CST Inhibitors
CST inhibitors are chemical compounds that specifically target and inhibit the function of CST (CST complex), a protein complex that plays a critical role in telomere maintenance and DNA replication. The CST complex, composed of CTC1, STN1, and TEN1, is essential for protecting telomeres and facilitating the proper replication of chromosome ends. Telomeres, which are repetitive nucleotide sequences at the ends of chromosomes, prevent the loss of essential genetic information during cell division. The CST complex ensures that telomeres are adequately replicated, particularly by coordinating the final steps of telomere replication, where traditional replication machinery struggles to complete the process. CST acts as a single-strand DNA-binding protein, stabilizing the telomere ends and preventing them from being recognized as damaged DNA.
Inhibitors of CST disrupt the function of the complex by blocking its ability to bind to telomeric DNA or interfering with its interactions within the complex itself. These inhibitors may target specific binding domains within the CTC1, STN1, or TEN1 components, preventing the CST complex from performing its protective role at telomeres. By inhibiting CST, researchers can study its direct role in telomere length regulation and the broader implications of telomere stability on genome integrity. Disrupting CST function can lead to improper replication of telomeres, exposing the effects of telomere shortening and genomic instability, which are critical factors in cellular aging and DNA damage responses. CST inhibitors thus serve as important tools for investigating the cellular mechanisms that safeguard chromosome ends and maintain genetic stability during cell division.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Leupeptin hemisulfate | 103476-89-7 | sc-295358 sc-295358A sc-295358D sc-295358E sc-295358B sc-295358C | 5 mg 25 mg 50 mg 100 mg 500 mg 10 mg | $72.00 $145.00 $265.00 $489.00 $1399.00 $99.00 | 19 | |
Leupeptin is a reversible inhibitor of serine and cysteine proteases. It forms a stable complex with the enzyme, thereby inhibiting its activity. | ||||||
CA-074 | 134448-10-5 | sc-202513 | 1 mg | $315.00 | ||
CA-074 is a selective, irreversible inhibitor of cathepsin B, which is a target of CST inhibition. It binds covalently to the active site of the enzyme. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $56.00 $260.00 $980.00 | 163 | |
MG-132 is a potent, reversible proteasome and calpain inhibitor, affecting the ubiquitin-proteasome pathway, which is indirectly related to CST function. | ||||||
Lactacystin | 133343-34-7 | sc-3575 sc-3575A | 200 µg 1 mg | $165.00 $575.00 | 60 | |
Lactacystin is a specific inhibitor of the 20S proteasome, indirectly influencing CST-related proteolytic processes. | ||||||
Z-FA-FMK | 197855-65-5 | sc-201303 sc-201303A | 1 mg 5 mg | $125.00 $365.00 | 19 | |
Z-FA-FMK is a broad-spectrum inhibitor of cysteine proteases, including those inhibited by CST, functioning through irreversible binding. | ||||||
VX-765 | 273404-37-8 | sc-475845 sc-475845A sc-475845B | 5 mg 10 mg 50 mg | $224.00 $296.00 $949.00 | 1 | |
VX-765 is a bioavailable compound of VRT-043198, a selective inhibitor of caspase-1, indirectly related to CST inhibition. | ||||||
Alloxan monohydrate | 2244-11-3 | sc-254940 | 10 g | $53.00 | ||
Alloxan is a compound known to induce diabetes in animal models, indirectly affecting protease activity and thus CST functions. | ||||||
E-64 | 66701-25-5 | sc-201276 sc-201276A sc-201276B | 5 mg 25 mg 250 mg | $275.00 $928.00 $1543.00 | 14 | |
E-64 is a potent, irreversible inhibitor of cysteine proteases. It covalently binds to the active thiol group in these enzymes, effectively inhibiting their activity. | ||||||
Odanacatib | 603139-19-1 | sc-364675 sc-364675A sc-364675B | 5 mg 25 mg 250 mg | $214.00 $974.00 $1943.00 | 2 | |
Odanacatib is a selective and reversible inhibitor of cathepsin K, indirectly related to CST inhibition by targeting similar proteolytic pathways. | ||||||