Actinomycin D CAS: 50-76-0
MF: C62H86N12O16
MW: 1255.42
A potent antibiotic that binds to the GpC steps of DNA.

Actinomycin D (CAS 50-76-0)

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Synonym: Oncostatin K; Actinomycin IV
Application A potent antibiotic that binds to the GpC steps of DNA
CAS 등록번호: 50-76-0
순도: ≥98%
분자량: 1255.42
분자식: C62H86N12O16
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
* 참조분석증명서대량의 측정 데이터(함수량포함).
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Actinomycin D is a metabolite isolated from Streptomyces parvulus that binds to the GpC steps of DNA. The compound acts as an antibiotic and is more effective against gram-positive bacteria than gram negative bacteria. Actinomycin D can induce apoptosis in several cell lines such as lung and prostate cancer lines, and human blood lymphocytes, among others. This compound is also an RNA polymerase inhibitor. In studies it has been observed that Actinomycin D elevates p53 expression, leading to the increase of PUMAα/β (the p53 upregulated modulator of apoptosis protein; PUMA), and can also induce tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced caspase-dependent and -independent apoptosis.


References

1. Bailey, S.A., et al. 1993. Biochemistry. 32: 5881-5887. PMID: 8504108
2. Verhaegen, S., et al. 1995. Biochem. Pharmacol. 50: 1021-1029. PMID: 7575657
3. Kalousek, I., et al. 2007. Anticancer Drugs. 18: 763-772. PMID: 17581298
4. Wang, M.J., et al. 2007. Neurosci. Res. 59: 40-46. PMID: 17707539
5. Xu, H. and Krystal, G.W. 2010. Clin Cancer Res. PMID: 20732961

Physical State :
Solid
에서 유래된 :
Streptomyces parvulus
용해도 :
Soluble in DMSO (>20 mg/ml), 100% ethanol (1 mg/ml), methanol, chloroform, acetonitrile (9.80 - 10.20 mg/ml), and 1,2-Propanediol.
저장 :
Store at -20° C
녹는점 :
251-253° C
비등점 :
1386.05° C at 760 mmHg (Predicted)
밀도 :
1.43 g/cm3 (Predicted)
굴절률 :
n20D 1.66 (Predicted)
Optical Activity :
α28/D -315°, c = 0.25 in methanol
연구용으로만 사용가능합니다. 진단이나 치료용으로 사용불가합니다.
WGK Germany :
3
RTECS :
AU1575000
PubChem CID :
2019
Merck Index :
14: 2800
MDL Number :
MFCD00005033
EC Number :
200-063-6
Beilstein Registry :
605235
SMILES :
CC1C(C(=O)NC(C(=O)N2CCCC2C(=O)N(CC(=O)N(C(C(=O)O1)C(C)C)C)C)C(C)C)NC(=O)C3=C4C(=C(C=C3)C)OC5=C(C(=O)C(=C(C5=N4)C(=O)NC6C(OC(=O)C(N(C(=O)CN(C(=O)C7CCCN7C(=O)C(NC6=O)C(C)C)C)C)C(C)C)C)N)C

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Actinomycin D  논문정보

다른 사용자의 Actinomycin D사용법보기. 클릭하여 PubMed entry보기 .

Citations 1 to 10 of {3} total

PMID: # 31222373  Luo, Y. et al. 2019. Cell. Mol. Life Sci.

PMID: # 30870073  Song, H.|Feng, X.|Zhang, H.|Luo, Y.|Huang, J.|Lin, M.|Jin, J.|Ding, X.|Wu, S.|Huang, H.|Yu, T.|Zhang, M.|Hong, H.|Yao, S.|Zhao, Y.|Zhang, Z.| et al. 2019. Autophagy. 15: 1419-1437.

PMID: # 30796352  Yang, F.|Jin, H.|Que, B.|Chao, Y.|Zhang, H.|Ying, X.|Zhou, Z.|Yuan, Z.|Su, J.|Wu, B.|Zhang, W.|Qi, D.|Chen, D.|Min, W.|Lin, S.|Ji, W.| et al. 2019. Oncogene. 38: 4755-4772.

PMID: # 30639474  Liu, Y.|Wei, W.|Hong, C.|Wang, Y.|Sun, X.|Ma, J.|Zheng, F.| et al. 2019. Mol. Immunol. 107: 10-20.

PMID: # 30821592  Peng, M.|Wang, J.|Tian, Z.|Zhang, D.|Jin, H.|Liu, C.|Xu, J.|Li, J.|Hua, X.|Xu, J.|Huang, C.|Huang, C.| et al. 2019. Autophagy.

PMID: # 31119302  Liu, Y.|Wei, W.|Wang, Y.|Wan, C.|Bai, Y.|Sun, X.|Ma, J.|Zheng, F.| et al. 2019. Inflamm. Res. 68: 597-611.

PMID: # 30873168  Figliuolo da Paz, V.|Jamwal, DR.|Gurney, M.|Midura-Kiela, M.|Harrison, CA.|Cox, C.|Wilson, JM.|Ghishan, FK.|Kiela, PR.| et al. 2019. Front Immunol. 10: 304.

PMID: # 30602711  Weiss, J.| et al. 2018. Molecules. 24:

PMID: # 30414569  Shu, Y.|Wu, K.|Zeng, Z.|Huang, S.|Ji, X.|Yuan, C.|Zhang, L.|Liu, W.|Huang, B.|Feng, Y.|Zhang, B.|Dai, Z.|Shen, Y.|Luo, W.|Wang, X.|Liu, B.|Lei, Y.|Ye, Z.|Zhao, L.|Cao, D.|Yang, L.|Chen, X.|Luu, HH.|Reid, RR.|Wolf, JM.|Lee, MJ.|He, TC.| et al. 2018. Mol Ther Nucleic Acids. 13: 556-567.

PMID: # 29684377  Tocchetti, GN. et al. 2018. Biochem. Pharmacol. 154: 118-126.

Citations 1 to 10 of {3} total
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