COX11 Activators
COX11 activators belong to a distinct chemical class known for their ability to modulate the activity of the COX11 protein, a crucial component in cellular respiration and mitochondrial function. The COX11 gene encodes a copper chaperone that plays a pivotal role in the assembly of cytochrome c oxidase (CcO), the terminal enzyme complex in the electron transport chain responsible for transferring electrons to oxygen during cellular respiration. Activation of COX11 is essential for the proper functioning of CcO, ensuring efficient electron transfer and preventing the accumulation of reactive oxygen species (ROS) within the mitochondria.
Structurally, COX11 activators typically feature chemical moieties that facilitate the interaction with specific binding sites on the COX11 protein, thereby enhancing its affinity for copper ions. Copper is a vital cofactor for CcO, and the COX11 protein acts as a mediator in delivering copper to the catalytic subunits of CcO. The activation of COX11 by these compounds contributes to the maintenance of mitochondrial homeostasis and cellular energy production. The intricate interplay between COX11 activators and the COX11 protein underscores their significance in regulating mitochondrial function and cellular redox balance, making them potential candidates for further exploration in the realm of cellular bioenergetics and mitochondrial physiology. Further research into the mechanisms underlying COX11 activation may unravel new insights into cellular respiration and provide avenues for developing compounds that target mitochondrial function for various scientific and biomedical purposes.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Aspirin | 50-78-2 | sc-202471 sc-202471A | 5 g 50 g | $20.00 $41.00 | 4 | |
Aspirin is known to inhibit cyclooxygenases (COX-1 and COX-2). Even though inhibition might appear counterproductive, the subsequent decrease in prostaglandin synthesis can potentially enhance the function of COX11, as it is involved in the same metabolic pathway. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol is a polyphenolic compound that can activate SIRT1, which is known to regulate oxidative stress. The activation of SIRT1 can indirectly enhance the expression and function of COX11, which is a copper chaperone involved in the delivery of copper to cytochrome c oxidase. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin has antioxidant properties and can regulate oxidative stress in cells. Since COX11 is involved in the mitochondrial respiratory chain and contributes to managing oxidative stress, curcumin can indirectly enhance the function of COX11. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $108.00 $245.00 $918.00 $49.00 | 33 | |
Quercetin is a flavonoid known to act as an antioxidant. By reducing oxidative stress, it enhances the overall function of COX11 in the mitochondrial respiratory chain. | ||||||
Berberine | 2086-83-1 | sc-507337 | 250 mg | $90.00 | 1 | |
Berberine can activate AMPK, a key regulator of cellular energy homeostasis. By increasing the cellular ATP levels, it indirectly influences the function of COX11 in the electron transport chain. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
Epigallocatechin gallate (EGCG) is a catechin known to mitigate oxidative stress. This can indirectly enhance the function of COX11, which is involved in the mitochondrial respiratory chain. | ||||||
α-Lipoic Acid | 1077-28-7 | sc-202032 sc-202032A sc-202032B sc-202032C sc-202032D | 5 g 10 g 250 g 500 g 1 kg | $68.00 $120.00 $208.00 $373.00 $702.00 | 3 | |
Alpha-lipoic acid is an antioxidant compound. Its ability to reduce oxidative stress can indirectly enhance the functionality of COX11 in the mitochondrial respiratory chain. | ||||||
N-Acetyl-L-cysteine | 616-91-1 | sc-202232 sc-202232A sc-202232C sc-202232B | 5 g 25 g 1 kg 100 g | $33.00 $73.00 $265.00 $112.00 | 34 | |
N-acetylcysteine is a precursor of glutathione, which is a potent antioxidant. It can reduce oxidative stress, indirectly enhancing the function of COX11. | ||||||
(+)-α-Tocopherol | 59-02-9 | sc-214454 sc-214454A sc-214454B | 10 g 25 g 100 g | $42.00 $61.00 $138.00 | ||
Vitamin E is a fat-soluble antioxidant, which can help manage oxidative stress and indirectly enhance the functionality of COX11 in the electron transport chain. | ||||||
Coenzyme Q10 | 303-98-0 | sc-205262 sc-205262A | 1 g 5 g | $70.00 $180.00 | 1 | |
Coenzyme Q10 is a component of the electron transport chain and can enhance the function of COX11 by improving the overall efficiency of the electron transport chain. | ||||||