CstF-50 Activators
CstF-50, formally known as Cleavage stimulation factor 50 kDa subunit, is a crucial protein in the process of mRNA 3' end formation in eukaryotic cells. This protein, encoded by the CSTF1 gene, is part of the cleavage stimulation factor (CstF) complex, a key player in the pre-mRNA cleavage and polyadenylation process. The CstF complex itself is typically composed of three subunits: CstF-77, CstF-64, and CstF-50, with CstF-50 being essential for the complex's stability and function.
The primary role of CstF-50 is to participate in the cleavage of pre-mRNA and the addition of a poly(A) tail at the 3' end. This modification is a critical step in mRNA maturation and is essential for the stability, nuclear export, and translation of mRNA molecules. By influencing the polyadenylation process, CstF-50 indirectly affects gene expression regulation.CstF-50 also interacts with other proteins and RNA elements to modulate the cleavage and polyadenylation specificity factor (CPSF) complex, another critical component in the polyadenylation machinery. Through these interactions, CstF-50 helps determine the specific sites where pre-mRNA will be cleaved and polyadenylated, impacting the generation of different mRNA isoforms through alternative polyadenylation. This process is vital for the regulation of gene expression in various developmental and cellular contexts.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
DRB | 53-85-0 | sc-200581 sc-200581A sc-200581B sc-200581C | 10 mg 50 mg 100 mg 250 mg | $43.00 $189.00 $316.00 $663.00 | 6 | |
DRB is a potent inhibitor of RNA polymerase II. By inhibiting transcription, it can indirectly affect mRNA processing mechanisms, potentially influencing CstF-50 activity. | ||||||
Spliceostatin A | 391611-36-2 | sc-507481 | 1 mg | $1800.00 | ||
This compound is a potent inhibitor of the spliceosome, affecting RNA splicing. Altered splicing can indirectly impact mRNA 3' end processing, where CstF-50 is involved. | ||||||
Leptomycin B | 87081-35-4 | sc-358688 sc-358688A sc-358688B | 50 µg 500 µg 2.5 mg | $107.00 $416.00 $1248.00 | 35 | |
Known as an inhibitor of nuclear export, it affects mRNA transport and processing, potentially altering CstF-50 related pathways. | ||||||
Actinomycin D | 50-76-0 | sc-200906 sc-200906A sc-200906B sc-200906C sc-200906D | 5 mg 25 mg 100 mg 1 g 10 g | $74.00 $243.00 $731.00 $2572.00 $21848.00 | 53 | |
This antibiotic intercalates DNA and inhibits RNA polymerase, thereby indirectly influencing mRNA processing and potentially CstF-50 activity. | ||||||
Triptolide | 38748-32-2 | sc-200122 sc-200122A | 1 mg 5 mg | $90.00 $204.00 | 13 | |
Triptolide is known to inhibit RNA Polymerase II, thereby impacting transcription and indirectly mRNA processing mechanisms. | ||||||
Flavopiridol Hydrochloride | 131740-09-5 | sc-207687 | 10 mg | $317.00 | ||
As a cyclin-dependent kinase inhibitor, Flavopiridol can affect transcription regulation, indirectly impacting CstF-50 activity. | ||||||
Rocaglamide | 84573-16-0 | sc-203241 sc-203241A sc-203241B sc-203241C sc-203241D | 100 µg 1 mg 5 mg 10 mg 25 mg | $275.00 $474.00 $1639.00 $2497.00 $5344.00 | 4 | |
Rocaglamide inhibits translation and can also indirectly affect mRNA processing, potentially influencing CstF-50. | ||||||
KPT 330 | 1393477-72-9 | sc-489062 | 5 mg | $173.00 | ||
As a selective inhibitor of nuclear export, it affects mRNA processing, potentially impacting CstF-50 activity. | ||||||
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $99.00 $259.00 | 36 | |
Known as a protein synthesis inhibitor, it can indirectly influence mRNA processing, affecting CstF-50. | ||||||
Tunicamycin | 11089-65-9 | sc-3506A sc-3506 | 5 mg 10 mg | $172.00 $305.00 | 66 | |
Tunicamycin inhibits N-linked glycosylation, affecting overall cellular processes, including mRNA processing that involves CstF-50. | ||||||