Contactin 4 Activators
Contactin 4 (CNTN4) activators are a class of chemical compounds that can exert an influence on the activity of CNTN4, a protein involved in neuronal functions such as axon guidance, synaptic function, and neuronal cell-cell interactions. These activators include a diverse array of compounds, from vitamins and their metabolites, such as retinoic acid and all-trans retinoic acid (ATRA), to plant-derived compounds like forskolin, and synthetic molecules like rolipram and 8-bromo-cAMP. Each of these compounds can modulate specific cellular pathways that have the potential to influence CNTN4 activity. For instance, retinoic acid and ATRA can activate retinoic acid receptors (RARs) and retinoid X receptors (RXRs), modulating the expression of genes involved inneuronal differentiation and synaptic function, processes in which CNTN4 is involved. Forskolin, rolipram, and 8-Bromo-cAMP, on the other hand, raise cAMP levels in the cell, leading to PKA activation and potential impacts on proteins involved in neuronal functions, including CNTN4.
Other compounds in this class, like L-685,458, IBMX, PD 98059, U0126, KN-93, chelerythrine, and LY294002, function by inhibiting specific enzymes or signaling pathways, thereby exerting indirect effects on CNTN4 activity. For example, L-685,458 inhibits gamma-secretase, potentially altering the processing of proteins related to neuronal functions, and in turn, affecting CNTN4. Similarly, IBMX increases cAMP levels, which can activate PKA, potentially modulating CNTN4. PD 98059 and U0126 inhibit MEK, and KN-93 inhibits CaMKII, altering MAPK and calcium signaling respectively, which can influence proteins like CNTN4. Chelerythrine inhibits PKC, and LY294002 inhibits PI3K, both altering downstream signaling that can affect the expression and function of proteins involved in neuronal functions, including CNTN4. Therefore, these compounds, through their specific actions on different biochemical pathways, can influence the activity of CNTN4, highlighting the complex web of cellular processes that govern CNTN4 regulation.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic acid, a metabolite of vitamin A, regulates gene expression through activation of retinoic acid receptors (RARs) and retinoid X receptors (RXRs). These nuclear receptors, when activated, can modulate the expression of genes related to neuronal differentiation and synaptic function, processes in which Contactin 4 (CNTN4) is known to play a crucial role. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin is a plant-derived compound that activates adenylyl cyclase, leading to increased levels of cyclic AMP (cAMP). High levels of cAMP can stimulate Protein Kinase A (PKA), which in turn can affect the phosphorylation status of many proteins involved in neuronal functions, potentially modulating CNTN4 activity. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $75.00 $212.00 | 18 | |
Rolipram is a selective inhibitor of phosphodiesterase 4 (PDE4), leading to increased cAMP levels. The rise in cAMP levels can affect neuronal functions via PKA activation, potentially influencing CNTN4 activity. | ||||||
8-Bromo-cAMP | 76939-46-3 | sc-201564 sc-201564A | 10 mg 50 mg | $97.00 $224.00 | 30 | |
8-Bromo-cAMP is a cell-permeable cAMP analog. Elevated cAMP levels can stimulate PKA, which can influence the phosphorylation status of many proteins involved in neuronal functions, such as CNTN4. | ||||||
L-685,458 | 292632-98-5 | sc-204042 sc-204042A | 1 mg 5 mg | $337.00 $1000.00 | 4 | |
L-685,458 is a potent and selective inhibitor of gamma-secretase, an enzyme complex that processes various proteins. Inhibition of gamma-secretase can lead to altered processing of proteins involved in neuronal functions, potentially affecting CNTN4. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $159.00 $315.00 $598.00 | 34 | |
IBMX is a non-selective inhibitor of PDE, leading to increased cAMP levels. High cAMP levels can activate PKA, which can influence the phosphorylation status of proteins involved in neuronal functions, potentially modulating CNTN4. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD 98059 is a selective inhibitor of MEK, a kinase involved in the MAPK signaling pathway. Inhibition of MEK can lead to altered downstream signaling, which can influence the expression and function of proteins involved in neuronal functions, such as CNTN4. | ||||||
KN-93 | 139298-40-1 | sc-202199 | 1 mg | $178.00 | 25 | |
KN-93 is a selective inhibitor of CaMKII, a calcium/calmodulin-dependent protein kinase. Inhibition of CaMKII can lead to altered calcium signaling, which can affect the function of proteins involved in neuronal functions, potentially affecting CNTN4. | ||||||
Chelerythrine | 34316-15-9 | sc-507380 | 100 mg | $540.00 | ||
Chelerythrine is a potent and selective inhibitor of Protein Kinase C (PKC). Inhibition of PKC can lead to altered downstream signaling, potentially modulating the function of proteins involved in neuronal functions, such as CNTN4. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a potent inhibitor of phosphatidylinositol 3-kinase (PI3K). Inhibition of PI3K can lead to altered downstream signaling, potentially affecting the expression and function of proteins involved with neuronal functions, possibly including CNTN4. | ||||||