Molecular structure of Tenidap, CAS Number: 120210-48-2
Tenidap (CAS 120210-48-2)
See product citations (1)
Alternate Names:
CP 66248
Application:
Tenidap is a 5-LO and selective Cox-1 inhibitor
CAS Number:
120210-48-2
Purity:
≥99%
Molecular Weight:
320.75
Molecular Formula:
C14H9N2O3SCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Tenidap, also known as CP 66248, is reported to be an anti-inflammatory agent that reduces A 23187-stimulated Leukotriene B4 (LTB4, sc-201043) and prostaglandin E2 (PGE2, sc-201225) synthesis. Tenidap is shown to inhibit 5-LO (5-lipoxygenase) as well as selectively inhibit Cox-1 (IC50 of < 0.03 muM) over Cox-2 (IC50 of < 1.2 muM). Experiments show that Tenidap also potently potentiates 86Rb+ efflux through hKir2.3 channels on Chinese hamster ovary cells in vitro.
Tenidap (CAS 120210-48-2) References
- Tenidap, a novel anti-inflammatory agent, is an opener of the inwardly rectifying K+ channel hKir2.3. | Liu, Y., et al. 2002. Eur J Pharmacol. 435: 153-60. PMID: 11821021
- Tenidap is neuroprotective in a pilocarpine rat model of temporal lobe epilepsy. | Tang, XH., et al. 2013. Chin Med J (Engl). 126: 1900-5. PMID: 23673107
- CP-66,248, a new anti-inflammatory agent, is a potent inhibitor of leukotriene B4 and prostanoid synthesis in human polymorphonuclear leucocytes in vitro. | Moilanen, E., et al. 1988. Eicosanoids. 1: 35-9. PMID: 2856170
- Reduction of intracellular pH by tenidap. Involvement of cellular anion transporters in the pH change. | McNiff, P., et al. 1995. Biochem Pharmacol. 50: 1421-32. PMID: 7503793
- Tenidap: a novel cytokine-modulating antirheumatic drug for the treatment of rheumatoid arthritis. | Breedveld, F. 1994. Scand J Rheumatol Suppl. 100: 31-44. PMID: 7532319
- The pharmacokinetics of tenidap sodium: introduction. | Pullar, T. 1995. Br J Clin Pharmacol. 39 Suppl 1: 1S-2S. PMID: 7547085
- Single and multiple dose pharmacokinetics of tenidap sodium in healthy subjects. | Gardner, MJ., et al. 1995. Br J Clin Pharmacol. 39 Suppl 1: 11S-15S. PMID: 7547086
- Tenidap modulates cytoplasmic pH and inhibits anion transport in vitro. I. Mechanism and evidence of functional significance. | McNiff, P., et al. 1994. J Immunol. 153: 2180-93. PMID: 8051419
- Tenidap, a structurally novel drug for the treatment of arthritis: antiinflammatory and analgesic properties. | Moore, PF., et al. 1996. Inflamm Res. 45: 54-61. PMID: 8907585
- Effects of tenidap on intracellular signal transduction and the induction of proinflammatory cytokines: a review. | Bondeson, J. 1996. Gen Pharmacol. 27: 943-56. PMID: 8909974
- Tenidap inhibits 5-lipoxygenase product formation in vitro, but this activity is not observed in three animal models. | Carty, TJ., et al. 1997. Inflamm Res. 46: 168-79. PMID: 9197987
- Evaluation of the antiinflammatory activity of a dual cyclooxygenase-2 selective/5-lipoxygenase inhibitor, RWJ 63556, in a canine model of inflammation. | Kirchner, T., et al. 1997. J Pharmacol Exp Ther. 282: 1094-101. PMID: 9262379
- Tenidap enhances P2Z/P2X7 receptor signalling in macrophages. | Sanz, JM., et al. 1998. Eur J Pharmacol. 355: 235-44. PMID: 9760038
Inhibitor of:
Cox-2.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Tenidap, 10 mg | sc-204334 | 10 mg | $163.00 | |||
Tenidap, 50 mg | sc-204334A | 50 mg | $592.00 |