Cordon-bleu Inhibitors
Cordon-bleu Inhibitors are a collection of chemical compounds that can indirectly inhibit the function of the Cordon-bleu protein, which plays a crucial role in actin filament assembly. Each of these inhibitors function by influencing the various pathways and mechanisms that control actin dynamics. For example, Latrunculin A and Cytochalasin D disrupt actin dynamics by inhibiting the polymerization of actin into filaments and blocking the addition of further actin monomers to the filaments, respectively. This disruption of actin polymerization and filament formation interferes with Cordon-bleu's ability to promote these processes, effectively inhibiting its function.
Other Cordon-bleu inhibitors, such as Y-27632, NSC 23766, and CK-666, target different components of the signaling pathways that regulate actin dynamics. Y-27632 is a selective inhibitor of ROCK, a downstream effector of Rho GTPase involved in actin-myosin contractility. NSC 23766 inhibits Rac1, a GTPase that regulates actin polymerization, while CK-666 inhibits the Arp2/3 complex, which nucleates new actin filaments. By disrupting these pathwaysand components, these inhibitors can indirectly affect Cordon-bleu's function. For instance, Y-27632 disrupts actin dynamics through inhibiting ROCK, thereby indirectly weakening Cordon-bleu's ability to promote actin filament assembly.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Latrunculin A, Latrunculia magnifica | 76343-93-6 | sc-202691 sc-202691B | 100 µg 500 µg | $260.00 $799.00 | 36 | |
Latrunculin A binds to actin monomers, preventing their polymerization into filaments. This can inhibit COBL since it relies on actin filament assembly to exert its function. | ||||||
Cytochalasin D | 22144-77-0 | sc-201442 sc-201442A | 1 mg 5 mg | $145.00 $442.00 | 64 | |
Cytochalasin D binds to the plus end of actin filaments, blocking the addition of further actin monomers and leading to filament disassembly. By disrupting actin filaments, it indirectly inhibits COBL's function. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $182.00 $693.00 | 88 | |
Y-27632 is a selective inhibitor of ROCK, a downstream effector of Rho GTPase involved in actin-myosin contractility. By inhibiting ROCK, it disrupts actin dynamics and thus indirectly inhibits COBL. | ||||||
NSC 23766 | 733767-34-5 | sc-204823 sc-204823A | 10 mg 50 mg | $148.00 $597.00 | 75 | |
NSC 23766 is an inhibitor of Rac1, a GTPase that regulates actin polymerization. By inhibiting Rac1, it disrupts actin dynamics and indirectly inhibits COBL. | ||||||
CK 666 | 442633-00-3 | sc-361151 sc-361151A | 10 mg 50 mg | $315.00 $1020.00 | 5 | |
CK-666 is an inhibitor of the Arp2/3 complex, which nucleates new actin filaments. It indirectly inhibits COBL by disrupting actin dynamics. | ||||||
SMIFH2 | 340316-62-3 | sc-507273 | 5 mg | $140.00 | ||
SMIFH2 is a small molecule inhibitor of formins, a family of proteins that nucleate and elongate unbranched actin filaments. This can interfere with the actin filament assembly promoted by COBL. | ||||||
ML-7 hydrochloride | 110448-33-4 | sc-200557 sc-200557A | 10 mg 50 mg | $89.00 $262.00 | 13 | |
ML-7 inhibits myosin light chain kinase, which regulates actin-myosin contractility. It indirectly inhibits COBL by disrupting actin dynamics. | ||||||
(S)-(−)-Blebbistatin | 856925-71-8 | sc-204253 sc-204253A sc-204253B sc-204253C | 1 mg 5 mg 10 mg 25 mg | $71.00 $260.00 $485.00 $949.00 | ||
Blebbistatin is a selective inhibitor of myosin II, which is involved in actin-myosin contractility. By inhibiting myosin II, it disrupts actin dynamics and indirectly inhibits COBL. | ||||||
Wiskostatin | 253449-04-6 | sc-204399 sc-204399A sc-204399B sc-204399C | 1 mg 5 mg 25 mg 50 mg | $48.00 $122.00 $432.00 $812.00 | 4 | |
Wiskostatin is a selective inhibitor of the N-WASP-Arp2/3 pathway, which is crucial for actin polymerization. By inhibiting this pathway, it disrupts actin dynamics and indirectly inhibits COBL. | ||||||
eIF4E/eIF4G Interaction Inhibitor, 4EGI-1 | 315706-13-9 | sc-202597 | 10 mg | $260.00 | 14 | |
SecinH3 is an inhibitor of cytohesins, which are involved in Arf GTPase regulation of actin remodeling. It indirectly inhibits COBL by disrupting actin dynamics. | ||||||