Molecular structure of (S)-(+)-Flurbiprofen, CAS Number: 51543-39-6
(S)-(+)-Flurbiprofen (CAS 51543-39-6)
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Alternate Names:
(S)-(+)-2-Fluoro-α-methyl-4-biphenylacetic acid
Application:
(S)-(+)-Flurbiprofen is an inhibitor of Cox-1 and Cox-2
CAS Number:
51543-39-6
Molecular Weight:
244.26
Molecular Formula:
C15H13FO2
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
(S)-Flurbiprofen is a nonsteroidal anti-inflammatory compound that functions as an inhibitor of cyclooxygenase, such as COX-1 and COX-2 enzymes. It exerts its mechanism of action by binding to the active site of these enzymes, thereby preventing the conversion of arachidonic acid to prostaglandin H2. This inhibition leads to a decrease in the production of prostaglandins. (S)-Flurbiprofen′s function in experimental applications involves its ability to modulate the inflammatory process by targeting specific enzymes involved in prostaglandin synthesis, thereby influencing cellular signaling pathways related to inflammation.
(S)-(+)-Flurbiprofen (CAS 51543-39-6) References
- Inhibition of NF-kappaB and AP-1 activation by R- and S-flurbiprofen. | Tegeder, I., et al. 2001. FASEB J. 15: 2-4. PMID: 11099482
- S+ -flurbiprofen but not 5-HT1 agonists suppress basal and stimulated CGRP and PGE2 release from isolated rat dura mater. | Zimmermann, K., et al. 2003. Pain. 103: 313-320. PMID: 12791437
- Bioinversion of R-flurbiprofen to S-flurbiprofen at various dose levels in rat, mouse, and monkey. | Leipold, DD., et al. 2004. Chirality. 16: 379-87. PMID: 15190583
- Pharmacokinetic parameters of (R)-(-) and (S)-(+)-flurbiprofen in dairy bovines. | Igarza, L., et al. 2006. Vet Res Commun. 30: 513-22. PMID: 16755363
- Molecular mobility of amorphous S-flurbiprofen: a dielectric relaxation spectroscopy approach. | Rodrigues, AC., et al. 2014. Mol Pharm. 11: 112-30. PMID: 24215236
- Analgesic effect of S (+)-flurbiprofen plaster in a rat model of knee arthritis: analysis of gait and synovial fluid prostaglandin E2 levels. | Fukumoto, A., et al. 2018. J Pharm Pharmacol. 70: 929-936. PMID: 29607510
- The Comparison of Plasma and Cerebrospinal Fluid R(-)- and S(+)-Flurbiprofen Concentration After Intravenous Injection of Flurbiprofen Axetil in Human Subjects. | Yao, H., et al. 2021. Front Pharmacol. 12: 646196. PMID: 33995057
- Comparison of percutaneous permeation profiles of flurbiprofen enantiomers. | Zhang, L., et al. 2022. Chirality. 34: 894-900. PMID: 35411968
- Comparison of efficacy and safety in the combination therapies of duloxetine and S-flurbiprofen plaster, and of duloxetine and conventional NSAIDs for chronic pain in patients with osteoarthritis (OASIS DUAL study). | Koyama, K. 2022. Drug Discov Ther. 16: 217-224. PMID: 36223938
- Antinociceptive effects of R(-)- and S(+)-flurbiprofen on rat spinal dorsal horn neurons rendered hyperexcitable by an acute knee joint inflammation. | Neugebauer, V., et al. 1995. J Pharmacol Exp Ther. 275: 618-28. PMID: 7473147
- New insights into the site and mode of antinociceptive action of flurbiprofen enantiomers. | Geisslinger, G. and Schaible, HG. 1996. J Clin Pharmacol. 36: 513-20. PMID: 8809636
- Biliary excretion and enterohepatic cycling of R- and S-flurbiprofen in the rat. | Eeckhoudt, SL., et al. 1997. Drug Metab Dispos. 25: 428-30. PMID: 9107541
- Peripheral and/or central effects of racemic-, S(+)- and R(-)-flurbiprofen on inflammatory nociceptive processes: a c-Fos protein study in the rat spinal cord. | Buritova, J. and Besson, JM. 1998. Br J Pharmacol. 125: 87-101. PMID: 9776348
Inhibitor of:
Cox-2, and Enzyme.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
(S)-(+)-Flurbiprofen, 10 mg | sc-205503 | 10 mg | $32.00 | |||
(S)-(+)-Flurbiprofen, 50 mg | sc-205503A | 50 mg | $140.00 | |||
(S)-(+)-Flurbiprofen, 1 g | sc-205503B | 1 g | $1025.00 | |||
(S)-(+)-Flurbiprofen, 1.5 g | sc-205503C | 1.5 g | $1841.00 |