connexin 47 Inhibitors
Connexin 47 inhibitors, encompassing a diverse group of chemicals, primarily target the functionality of gap junction channels. Gap junctions are crucial for direct cytoplasmic communication between neighboring cells. This communication is facilitated by connexin proteins, with Connexin 47 playing a pivotal role in the central nervous system. Several compounds, such as Carbenoxolone and its analog 18-α-Glycyrrhetinic acid, serve as gap junction blockers, interrupting the flow of ions and small molecules between cells.
This interruption can effectively modulate the function of Connexin 47 by preventing the formation of operational gap junction channels. Similarly, Flufenamic acid and Mefenamic acid have been demonstrated to inhibit gap junction communication, presenting another avenue through which Connexin 47 activity can be affected. Notably, peptides like Gap 27 and Gap 26 are specifically designed to disrupt connexin-mediated communication, providing more targeted inhibition.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Carbenoxolone disodium | 7421-40-1 | sc-203868 sc-203868A sc-203868B sc-203868C | 1 g 5 g 10 g 25 g | $46.00 $201.00 $358.00 $774.00 | 1 | |
A gap junction blocker. Inhibits gap junction communication which can interfere with the function of connexin proteins, including Connexin 47. | ||||||
18 β-Glycyrrhetinic Acid | 471-53-4 | sc-205573B sc-205573 sc-205573A sc-205573C sc-205573D | 1 g 5 g 10 g 25 g 100 g | $29.00 $55.00 $87.00 $132.00 $319.00 | 3 | |
Analog of Carbenoxolone and a gap junction blocker. By inhibiting gap junctions, it can indirectly modulate Connexin 47 functionality. | ||||||
2-APB | 524-95-8 | sc-201487 sc-201487A | 20 mg 100 mg | $28.00 $53.00 | 37 | |
Affects IP3R-mediated calcium release which can influence cellular processes that indirectly modulate gap junction activity, thereby affecting Connexin 47 functionality. | ||||||
Flufenamic acid | 530-78-9 | sc-205699 sc-205699A sc-205699B sc-205699C | 10 g 50 g 100 g 250 g | $27.00 $79.00 $154.00 $309.00 | 1 | |
that has been shown to inhibit gap junction communication. Its action can interfere with the role of Connexin 47 in gap junction formation. | ||||||
Mefenamic acid | 61-68-7 | sc-205380 sc-205380A | 25 g 100 g | $106.00 $208.00 | 6 | |
NSAID which acts as a gap junction blocker. It can inhibit the function of connexins, including Connexin 47, by blocking their ability to form functional gap junction channels. | ||||||
1-Heptanol | 111-70-6 | sc-237561 | 100 ml | $113.00 | ||
An aliphatic alcohol that blocks gap junction communication. It can hinder the function of connexins, including Connexin 47. | ||||||
1-Octanol | 111-87-5 | sc-255858 | 1 ml | $46.00 | ||
An aliphatic alcohol similar to Heptanol, known to block gap junction communication. Its action can interfere with Connexin 47-mediated gap junction formation. | ||||||
Quinine | 130-95-0 | sc-212616 sc-212616A sc-212616B sc-212616C sc-212616D | 1 g 5 g 10 g 25 g 50 g | $79.00 $104.00 $166.00 $354.00 $572.00 | 1 | |
Alkaloid that blocks gap junction communication. Its action can inhibit the function of various connexins, potentially including Connexin 47. | ||||||