CRIF1 Inhibitors
CRIF1 (CR6-Interacting Factor 1), serving as a linchpin within the mitochondrial oxidative phosphorylation (OXPHOS) system, is crucial for the integration of mitochondrial DNA-encoded polypeptides into the mitochondrial membrane. This function is paramount for the proper assembly and operation of the OXPHOS complexes, which are integral for cellular energy production. By facilitating the precise assembly of these complexes, CRIF1 not only supports the efficient production of ATP but also plays a significant role in maintaining mitochondrial and cellular homeostasis. The inhibition of CRIF1 can disrupt these processes, leading to compromised mitochondrial function, reduced ATP production, and perturbed cellular energy balance. This disruption can have profound effects on cell growth, differentiation, and survival, given the central role of mitochondria in energy metabolism, reactive oxygen species (ROS) regulation, and apoptosis.
The mechanisms underlying the inhibition of CRIF1 function are multifaceted and can occur at various levels, including transcriptional repression, post-translational modifications, and interference with CRIF1's mitochondrial localization or its interaction with mitochondrial ribosomes. Transcriptional downregulation of CRIF1 can result from signaling pathways responsive to cellular stress or altered metabolic states, which may deemphasize mitochondrial biogenesis or OXPHOS assembly in favor of survival pathways. Post-translational modifications such as phosphorylation, ubiquitination, or acetylation can alter CRIF1's stability, its capacity to interact with key mitochondrial components, or its ability to be properly localized within the mitochondria. Additionally, factors that disrupt the interaction between CRIF1 and mitochondrial ribosomal proteins can impede the assembly of the OXPHOS complexes by preventing the proper insertion of mitochondrial-encoded polypeptides into the mitochondrial membrane. Such inhibition of CRIF1's function reflects a regulatory mechanism by which cells can modulate mitochondrial activity and energy production in response to changing environmental conditions and cellular demands, thereby maintaining energy homeostasis and adapting to metabolic stress.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Actinomycin D | 50-76-0 | sc-200906 sc-200906A sc-200906B sc-200906C sc-200906D | 5 mg 25 mg 100 mg 1 g 10 g | $74.00 $243.00 $731.00 $2572.00 $21848.00 | 53 | |
Actinomycin D is an antibiotic that inhibits transcription by binding to DNA and preventing RNA synthesis. Its inhibition of transcription influences the expression of genes, including those involved in pathways where CRIF1 plays a role. The indirect impact on CRIF1 expression affects its cellular functions, potentially leading to modulation or inhibition. | ||||||
2-Deoxy-D-glucose | 154-17-6 | sc-202010 sc-202010A | 1 g 5 g | $70.00 $215.00 | 26 | |
2-Deoxy-D-glucose is a glucose analog that competitively inhibits glucose metabolism. By interfering with glycolysis, it indirectly influences pathways that may affect CRIF1 function. The alteration in energy metabolism can lead to changes in cellular processes where CRIF1 is involved, contributing to its modulation or inhibition. | ||||||
Metformin | 657-24-9 | sc-507370 | 10 mg | $79.00 | 2 | |
Metformin is an anti-diabetic drug that activates AMP-activated protein kinase (AMPK), impacting cellular energy metabolism. The activation of AMPK can indirectly influence CRIF1 function, as CRIF1 is involved in cellular responses to metabolic stress. The modulation of CRIF1 through AMPK activation may lead to downstream effects on cellular processes where CRIF1 plays a role, potentially resulting in its inhibition. | ||||||
Rotenone | 83-79-4 | sc-203242 sc-203242A | 1 g 5 g | $89.00 $259.00 | 41 | |
Rotenone is a mitochondrial complex I inhibitor that disrupts electron transport and energy production. The impact on mitochondrial function indirectly affects pathways involving CRIF1, as CRIF1 is associated with mitochondrial processes. The modulation of CRIF1 through mitochondrial dysfunction can lead to downstream effects on cellular processes where CRIF1 plays a role, potentially resulting in its inhibition. | ||||||
Auranofin | 34031-32-8 | sc-202476 sc-202476A sc-202476B | 25 mg 100 mg 2 g | $153.00 $214.00 $4000.00 | 39 | |
Auranofin is a gold-containing compound used as an anti-rheumatic drug. It inhibits thioredoxin reductase, impacting redox homeostasis. The disruption of redox balance can indirectly influence cellular pathways involving CRIF1, as CRIF1 is associated with cellular responses to oxidative stress. | ||||||
2-Methoxyestradiol | 362-07-2 | sc-201371 sc-201371A | 10 mg 50 mg | $71.00 $288.00 | 6 | |
2-Methoxyestradiol is a natural metabolite of estrogen with anti-angiogenic and antiproliferative properties. It interferes with microtubule function, impacting cellular processes such as mitosis. The disruption of microtubules can indirectly influence pathways involving CRIF1, as CRIF1 is associated with the regulation of cell cycle progression. | ||||||
Niclosamide | 50-65-7 | sc-250564 sc-250564A sc-250564B sc-250564C sc-250564D sc-250564E | 100 mg 1 g 10 g 100 g 1 kg 5 kg | $38.00 $79.00 $188.00 $520.00 $1248.00 $5930.00 | 8 | |
Niclosamide is an anthelmintic drug that disrupts mitochondrial function. The impact on mitochondrial processes can indirectly influence cellular pathways involving CRIF1, as CRIF1 is associated with mitochondrial functions. The modulation of CRIF1 through mitochondrial dysfunction may lead to downstream effects on cellular processes where CRIF1 plays a role, potentially resulting in its inhibition. | ||||||
Salinomycin | 53003-10-4 | sc-253530 sc-253530C sc-253530A sc-253530B | 5 mg 10 mg 25 mg 100 mg | $162.00 $241.00 $406.00 $474.00 | 1 | |
Salinomycin is an ionophore antibiotic with anticancer properties. It disrupts mitochondrial function and influences cellular energetics. The impact on mitochondrial processes can indirectly influence pathways involving CRIF1, as CRIF1 is associated with mitochondrial functions. The modulation of CRIF1 through mitochondrial dysfunction may lead to downstream effects on cellular processes, potentially resulting in its inhibition. | ||||||
Lonidamine | 50264-69-2 | sc-203115 sc-203115A | 5 mg 25 mg | $105.00 $364.00 | 7 | |
Lonidamine is a hexokinase II inhibitor that disrupts glycolysis. By interfering with glycolytic processes, it indirectly influences cellular pathways where CRIF1 participates. The alteration in energy production and metabolism can lead to changes in CRIF1 function, contributing to its modulation or inhibition in cellular processes. | ||||||
AICAR | 2627-69-2 | sc-200659 sc-200659A sc-200659B | 50 mg 250 mg 1 g | $65.00 $280.00 $400.00 | 48 | |
AICAR is an AMP-activated protein kinase (AMPK) activator, influencing cellular energy metabolism. The activation of AMPK can indirectly impact CRIF1 function, as CRIF1 is involved in cellular responses to metabolic stress. The modulation of CRIF1 through AMPK activation may lead to downstream effects on cellular processes where CRIF1 plays a role, potentially resulting in its inhibition. | ||||||