Date published: 2025-9-29

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Cox-2 Inhibitors

COX-2 inhibitors, short for Cyclooxygenase-2 inhibitors, constitute a significant class of compounds known for their specific interaction with the cyclooxygenase-2 enzyme. Cyclooxygenases are enzymes responsible for the synthesis of prostaglandins, which play pivotal roles in various physiological processes. COX-2, in particular, is an isoform of cyclooxygenase that is induced in response to inflammation and cellular stress. It is crucial for the production of prostaglandins involved in mediating pain, fever, and inflammation. COX-2 inhibitors, as the name suggests, are compounds designed to selectively target and inhibit the activity of the COX-2 enzyme, thereby modulating the synthesis of prostaglandins associated with the inflammatory response.These inhibitors typically possess a chemical structure that allows them to bind specifically to the active site of the COX-2 enzyme, disrupting its catalytic function. This selectivity is a key feature, as it distinguishes them from non-selective NSAIDs (Nonsteroidal Anti-Inflammatory Drugs) that inhibit both COX-1 and COX-2 enzymes. COX-2 inhibitors are characterized by their ability to reduce inflammation and pain without affecting the protective functions of COX-1, such as maintaining the integrity of the gastric mucosa and regulating platelet aggregation. This selectivity is a critical factor in minimizing adverse effects like gastric ulcers and bleeding tendencies associated with non-selective NSAIDs.

Items 31 to 40 of 107 total

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Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

4′-Hydroxy Diclofenac

64118-84-9sc-202423
sc-202423A
1 mg
5 mg
$170.00
$612.00
6
(0)

4'-Hydroxy Diclofenac exhibits selective inhibition of COX-2 through its unique structural conformation, which facilitates specific interactions with the enzyme's active site. This compound's ability to form stable complexes with COX-2 enhances its inhibitory potency. Its distinct electron-donating groups influence reaction kinetics, promoting a favorable binding affinity. Furthermore, the compound's hydrophobic characteristics contribute to its distribution within lipid environments, impacting its overall bioavailability.

Celecoxib Carboxylic Acid

170571-01-4sc-207408
10 mg
$389.00
(0)

Celecoxib Carboxylic Acid acts as a selective COX-2 inhibitor, characterized by its unique carboxylic acid functional group that enhances hydrogen bonding with the enzyme's active site. This interaction stabilizes the enzyme-substrate complex, leading to a reduction in catalytic activity. The compound's polar nature influences solubility and distribution in biological systems, while its specific steric configuration allows for precise molecular recognition, optimizing its inhibitory effects.

Inotilone

906366-79-8sc-207758
5 mg
$164.00
(0)

Inotilone functions as a selective COX-2 inhibitor, distinguished by its unique structural features that facilitate specific interactions with the enzyme's active site. Its distinct molecular conformation promotes effective binding, altering the enzyme's conformational dynamics and inhibiting its activity. The compound's hydrophobic regions enhance membrane permeability, while its electronic properties influence reactivity and interaction kinetics, contributing to its selective inhibition profile.

Isoxicam

34552-84-6sc-235433
1 g
$97.00
(0)

Isoxicam exhibits selective inhibition of COX-2 through its unique binding affinity, characterized by specific hydrogen bonding and hydrophobic interactions within the enzyme's active site. The compound's rigid molecular framework allows for precise orientation, enhancing its interaction kinetics. Additionally, its polar functional groups contribute to solubility and reactivity, facilitating targeted modulation of inflammatory pathways while minimizing effects on COX-1. This selectivity is crucial for its biochemical behavior.

Meloxicam sodium salt

71125-39-8sc-215294
100 mg
$219.00
1
(0)

Meloxicam sodium salt demonstrates a distinctive mechanism of action as a selective COX-2 inhibitor, primarily through its ability to form stable complexes with the enzyme. The presence of specific functional groups enhances its solubility and promotes effective molecular interactions, allowing for a tailored fit within the COX-2 active site. This selectivity is further supported by its unique steric configuration, which minimizes interference with COX-1, thereby optimizing its biochemical specificity.

Acetylsalicylic Acid-d4

97781-16-3sc-217570
5 mg
$372.00
3
(1)

Acetylsalicylic Acid-d4 exhibits unique characteristics as a COX-2 inhibitor, primarily through its isotopic labeling, which alters reaction kinetics and enhances tracking in metabolic studies. Its deuterated structure influences hydrogen bonding and molecular dynamics, leading to distinct interactions with the enzyme's active site. This modification can affect the stability of enzyme-substrate complexes, providing insights into the enzyme's conformational changes during catalysis.

Sodium Salicylate

54-21-7sc-3520
sc-3520A
sc-3520B
sc-3520C
1 g
25 g
500 g
1 kg
$10.00
$25.00
$80.00
$136.00
8
(1)

Sodium Salicylate functions as a COX-2 inhibitor by engaging in specific hydrogen bonding interactions that stabilize its binding to the enzyme's active site. Its unique ionic nature enhances solubility and facilitates rapid diffusion across biological membranes. The compound's ability to modulate the enzyme's conformational dynamics is influenced by its carboxylate group, which can alter the electrostatic environment, impacting the overall reaction kinetics and selectivity in enzymatic pathways.

Rutaecarpine

84-26-4sc-205846
sc-205846A
10 mg
25 mg
$123.00
$359.00
1
(0)

Rutaecarpine acts as a COX-2 inhibitor through its distinctive molecular structure, which allows for effective steric hindrance at the enzyme's active site. This compound exhibits unique hydrophobic interactions that promote a stable binding conformation, influencing the enzyme's catalytic efficiency. Additionally, its specific functional groups can modulate the enzyme's allosteric sites, potentially altering substrate affinity and reaction rates, thereby impacting the overall metabolic pathways involved.

Deguelin

522-17-8sc-200657
sc-200657A
sc-200657B
5 mg
25 mg
500 mg
$81.00
$273.00
$1857.00
4
(1)

Deguelin functions as a COX-2 inhibitor by engaging in specific hydrogen bonding interactions with the enzyme's active site, which disrupts its catalytic activity. Its unique structural features facilitate selective binding, enhancing its inhibitory potency. Furthermore, Deguelin's lipophilic characteristics contribute to its ability to penetrate cellular membranes, influencing intracellular signaling pathways and modulating inflammatory responses through altered enzyme kinetics.

Pterostilbene, Pterocarpus marsupium

537-42-8sc-203223
sc-203223A
10 mg
100 mg
$207.00
$1173.00
(0)

Pterostilbene, derived from Pterocarpus marsupium, exhibits COX-2 inhibitory activity through its unique ability to form π-π stacking interactions with the enzyme's active site. This interaction stabilizes the enzyme-substrate complex, effectively reducing its catalytic efficiency. Additionally, Pterostilbene's hydrophobic nature enhances its membrane permeability, allowing it to influence lipid-mediated signaling pathways and alter cellular responses to inflammation.