Date published: 2026-4-1

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CSAGE Activators

CSAGE, or Capture Selective Amplify and Gate, is a cutting-edge molecular biology technique designed to selectively target and analyze specific RNA transcripts from a complex mixture of RNA molecules. This method is particularly useful in transcriptomics, where it aids in the study of gene expression and regulation.The CSAGE technique involves several key steps. First, it uses molecular "capture" probes that are designed to specifically bind to the RNA transcripts of interest. These probes are typically short, complementary DNA or RNA sequences tailored to match the target RNA. Once bound, these probes allow for the selective isolation of the desired RNA from a complex sample, such as a cell or tissue extract.

Following capture, the targeted RNA undergoes an amplification process. This step is crucial because it increases the quantity of the RNA of interest, making it more detectable and analyzable. Amplification is typically achieved through techniques like PCR (Polymerase Chain Reaction), which can efficiently replicate specific RNA sequences.The final step, "gate," refers to the analysis and quantification of the amplified RNA. This can be done through various methods, such as sequencing or hybridization-based approaches. The data obtained provide insights into the abundance and variants of the targeted RNA transcripts, offering valuable information about gene expression patterns and regulation mechanisms. CSAGE is particularly advantageous in scenarios where precise and selective analysis of specific RNA molecules is required. It is used in research areas like cancer biology, developmental biology, and neuroscience, helping scientists understand complex gene expression dynamics in health and disease.

SEE ALSO...

Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

5-Azacytidine

320-67-2sc-221003
500 mg
$280.00
4
(1)

A DNA methyltransferase inhibitor, 5-Azacytidine can reactivate silenced genes in cancer cells, potentially affecting CSAGE expression or activity.

Trichostatin A

58880-19-6sc-3511
sc-3511A
sc-3511B
sc-3511C
sc-3511D
1 mg
5 mg
10 mg
25 mg
50 mg
$152.00
$479.00
$632.00
$1223.00
$2132.00
33
(3)

A histone deacetylase inhibitor, Trichostatin A changes chromatin structure and may indirectly influence CSAGE expression.

Suberoylanilide Hydroxamic Acid

149647-78-9sc-220139
sc-220139A
100 mg
500 mg
$133.00
$275.00
37
(2)

Similar to Trichostatin A, Vorinostat is a histone deacetylase inhibitor that could indirectly affect CSAGE by altering gene expression.

Cisplatin

15663-27-1sc-200896
sc-200896A
100 mg
500 mg
$138.00
$380.00
101
(4)

A chemotherapy drug, Cisplatin induces DNA damage, which could indirectly influence CSAGE expression or activity in cancer cells.

Doxorubicin

23214-92-8sc-280681
sc-280681A
1 mg
5 mg
$176.00
$426.00
43
(3)

An anthracycline antibiotic used in cancer chemotherapy, Doxorubicin might affect CSAGE-expressing cells by inducing DNA damage and apoptosis.

Rapamycin

53123-88-9sc-3504
sc-3504A
sc-3504B
1 mg
5 mg
25 mg
$63.00
$158.00
$326.00
233
(4)

An mTOR inhibitor, Rapamycin can modulate cell growth and proliferation, potentially affecting CSAGE function in cancer cells.