CPM Inhibitors
Chemical inhibitors of Carboxypeptidase M (CPM) operate through a variety of mechanisms, primarily focused on the chelation of metal ions which are crucial for the enzymatic activity of metalloproteases like CPM. Phosphoramidon, for instance, inhibits metalloproteases by binding to their active sites, which likely includes the active site of CPM, leading to a decrease in its proteolytic function. Similarly, Actinonin can directly inhibit CPM by chelating the metal ion at its active site, thereby blocking substrate access and inhibiting proteolytic activity. EDTA and 1,10-Phenanthroline further exploit the metal-dependency of CPM, sequestering the metal ions away from the enzyme's active site, which is essential for the hydrolysis of peptide bonds, thus rendering CPM inactive.
Marimastat and Batimastat, both broad-spectrum metalloprotease inhibitors, can bind to the active site of CPM, preventing substrate cleavage. Ilomastat, with a similar inhibitory profile, would engage with the zinc-binding site of CPM, obstructing the enzyme's interaction with its substrates. Doxycycline and Minocycline, despite their primary use as antibiotics, can also exhibit inhibitory effects on CPM by chelating the metal ion at the active site, a necessity for the protease's function. Chelerythrine and Bisindolylmaleimide I, inhibitors of protein kinase C, can indirectly inhibit CPM by modifying phosphorylation states within the cell, which can be essential for CPM's activity or stability.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Phosphoramidon | 119942-99-3 | sc-201283 sc-201283A | 5 mg 25 mg | $199.00 $632.00 | 8 | |
Phosphoramidon is a metalloprotease inhibitor that can inhibit the activity of neprilysin, which is another metalloprotease like CPM. By inhibiting neprilysin and potentially other metalloproteases, phosphoramidon may indirectly reduce the functional activity of the CPM protein by causing a compensatory reduction in protease activity within the cell, indirectly leading to the reduced function of CPM. | ||||||
Actinonin | 13434-13-4 | sc-201289 sc-201289B | 5 mg 10 mg | $170.00 $385.00 | 3 | |
Actinonin is a peptide deformylase inhibitor that also behaves as an inhibitor of metalloproteases. It could inhibit the metalloprotease activity of CPM by binding to the active site and chelating the metal ion that is necessary for enzyme activity, leading to the inhibition of CPM's proteolytic function. | ||||||
1,10-Phenanthroline | 66-71-7 | sc-255888 sc-255888A | 2.5 g 5 g | $23.00 $32.00 | ||
1,10-Phenanthroline acts as a metalloprotease inhibitor by chelating metal ions that are essential for the catalytic activity of metalloenzymes. By binding to the metal cofactor in the CPM active site, it would inhibit the proteolytic activity of CPM. | ||||||
Marimastat | 154039-60-8 | sc-202223 sc-202223A sc-202223B sc-202223C sc-202223E | 5 mg 10 mg 25 mg 50 mg 400 mg | $168.00 $218.00 $404.00 $629.00 $4900.00 | 19 | |
Marimastat is a broad-spectrum metalloprotease inhibitor. It could inhibit CPM by binding to its active site and preventing the interaction of the protein with its substrates, thereby inhibiting its proteolytic function. | ||||||
Batimastat | 130370-60-4 | sc-203833 sc-203833A | 1 mg 10 mg | $179.00 $377.00 | 24 | |
Batimastat is another broad-spectrum inhibitor of metalloproteases. It could inhibit CPM in a manner similar to marimastat, by binding to the active site of CPM, thus preventing substrate cleavage. | ||||||
GM 6001 | 142880-36-2 | sc-203979 sc-203979A | 1 mg 5 mg | $77.00 $270.00 | 55 | |
Ilomastat, also known as GM6001, is a matrix metalloprotease inhibitor that could inhibit CPM by binding to the zinc-binding site of the metalloprotease domain, which would interfere with the enzyme's ability to interact with its substrates and inhibit its function. | ||||||
Doxycycline Hyclate | 24390-14-5 | sc-204734B sc-204734 sc-204734A sc-204734C | 100 mg 1 g 5 g 25 g | $27.00 $50.00 $105.00 $194.00 | 25 | |
Doxycycline, while known primarily as an antibiotic, has been shown to inhibit metalloproteases. Its inhibitory effect on CPM could stem from its ability to chelate metal ions at the active site of metalloproteases, thereby inhibiting their activity. | ||||||
Minocycline, Hydrochloride | 13614-98-7 | sc-203339 sc-203339A sc-203339B sc-203339C sc-203339D sc-203339E sc-203339F | 50 mg 250 mg 1 g 2.5 g 10 g 100 g 1 kg | $52.00 $171.00 $281.00 $634.00 $1259.00 $5836.00 $24980.00 | 36 | |
Minocycline is an antibiotic with metalloprotease inhibitory properties. It inhibits metalloproteases possibly by chelating the metal ion in the active site, which would inhibit the activity of CPM by preventing the metal-dependent proteolysis of substrates. | ||||||
Chelerythrine chloride | 3895-92-9 | sc-3547 sc-3547A | 5 mg 25 mg | $90.00 $317.00 | 17 | |
Chelerythrine is known to inhibit protein kinase C (PKC). By inhibiting PKC, chelerythrine may reduce the phosphorylation of proteins which could be required for the proper functioning or localization of CPM, thereby indirectly inhibiting CPM activity. | ||||||
Bisindolylmaleimide I (GF 109203X) | 133052-90-1 | sc-24003A sc-24003 | 1 mg 5 mg | $105.00 $242.00 | 36 | |
Bisindolylmaleimide I is a specific inhibitor of protein kinase C. It can indirectly inhibit CPM by altering phosphorylation patterns within the cell that could affect CPM activity or stability, without directly binding to CPM itself. | ||||||