Molecular structure of Inotilone, CAS Number: 906366-79-8
Inotilone (CAS 906366-79-8)
Alternate Names:
(2E)-2-[(3,4-Dihydroxyphenyl)methylene]-5-methyl-3(2H)-furanone
Application:
Inotilone is a potent Cox-2 inhibitor
CAS Number:
906366-79-8
Molecular Weight:
218.21
Molecular Formula:
C12H10O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Description
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SDS & Certificate of Analysis
A potent COX-2 inhibitor.
Inotilone (CAS 906366-79-8) References
- Pharmacologic approaches to the treatment of amyotrophic lateral sclerosis. | McGeer, EG. and McGeer, PL. 2005. BioDrugs. 19: 31-7. PMID: 15691215
- Targeting cyclooxygenase-2 for prevention and therapy of colorectal cancer. | Sinicrope, FA. 2006. Mol Carcinog. 45: 447-54. PMID: 16688727
- Inotilone and related phenylpropanoid polyketides from Inonotus sp. and their identification as potent COX and XO inhibitors. | Wangun, HV., et al. 2006. Org Biomol Chem. 4: 2545-8. PMID: 16791316
- Prevention of breast cancer: current state of the science and future opportunities. | Uray, IP. and Brown, PH. 2006. Expert Opin Investig Drugs. 15: 1583-600. PMID: 17107283
- Differential inhibitory effects of inotilone on inflammatory mediators, inducible nitric oxide synthase and cyclooxygenase-2, in LPS-stimulated murine macrophage. | Kuo, YC., et al. 2009. Mol Nutr Food Res. 53: 1386-95. PMID: 19743406
- α-Glucosidase and aldose reductase inhibitory activities from the fruiting body of Phellinus merrillii. | Huang, GJ., et al. 2011. J Agric Food Chem. 59: 5702-6. PMID: 21452825
- Inotilone suppresses phorbol ester-induced inflammation and tumor promotion in mouse skin. | Kuo, YC., et al. 2012. Mol Nutr Food Res. 56: 1324-32. PMID: 22641311
- Neuraminidase Inhibitors from the Fermentation Broth of Phellinus linteus. | Hwang, BS., et al. 2014. Mycobiology. 42: 189-92. PMID: 25071390
- DNA primase polypeptide 1 (PRIM1) involves in estrogen-induced breast cancer formation through activation of the G2/M cell cycle checkpoint. | Lee, WH., et al. 2019. Int J Cancer. 144: 615-630. PMID: 30097999
- Inotilone from Inonotus linteus suppresses lung cancer metastasis in vitro and in vivo through ROS-mediated PI3K/AKT/MAPK signaling pathways. | Chao, W., et al. 2019. Sci Rep. 9: 2344. PMID: 30787353
Inhibitor of:
Cox-2.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Inotilone, 5 mg | sc-207758 | 5 mg | $164.00 |