CTLA-2α Activators
CTLA-2α, predicted to enable cysteine-type endopeptidase activity, acts upstream of or within negative regulation of the inflammatory response, protein processing, and regulatory T cell differentiation. Located in dendrites, it is expressed in various structures, indicating its multifaceted role in immune regulation. Activation of CTLA-2α involves both direct and indirect mechanisms. Direct activators, such as LPS and PMA, directly impact CTLA-2α by inducing inflammatory responses and modulating protein processing and regulatory T cell differentiation. Indirectly, chemicals like dexamethasone and TGF-β modulate inflammatory responses and regulatory T cell differentiation, enhancing CTLA-2α activity.
For example, LPS directly activates CTLA-2α by acting as a TLR4 agonist, inducing an inflammatory response and influencing negative regulation of inflammatory responses and regulatory T cell differentiation. This multifaceted activation contributes to CTLA-2α's role in immune regulation, making it a crucial player in maintaining immune homeostasis and responding to challenges. Understanding these complex interactions provides insights into the regulatory network governing CTLA-2α activation and its broader implications in immune physiology.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Lipopolysaccharide, E. coli O55:B5 | 93572-42-0 | sc-221855 sc-221855A sc-221855B sc-221855C | 10 mg 25 mg 100 mg 500 mg | $98.00 $171.00 $425.00 $1560.00 | 12 | |
TLR4 agonist directly activating CTLA-2α. Induces inflammatory response, potentially enhancing CTLA-2α activity in negative regulation of the inflammatory response. Modulates protein processing and regulatory T cell differentiation, contributing to CTLA-2α's multifaceted role. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $91.00 $139.00 $374.00 | 36 | |
Glucocorticoid receptor activator indirectly influencing CTLA-2α. Suppresses inflammatory response, potentially enhancing CTLA-2α activity. Modulates protein processing and regulatory T cell differentiation, contributing to CTLA-2α's multifaceted role. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PKC activator directly activating CTLA-2α. Modulates protein processing, potentially enhancing CTLA-2α activity. Influences negative regulation of inflammatory response and regulatory T cell differentiation, contributing to CTLA-2α's multifaceted role. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
NF-κB inhibitor indirectly influencing CTLA-2α. Suppresses inflammatory response, potentially enhancing CTLA-2α activity. Modulates protein processing and regulatory T cell differentiation, contributing to CTLA-2α's multifaceted role in immune regulation. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
mTOR inhibitor indirectly impacting CTLA-2α. Modulates regulatory T cell differentiation, potentially enhancing CTLA-2α activity. Influences protein processing and negative regulation of inflammatory response, contributing to CTLA-2α's multifaceted role in immune regulation. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $90.00 $349.00 | 284 | |
p38 MAPK inhibitor indirectly influencing CTLA-2α. Modulates inflammatory response, potentially enhancing CTLA-2α activity. Influences protein processing and regulatory T cell differentiation, contributing to CTLA-2α's multifaceted role in immune regulation. | ||||||
α-Lipoic Acid | 1077-28-7 | sc-202032 sc-202032A sc-202032B sc-202032C sc-202032D | 5 g 10 g 250 g 500 g 1 kg | $69.00 $122.00 $212.00 $380.00 $716.00 | 3 | |
Antioxidant indirectly impacting CTLA-2α. Modulates inflammatory response, potentially enhancing CTLA-2α activity. Influences protein processing and regulatory T cell differentiation, contributing to CTLA-2α's multifaceted role in immune regulation. | ||||||
Cholecalciferol | 67-97-0 | sc-205630 sc-205630A sc-205630B | 1 g 5 g 10 g | $71.00 $163.00 $296.00 | 2 | |
Cholecalciferol modulates regulatory T cell differentiation, potentially enhancing CTLA-2α activity. Influences protein processing and negative regulation of inflammatory response, contributing to CTLA-2α's multifaceted role in immune regulation. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
PI3K inhibitor indirectly impacting CTLA-2α. Modulates regulatory T cell differentiation, potentially enhancing CTLA-2α activity. Influences protein processing and negative regulation of inflammatory response, contributing to CTLA-2α's multifaceted role in immune regulation. | ||||||