COX14 Inhibitors
COX14 inhibitors are chemical compounds that specifically target and inhibit the activity of the COX14 protein, which is involved in the assembly and function of the mitochondrial respiratory chain. COX14 is a key assembly factor for the cytochrome c oxidase complex (Complex IV), which plays a crucial role in the electron transport chain within mitochondria. This complex is responsible for the final step in cellular respiration, where electrons are transferred from cytochrome c to oxygen, facilitating the production of ATP through oxidative phosphorylation. COX14 is essential for the proper assembly of this multi-subunit enzyme complex, ensuring the correct integration of various protein components within the inner mitochondrial membrane. Without COX14, the assembly of Complex IV is incomplete, leading to impaired mitochondrial function and reduced ATP production.
Inhibitors of COX14 act by interfering with the protein's role in the assembly of the cytochrome c oxidase complex, thereby disrupting mitochondrial respiration and energy production. These inhibitors may target specific regions of the COX14 protein that are critical for its function in coordinating the assembly of the Complex IV subunits. By blocking COX14's activity, these compounds provide valuable tools for studying the molecular mechanisms underlying mitochondrial biogenesis and the assembly of respiratory chain components. Researchers use COX14 inhibitors to explore the impact of disrupted Complex IV assembly on cellular metabolism and mitochondrial dynamics, gaining insights into the regulatory pathways that govern energy production in cells. Understanding COX14's function through inhibition helps in dissecting the intricate processes involved in mitochondrial function and its broader role in cellular energy homeostasis.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Antimycin A | 1397-94-0 | sc-202467 sc-202467A sc-202467B sc-202467C | 5 mg 10 mg 1 g 3 g | $55.00 $63.00 $1675.00 $4692.00 | 51 | |
Antimycin A inhibits the mitochondrial electron transport chain at complex III, which is necessary for the proper functioning of COX14 in the assembly of cytochrome c oxidase. Inhibition of this chain can impede the maturation of COX1, which requires COX14 for its assembly. | ||||||
Sodium azide | 26628-22-8 | sc-208393 sc-208393B sc-208393C sc-208393D sc-208393A | 25 g 250 g 1 kg 2.5 kg 100 g | $43.00 $155.00 $393.00 $862.00 $90.00 | 8 | |
Sodium azide specifically inhibits complex IV of the mitochondrial electron transport chain, which is the final destination of electrons from cytochrome c oxidase. By inhibiting this complex, electrons cannot be transferred effectively, indirectly inhibiting COX14's role in the assembly of the oxidase complex. | ||||||
Oligomycin | 1404-19-9 | sc-203342 sc-203342C | 10 mg 1 g | $149.00 $12495.00 | 18 | |
Oligomycin inhibits ATP synthase in mitochondria, leading to an increased proton gradient. This can indirectly affect the electron transport chain and, consequently, reduce the need for functional cytochrome c oxidase complex assembly, in which COX14 is involved. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $48.00 | ||
Zinc has been shown to inhibit copper chaperones which are involved in the delivery of copper to the cytochrome c oxidase complex. As COX14 is involved in this complex's assembly, inhibiting copper delivery can indirectly inhibit the function of COX14. | ||||||
2-Thenoyltrifluoroacetone | 326-91-0 | sc-251801 | 5 g | $37.00 | 1 | |
Thenoyltrifluoroacetone (TTFA) is an inhibitor of complex II of the mitochondrial electron transport chain. By inhibiting complex II, the overall electron flow through the chain is disrupted, which can reduce the functional demand for COX14 in the assembly of the cytochrome c oxidase complex. | ||||||
Rotenone | 83-79-4 | sc-203242 sc-203242A | 1 g 5 g | $89.00 $259.00 | 41 | |
Rotenone is an inhibitor of complex I in the mitochondrial electron transport chain, which can lead to a buildup of NADH and a reduced flow of electrons through the chain, indirectly reducing the requirement for COX14's involvement in cytochrome c oxidase assembly. | ||||||
Atovaquone | 95233-18-4 | sc-217675 | 10 mg | $270.00 | 2 | |
Atovaquone selectively inhibits the cytochrome b component of complex III in the electron transport chain. This selective inhibition indirectly lessens the functional need for COX14 in the assembly of the cytochrome c oxidase complex. | ||||||