CUL-5 Inhibitors
CUL-5 inhibitors belong to a class of chemical compounds that target the Cullin-5 (CUL-5) protein within the ubiquitin-proteasome system, which plays a pivotal role in the regulation of protein degradation in eukaryotic cells. The CUL-5 protein serves as a scaffold within the Cullin-RING E3 ligase complex, facilitating the ubiquitination and subsequent degradation of specific target proteins. Inhibitors of CUL-5 function are designed to disrupt this process, thereby modulating the stability and abundance of specific proteins within the cell.
The ubiquitin-proteasome system is essential for maintaining cellular homeostasis by regulating the turnover of various proteins, including those involved in cell cycle control, DNA repair, and signal transduction pathways. CUL-5 inhibitors typically function by interfering with the assembly or stability of the Cullin-RING E3 ligase complex, preventing the ubiquitination and degradation of target proteins. This class of compounds has gained significant attention in research and drug discovery efforts due to its ability to modulate key cellular processes and pathways. By selectively inhibiting CUL-5, researchers aim to gain a deeper understanding of the intricate regulatory mechanisms within the ubiquitin-proteasome system.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Fluorouracil | 51-21-8 | sc-29060 sc-29060A | 1 g 5 g | $37.00 $152.00 | 11 | |
Fluorouracil may inhibit the expression of CUL-5 as it interferes with DNA synthesis and cellular replication, potentially affecting the transcription and translation processes necessary for CUL-5 production. | ||||||
Cisplatin | 15663-27-1 | sc-200896 sc-200896A | 100 mg 500 mg | $138.00 $380.00 | 101 | |
Cisplatin forms DNA adducts, disrupting DNA function and potentially leading to reduced expression of various proteins, including CUL-5. | ||||||
Doxorubicin | 23214-92-8 | sc-280681 sc-280681A | 1 mg 5 mg | $176.00 $426.00 | 43 | |
Doxorubicin hydrochloride intercalates into DNA, which can disrupt the transcriptional machinery and potentially decrease the expression of CUL-5. | ||||||
Etoposide (VP-16) | 33419-42-0 | sc-3512B sc-3512 sc-3512A | 10 mg 100 mg 500 mg | $51.00 $231.00 $523.00 | 63 | |
Etoposide stabilizes the DNA-topoisomerase II complex, leading to DNA breaks. This can affect the transcription and translation processes, potentially reducing CUL-5 expression. | ||||||
Methotrexate | 59-05-2 | sc-3507 sc-3507A | 100 mg 500 mg | $94.00 $213.00 | 33 | |
Methotrexate is an antimetabolite that inhibits dihydrofolate reductase, affecting DNA synthesis and cell replication. This could lead to reduced CUL-5 expression. | ||||||
Camptothecin | 7689-03-4 | sc-200871 sc-200871A sc-200871B | 50 mg 250 mg 100 mg | $58.00 $186.00 $94.00 | 21 | |
Camptothecin inhibits topoisomerase I, leading to DNA damage and potentially affecting the expression of various proteins including CUL-5. | ||||||
Bleomycin Sulfate | 9041-93-4 | sc-200134 sc-200134A sc-200134B sc-200134C | 10 mg 50 mg 100 mg 500 mg | $210.00 $624.00 $1040.00 $2913.00 | 38 | |
Bleomycin Sulfate induces DNA strand breaks, potentially disrupting the transcription and translation processes required for CUL-5 expression. | ||||||
Hydroxyurea | 127-07-1 | sc-29061 sc-29061A | 5 g 25 g | $78.00 $260.00 | 18 | |
Hydroxyurea inhibits ribonucleotide reductase, affecting DNA synthesis. This could lead to a decrease in CUL-5 expression. | ||||||
Actinomycin D | 50-76-0 | sc-200906 sc-200906A sc-200906B sc-200906C sc-200906D | 5 mg 25 mg 100 mg 1 g 10 g | $74.00 $243.00 $731.00 $2572.00 $21848.00 | 53 | |
Actinomycin D intercalates into DNA and disrupts the transcription process. This can lead to reduced expression of various proteins, including CUL-5. | ||||||
Taxol | 33069-62-4 | sc-201439D sc-201439 sc-201439A sc-201439E sc-201439B sc-201439C | 1 mg 5 mg 25 mg 100 mg 250 mg 1 g | $41.00 $74.00 $221.00 $247.00 $738.00 $1220.00 | 39 | |
Taxol stabilizes microtubules, potentially affecting cellular processes and protein expression, including that of CUL-5. | ||||||