Sulindac sulfide (CAS 32004-67-4)
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Sulindac sulfide is the active metabolite sulindac, and it is widely employed in research studies to understand its anti-inflammatory mechanism of action. Its inhibitory effect on cyclooxygenase (COX) enzymes, primarily COX-2, is of particular interest in the investigation of inflammatory pathways. Researchers use sulindac sulfide to probe the molecular basis of inflammation and to explore its impact on prostaglandin synthesis, which is vital for the regulation of inflammation. Sulindac sulfide is also of interest in cancer research due to its ability to induce apoptosis in certain types of cancer cells, providing insights into potential mechanisms for inhibiting tumor growth. Its role in modulating cellular processes through COX inhibition and other pathways makes sulindac sulfide useful for elucidating the complex biology of inflammation and tumorigenesis.
Sulindac sulfide (CAS 32004-67-4) References
- Sulindac derivatives inhibit growth and induce apoptosis in human prostate cancer cell lines. | Lim, JT., et al. 1999. Biochem Pharmacol. 58: 1097-107. PMID: 10484067
- Par-4, a proapoptotic gene, is regulated by NSAIDs in human colon carcinoma cells. | Zhang, Z. and DuBois, RN. 2000. Gastroenterology. 118: 1012-7. PMID: 10833474
- Sulindac sulfide, but not sulindac sulfone, inhibits colorectal cancer growth. | Williams, CS., et al. 1999. Neoplasia. 1: 170-6. PMID: 10933052
- Sulindac sulfide is a noncompetitive gamma-secretase inhibitor that preferentially reduces Abeta 42 generation. | Takahashi, Y., et al. 2003. J Biol Chem. 278: 18664-70. PMID: 12637581
- Combination of tumor necrosis factor-alpha with sulindac in human carcinoma cells in vivo. | Yasui, H., et al. 2003. Ann N Y Acad Sci. 1010: 273-7. PMID: 15033733
- The same gamma-secretase accounts for the multiple intramembrane cleavages of APP. | Zhao, G., et al. 2007. J Neurochem. 100: 1234-46. PMID: 17241131
- The integrated stress response-associated signals modulates intestinal tumor cell growth by NSAID-activated gene 1 (NAG-1/MIC-1/PTGF-beta). | Yang, H., et al. 2010. Carcinogenesis. 31: 703-11. PMID: 20130018
- A novel sulindac derivative lacking cyclooxygenase-inhibitory activities suppresses carcinogenesis in the transgenic adenocarcinoma of mouse prostate model. | Zhang, Y., et al. 2010. Cancer Prev Res (Phila). 3: 885-95. PMID: 20587701
- Inhibition of breast cancer cell motility with a non-cyclooxygenase inhibitory derivative of sulindac by suppressing TGFβ/miR-21 signaling. | Yi, B., et al. 2016. Oncotarget. 7: 7979-92. PMID: 26769851
- Comparison of the effects of sulindac with other cyclooxygenase inhibitors on prostaglandin excretion and renal function in normal and chronic bile duct-ligated dogs and swine. | Zambraski, EJ., et al. 1984. J Pharmacol Exp Ther. 228: 560-6. PMID: 6423807
- Antineoplastic drugs sulindac sulfide and sulfone inhibit cell growth by inducing apoptosis. | Piazza, GA., et al. 1995. Cancer Res. 55: 3110-6. PMID: 7606732
- Differential inhibition of prostaglandin endoperoxide synthase (cyclooxygenase) isozymes by aspirin and other non-steroidal anti-inflammatory drugs. | Meade, EA., et al. 1993. J Biol Chem. 268: 6610-4. PMID: 8454631
- Sulindac sulfide inhibits Ras signaling. | Herrmann, C., et al. 1998. Oncogene. 17: 1769-76. PMID: 9778042
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Sulindac sulfide, 5 mg | sc-200118 | 5 mg | $73.00 | |||
Sulindac sulfide, 25 mg | sc-200118A | 25 mg | $226.00 |