Date published: 2026-5-25

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CRELD2 Inhibitors

CRELD2 inhibitors belong to a specialized class of chemical compounds designed to selectively impede the activity of the Cysteine-rich with EGF-like domains 2 (CRELD2) protein. The CRELD2 protein, encoded by the CRELD2 gene, is recognized for its involvement in diverse cellular processes, particularly in embryonic development and tissue homeostasis. This class of inhibitors is meticulously engineered to modulate the function of CRELD2 by interfering with its molecular interactions or biochemical pathways. Researchers focus on identifying small molecules or compounds with the capability to bind specifically to CRELD2, disrupting its normal cellular functions.

CRELD2 inhibitors are characterized by their precise arrangements of atoms and functional groups, allowing for targeted interactions with the CRELD2 protein. These inhibitors may act through various mechanisms, such as competitive binding to the active site of CRELD2 or altering the protein's conformation to inhibit its biological activity. The development of CRELD2 inhibitors involves a combination of computational modeling, medicinal chemistry, and biochemical assays to optimize their potency and selectivity.

SEE ALSO...

Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Tunicamycin

11089-65-9sc-3506A
sc-3506
5 mg
10 mg
$172.00
$305.00
66
(3)

Inhibits N-linked glycosylation, leading to ER stress which CRELD2 might be involved in regulating.

Thapsigargin

67526-95-8sc-24017
sc-24017A
1 mg
5 mg
$136.00
$446.00
114
(2)

A SERCA pump inhibitor that disrupts calcium homeostasis, inducing ER stress that CRELD2 is potentially involved.

Brefeldin A

20350-15-6sc-200861C
sc-200861
sc-200861A
sc-200861B
1 mg
5 mg
25 mg
100 mg
$31.00
$53.00
$124.00
$374.00
25
(3)

Disrupts ER-Golgi transport, influencing protein folding and possibly affecting CRELD2's functional context.

MG-132 [Z-Leu- Leu-Leu-CHO]

133407-82-6sc-201270
sc-201270A
sc-201270B
5 mg
25 mg
100 mg
$60.00
$265.00
$1000.00
163
(3)

A proteasome inhibitor that can lead to increased ER stress by accumulation of misfolded proteins.

Sodium phenylbutyrate

1716-12-7sc-200652
sc-200652A
sc-200652B
sc-200652C
sc-200652D
1 g
10 g
100 g
1 kg
10 kg
$77.00
$166.00
$622.00
$5004.00
$32783.00
43
(1)

A chemical chaperone that can reduce ER stress, potentially modulating CRELD2's activity.

Eeyarestatin I

412960-54-4sc-358130B
sc-358130
sc-358130A
sc-358130C
sc-358130D
sc-358130E
5 mg
10 mg
25 mg
50 mg
100 mg
500 mg
$114.00
$203.00
$354.00
$697.00
$1363.00
$5836.00
12
(1)

Inhibitor of ER-associated degradation, might affect CRELD2's role in protein quality control.

Chloroquine

54-05-7sc-507304
250 mg
$69.00
2
(0)

Lysosomotropic agent that can cause ER stress by preventing autophagy, indirectly affecting CRELD2.

Cyclosporin A

59865-13-3sc-3503
sc-3503-CW
sc-3503A
sc-3503B
sc-3503C
sc-3503D
100 mg
100 mg
500 mg
10 g
25 g
100 g
$63.00
$92.00
$250.00
$485.00
$1035.00
$2141.00
69
(5)

Immunosuppressant that inhibits calcineurin, affecting ER stress and possibly CRELD2's activity.

Salubrinal

405060-95-9sc-202332
sc-202332A
1 mg
5 mg
$34.00
$104.00
87
(2)

Selective inhibitor of eIF2α dephosphorylation, which is part of the ER stress response that may involve CRELD2.

Nelfinavir

159989-64-7sc-507314
10 mg
$168.00
(0)

An HIV protease inhibitor that has been shown to induce ER stress, potentially influencing CRELD2.