell cycle regulation. It modulates specific cellular processes by targeting relevant kinases.

CR8, (S)-Isomer

1084893-56-0sc-311307
5 mg
$201.00
(0)

CR8, (S)-Isomer (CAS 1084893-56-0) is a chemical compound known for its role as a potent inhibitor of cyclin E. It has shown the ability to modulate cellular processes through its interaction with cyclin E.

P276-00

920113-03-7sc-477932
1 mg
$380.00
(0)

P276-00 is a novel CDK inhibitor that targets CDK1, CDK2, and CDKIt has shown anti-cancer activity in research studies.

SU 9516

377090-84-1sc-222330
sc-222330A
5 mg
25 mg
$122.00
$383.00
3
(1)

SU9516 is a selective CDK2 inhibitor that interferes with the activity of cyclin E-CDK2 complexes, thus blocking cell cycle progression. It's been studied as a potential anti-cancer agent.