Sodium Phenylbutyrate: sc-200652. Western blot analysis of p21 expression in untreated (A) and Sodium Phenylbutyrate treated (B) Hep G2 whole cell lysates. Note upregulation of p21 expression in lane B. Antibody tested: p21 (SX118): sc-53870.
Sodium phenylbutyrate (CAS 1716-12-7)
See product citations (43)
Alternate Names:
Sodium phenylbutyrate is also known as Sodium 4-Phenylbutyrate.
Application:
Sodium phenylbutyrate is an HDAC inhibitor and caspase activator shown to rescue the trafficking of misfolded proteins.
CAS Number:
1716-12-7
Purity:
≥98%
Molecular Weight:
186.18
Molecular Formula:
C10H11O2•Na
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Sodium phenylbutyrate, an HDAC (histone deacetylase) inhibitor, causes cellular differentiation, growth arrest, and apoptosis in certain cells. It has been reported to cause cell growth arrest at the G1 phase and induce apoptosis through activation of JNK. Studies suggest that Sodium phenylbutyrate also acts as a chemical chaperone by causing a reduction of the load of mutant and mislocated proteins retained in the endoplasmic reticulum (ER). Other experiments have noted that it demonstrates neuroprotective capabilities by attenuating infarction volume, apoptosis, hemispheric swelling and improving neurological status in a murine model of hypoxia-ischemia. Moreover, Sodium phenylbutyrate may act to suppress ER-mediated apoptosis by initiating factor 2α phosphorylation, caspase-12 activation, and CCAAT/enhancer-binding protein homologous protein induction.
Sodium phenylbutyrate (CAS 1716-12-7) References
- Histone deacetylase inhibitor 4-phenylbutyrate suppresses GAPDH mRNA expression in glioma cells. | Appelskog, IB., et al. 2004. Int J Oncol. 24: 1419-25. PMID: 15138583
- Sodium 4-phenylbutyrate protects against cerebral ischemic injury. | Qi, X., et al. 2004. Mol Pharmacol. 66: 899-908. PMID: 15226415
- Sodium 4-phenylbutyrate induces apoptosis of human lung carcinoma cells through activating JNK pathway. | Zhang, X., et al. 2004. J Cell Biochem. 93: 819-29. PMID: 15389886
- Neuroprotective effects of phenylbutyrate in the N171-82Q transgenic mouse model of Huntington's disease. | Gardian, G., et al. 2005. J Biol Chem. 280: 556-63. PMID: 15494404
- Sodium 4-phenylbutyrate reduces myofiber damage in a mouse model of Duchenne muscular dystrophy. | Begam, M., et al. 2016. Appl Physiol Nutr Metab. 41: 1108-1111. PMID: 27628198
- Sodium phenylbutyrate abrogates African swine fever virus replication by disrupting the virus-induced hypoacetylation status of histone H3K9/K14. | Frouco, G., et al. 2017. Virus Res. 242: 24-29. PMID: 28916365
- Sodium Phenylbutyrate Inhibits Tumor Growth and the Epithelial-Mesenchymal Transition of Oral Squamous Cell Carcinoma In Vitro and In Vivo. | Qian, K., et al. 2018. Cancer Biother Radiopharm. 33: 139-145. PMID: 29658787
- The synergistic antifungal effects of sodium phenylbutyrate combined with azoles against Candida albicans via the regulation of the Ras-cAMP-PKA signalling pathway and virulence. | Sun, W., et al. 2019. Can J Microbiol. 65: 105-115. PMID: 30261147
- Sodium Phenylbutyrate Ameliorates Inflammatory Response Induced by Staphylococcus aureus Lipoteichoic Acid via Suppressing TLR2/NF-κB/NLRP3 Pathways in MAC-T Cells. | Wang, X., et al. 2018. Molecules. 23: PMID: 30469547
- Sodium 4-phenylbutyrate Attenuates High-fat Diet-induced Impaired Spermatogenesis. | Wang, EH., et al. 2018. Biomed Environ Sci. 31: 876-882. PMID: 30636657
- Sodium phenylbutyrate reduces repetitive self-grooming behavior and rescues social and cognitive deficits in mouse models of autism. | Ryu, YK., et al. 2021. Psychopharmacology (Berl). 238: 1833-1845. PMID: 33723660
- Sodium 4-Phenylbutyrate Reduces Ocular Hypertension by Degrading Extracellular Matrix Deposition via Activation of MMP9. | Maddineni, P., et al. 2021. Int J Mol Sci. 22: PMID: 34576258
- Sodium phenylbutyrate inhibits Schwann cell inflammation via HDAC and NFκB to promote axonal regeneration and remyelination. | Yadav, A., et al. 2021. J Neuroinflammation. 18: 238. PMID: 34656124
- Sodium Phenylbutyrate and Ursodoxicoltaurine: First Approval. | Heo, YA. 2022. CNS Drugs. 36: 1007-1013. PMID: 35907175
Inhibitor of:
βA2-crystallin, γC-crystallin, γE-crystallin, γF-crystallin, 3110043O21Rik, 5-Methylcytidine, ACOX1, ACSF3, Apoptosis, ASPG, BAG-6, BCKDE1A, BCKDK, BDH1, CD1D, CPS2, CREB3L1, CRELD2, D8S2298E, Derlin-2, EDEM3, Ero1-Lα, FAM134A_Fam134a, FAM158A, GPT2, H2-M10.3, HAO1, HDAC, Histone H10, HMGCL, HYPB, KIAA0406, Klkb1, LGALS9B, Lipocalin-10, MGC29506, MPC1L, ORNT1, ORP150, PCCA, PDH-E1β, PGDH, PHD, Ramp4, Ramp4-2, RECS1, RhBG, SP-C, SPCS2, Synoviolin, VAP-B/C, and XTP3-B.Activator of:
β-1,3-GalNAc-T2, β-defensin 108A, 3830417A13Rik, 5430405G05Rik, AADACL4, ABC-A1, ABCA, ABCB5, ABCB7, ABCF3, Abcg3, AHSP, ALG1, ALG6, alpha-L-iduronidase, Apg-2 (HSPA4), apoA, Aspartoacylase-3, ATF-6, Atlastin-3, ATP10A, ATP8B, ATP8B3, ATXN1L, BAP29, Bles03, BNIP-1, BTBD8, C1orf94, C3orf18, C3orf33, CALR4, caspase-12, CCDC48, CCT B, CELF3, CES7, CFTR, CLN6, CPPED1, CREB3L2, Cyp4f17, D8S2298E, DAD1, DC2_Ostc, DDRGK1, DEHAL1, DIMT1, DJ-1, DnaJB4, DnaJC1, DnaJC3, DPAGT1, DPRP, DPY19L3, EDEM2, EG626970, EHZF, ERGIC-53, ERp57, FAM119B, FAM126B, FAM62C, FAM69A, FKBP9, FLYWCH1, FNDC8, FucT-l, G6PD, Gemin4, GLT8D1, Gm766, GPT, GRP 78, GRP 94, H2-M9, Hbb-b2, Hemoglobin, Hemoglobin γ, Hep B preS1, Hep B sAg, HERPUD2, HEXA, Histone H2A.Z, IBRDC1, IDH1, IQCF1, ITI-H1, JNK, KDEL ER Marker, KDEL receptor, Keratin 40, Kex2, LAP1B, LIMP III, LL-37, LOC100039346, LOC730159, LYAG, MAGE-A1, MAN1B1, MAU-2, MCFD2, Morc4, n-Octylthioglucoside, NAPRT, NBPF3, NDRG3, NPAL3, ORP-2, OS-9, OSBP, OST4, OTTMUSG00000010747, OTTMUSG00000011097, OTTMUSG00000016607, OTTMUSG00000016611, PAI-RBP1, Pecanex 2, Peroxisome 26, POLR2J3, PPC Synthetase, PPIAL4, PRAMEF23, PRR19, RBM38, REEP4, Rer1, RFT1, RHBDL2, Ribophorin II, RNF170, Rtn-2, SBF2, Sec61, Sec61α1, Sec61β, Sel-1L, Sel-1L2, Set1, SGTB, SIL1, SLC35A2, SLC35B2, SMF_Hmgxb3, SPATA24, SRP54, SRP72, SUCLA2, TAG-72, TCP-1 α, TCP-1 ζ2, TMED3, TMED5, TMEM111, TMEM165, TMEM195, TMPRSS11E, TMX3, TRAP-δ, TSR3, TXNDC13, TXNDC15, Ufc1, UFD1, UGGT1, Vmn1r31, XBP-1, ZMYM3, ZNF222, ZNF295, ZNF498, and ZNF687.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Sodium phenylbutyrate, 1 g | sc-200652 | 1 g | $77.00 | |||
Sodium phenylbutyrate, 10 g | sc-200652A | 10 g | $166.00 | |||
Sodium phenylbutyrate, 100 g | sc-200652B | 100 g | $622.00 | |||
Sodium phenylbutyrate, 1 kg | sc-200652C | 1 kg | $5004.00 | |||
Sodium phenylbutyrate, 10 kg | sc-200652D | 10 kg | $32783.00 |