COX4 Activators
Common COX4 Activators include, but are not limited to Resveratrol CAS 501-36-0, AICAR CAS 2627-69-2, Retinoic Acid, all trans CAS 302-79-4, Bezafibrate CAS 41859-67-0 and NAD+, Free Acid CAS 53-84-9.
COX4 activators belong to a class of compounds that interact with Cytochrome c Oxidase Subunit 4 (COX4), a crucial component of the electron transport chain (ETC) in mitochondria. The electron transport chain is a series of protein complexes and cytochromes located in the inner mitochondrial membrane, which plays a central role in oxidative phosphorylation, the primary process by which cells generate adenosine triphosphate (ATP), the cellular energy currency. COX4 is a subunit of cytochrome c oxidase (Complex IV), the terminal enzyme in the electron transport chain, which transfers electrons from cytochrome c to molecular oxygen, ultimately producing water and contributing to the generation of a proton gradient used to synthesize ATP.
COX4 activators are compounds designed to modulate the activity of COX4, with applications in understanding mitochondrial function, cellular bioenergetics, and metabolic pathways. By affecting COX4, these compounds can have a profound impact on cellular energy production and metabolism. The ability to activate or inhibit COX4 may provide insights into the regulation of oxidative phosphorylation, offering researchers valuable tools to investigate mitochondrial function in health and disease.
Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
A polyphenolic compound found in grapes and wine. Resveratrol has been shown to enhance mitochondrial function, potentially influencing COX4 expression as part of a broader effect on mitochondrial biogenesis. | ||||||
Metformin | 657-24-9 | sc-507370 | 10 mg | $79.00 | 2 | |
Primarily an anti-diabetic suggested compound, metformin activates AMPK, which can lead to increased mitochondrial biogenesis and potentially upregulation of COX4. | ||||||
AICAR | 2627-69-2 | sc-200659 sc-200659A sc-200659B | 50 mg 250 mg 1 g | $65.00 $280.00 $400.00 | 48 | |
An AMPK activator. By activating AMPK, AICAR can promote mitochondrial biogenesis, which might lead to increased COX4 expression. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic acid can influence mitochondrial function and might indirectly modulate COX4 expression during differentiation processes. | ||||||
Bezafibrate | 41859-67-0 | sc-204650B sc-204650 sc-204650A sc-204650C | 500 mg 1 g 5 g 10 g | $31.00 $46.00 $122.00 $204.00 | 5 | |
A PPAR pan-agonist. It might enhance mitochondrial biogenesis and oxidative metabolism, leading to potential changes in COX4 expression. | ||||||
NAD+, Free Acid | 53-84-9 | sc-208084B sc-208084 sc-208084A sc-208084C sc-208084D sc-208084E sc-208084F | 1 g 5 g 10 g 25 g 100 g 1 kg 5 kg | $57.00 $191.00 $302.00 $450.00 $1800.00 $3570.00 $10710.00 | 4 | |
A crucial cofactor in cellular redox reactions. Elevating NAD+ levels can boost mitochondrial function, potentially influencing COX4 expression. | ||||||
SRT1720 | 1001645-58-4 | sc-364624 sc-364624A | 5 mg 10 mg | $197.00 $364.00 | 13 | |
Sirtuins, especially SIRT1, influence mitochondrial function. Activating sirtuins might indirectly upregulate COX4. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
A major polyphenol in green tea. EGCG has been shown to influence mitochondrial function and might affect COX4 expression. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
An mTOR inhibitor. By inhibiting mTOR, rapamycin might influence cellular energy balance and mitochondrial function, potentially affecting COX4 expression. | ||||||
Oligomycin | 1404-19-9 | sc-203342 sc-203342C | 10 mg 1 g | $149.00 $12495.00 | 18 | |
An inhibitor of ATP synthase. By inhibiting ATP synthesis, it might create a feedback mechanism leading to changes in COX4 expression as cells attempt to regulate energy production. | ||||||