Date published: 2025-9-29

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Cox-2 Inhibitors

COX-2 inhibitors, short for Cyclooxygenase-2 inhibitors, constitute a significant class of compounds known for their specific interaction with the cyclooxygenase-2 enzyme. Cyclooxygenases are enzymes responsible for the synthesis of prostaglandins, which play pivotal roles in various physiological processes. COX-2, in particular, is an isoform of cyclooxygenase that is induced in response to inflammation and cellular stress. It is crucial for the production of prostaglandins involved in mediating pain, fever, and inflammation. COX-2 inhibitors, as the name suggests, are compounds designed to selectively target and inhibit the activity of the COX-2 enzyme, thereby modulating the synthesis of prostaglandins associated with the inflammatory response.These inhibitors typically possess a chemical structure that allows them to bind specifically to the active site of the COX-2 enzyme, disrupting its catalytic function. This selectivity is a key feature, as it distinguishes them from non-selective NSAIDs (Nonsteroidal Anti-Inflammatory Drugs) that inhibit both COX-1 and COX-2 enzymes. COX-2 inhibitors are characterized by their ability to reduce inflammation and pain without affecting the protective functions of COX-1, such as maintaining the integrity of the gastric mucosa and regulating platelet aggregation. This selectivity is a critical factor in minimizing adverse effects like gastric ulcers and bleeding tendencies associated with non-selective NSAIDs.

Items 21 to 30 of 107 total

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Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Niflumic acid

4394-00-7sc-204820
5 g
$31.00
3
(1)

Niflumic acid exhibits a selective inhibition of COX-2 through its unique ability to form hydrogen bonds with key amino acid residues in the enzyme's active site. This interaction alters the enzyme's conformation, reducing its catalytic efficiency. The compound's lipophilic nature enhances membrane permeability, facilitating its access to target sites. Additionally, its distinct electronic properties influence reaction kinetics, allowing for a nuanced modulation of inflammatory mediators.

9-cis-Retinoic acid

5300-03-8sc-205589
sc-205589B
sc-205589C
sc-205589D
sc-205589A
1 mg
25 mg
250 mg
500 mg
5 mg
$70.00
$416.00
$3060.00
$5610.00
$145.00
10
(1)

9-cis-Retinoic acid acts as a selective modulator of COX-2 by engaging in specific hydrophobic interactions with the enzyme's active site, promoting a conformational shift that diminishes its enzymatic activity. Its unique stereochemistry allows for enhanced binding affinity, while its ability to participate in π-π stacking interactions with aromatic residues further stabilizes the enzyme-inhibitor complex. This compound's dynamic behavior in lipid environments also influences its interaction kinetics, providing a sophisticated mechanism for regulating inflammatory pathways.

(S)-Ibuprofen

51146-56-6sc-200612
sc-200612A
1 g
5 g
$47.00
$140.00
4
(1)

(S)-Ibuprofen selectively inhibits COX-2 through its unique chiral structure, which facilitates precise interactions with the enzyme's active site. The compound's hydrophobic regions enhance binding affinity, while its ability to form hydrogen bonds with key amino acid residues contributes to a stable enzyme-inhibitor complex. Additionally, (S)-Ibuprofen's conformational flexibility allows it to adapt within the active site, influencing reaction kinetics and modulating inflammatory responses effectively.

Sulindac sulfide

32004-67-4sc-200118
sc-200118A
5 mg
25 mg
$73.00
$226.00
2
(1)

Sulindac sulfide exhibits selective inhibition of COX-2 by engaging in specific hydrophobic interactions with the enzyme's active site. Its unique structural features allow for the formation of stable π-π stacking interactions with aromatic residues, enhancing binding affinity. The compound's electron-withdrawing groups facilitate charge distribution, influencing reaction kinetics and promoting a favorable conformational arrangement that stabilizes the enzyme-inhibitor complex.

Leflunomide

75706-12-6sc-202209
sc-202209A
10 mg
50 mg
$20.00
$81.00
5
(1)

Leflunomide acts as a selective COX-2 inhibitor through its unique ability to form hydrogen bonds with key amino acid residues in the enzyme's active site. Its distinct molecular structure allows for effective steric hindrance, which disrupts the enzyme's catalytic activity. Additionally, Leflunomide's hydrophilic regions enhance solubility, promoting efficient interaction dynamics, while its conformational flexibility aids in optimizing binding affinity and specificity.

Deracoxib

169590-41-4sc-482703
25 mg
$150.00
(0)

Deracoxib is another COX-2 inhibitor used in veterinary medicine. It reduces inflammation and pain by selectively inhibiting COX-2 and reducing prostaglandins.

Tenidap

120210-48-2sc-204334
sc-204334A
10 mg
50 mg
$160.00
$580.00
1
(1)

Tenidap functions as a selective COX-2 inhibitor by engaging in specific hydrophobic interactions with the enzyme's active site, which stabilizes its binding. Its unique structural features facilitate the formation of π-π stacking interactions with aromatic residues, enhancing selectivity. The compound's kinetic profile reveals a rapid association and slower dissociation, indicating a strong affinity for COX-2. Furthermore, its conformational adaptability allows for optimal alignment within the enzyme's binding pocket.

(S)-(+)-Flurbiprofen

51543-39-6sc-205503
sc-205503A
sc-205503B
sc-205503C
10 mg
50 mg
1 g
1.5 g
$32.00
$140.00
$1025.00
$1841.00
1
(0)

(S)-(+)-Flurbiprofen acts as a selective COX-2 inhibitor through its unique stereochemistry, which enhances its interaction with the enzyme's active site. The compound exhibits a distinctive ability to form hydrogen bonds with key amino acid residues, promoting a stable enzyme-inhibitor complex. Its kinetic behavior is characterized by a moderate rate of association and a prolonged residence time, suggesting effective inhibition. Additionally, the compound's lipophilicity aids in its preferential binding to the COX-2 isoform over COX-1.

Meclofenamate sodium

6385-02-0sc-200532
sc-200532A
1 g
5 g
$51.00
$77.00
2
(0)

Meclofenamate sodium functions as a selective COX-2 inhibitor, distinguished by its unique structural conformation that facilitates specific interactions with the enzyme's active site. This compound exhibits a notable propensity for π-π stacking interactions with aromatic residues, enhancing binding affinity. Its reaction kinetics reveal a rapid onset of inhibition, coupled with a reversible binding mechanism, allowing for dynamic modulation of COX-2 activity. The compound's hydrophilic nature contributes to its solubility, influencing its distribution in biological systems.

Sulindac

38194-50-2sc-202823
sc-202823A
sc-202823B
1 g
5 g
10 g
$31.00
$84.00
$147.00
3
(1)

Sulindac acts as a selective COX-2 inhibitor, characterized by its unique dual-ring structure that allows for specific hydrogen bonding with the enzyme's active site. This compound demonstrates a distinct ability to stabilize transition states during enzymatic reactions, influencing its inhibition kinetics. Its lipophilic properties enhance membrane permeability, facilitating effective interaction with cellular targets. Additionally, Sulindac's metabolic pathways involve conversion to active sulfide forms, further modulating its biological effects.