Date published: 2026-4-21

1-800-457-3801

SCBT Portrait Logo
Seach Input

COMT Antibodies

Santa Cruz Biotechnology features a diverse variety of COMT monoclonal antibodies for investigating catechol-O-methyltransferase (COMT) function and regulation. COMT Antibodies are available for multiple applications, including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), flow cytometry (FCM), and enzyme-linked immunosorbent assay (ELISA). COMT plays a central role in the metabolism of catecholamines, such as dopamine, epinephrine, and norepinephrine, by catalyzing their methylation. The enzymatic activity of catechol-O-methyltransferase maintains neurotransmitter balance in the body. Research has shown COMT involvement in various neurological and psychiatric disorders, including schizophrenia and mood disorders. Understanding catechol-O-methyltransferase function continues to be an important focus in developing therapeutic strategies for treating neurological conditions. Investigating COMT expression patterns helps reveal its role in different tissues and cellular compartments. Exploring COMT regulation provides insights into how cells control neurotransmitter levels. Santa Cruz Biotechnology monoclonal antibodies enable researchers to advance scientific understanding of catechol-O-methyltransferase in health and disease, supporting progress in neuroscience and therapeutic development.

SEE ALSO...

COMT Antibodies

Empty Table HeaderProduct NameCATALOG #ISOTYPEEPITOPEAPPLICATIONSSpeciesCitationsRATING

COMT Antibody (G-4)

sc-137253mouse IgG2b κFL (h)WB, IP, IF, ELISAh
4
(3)

COMT Antibody (4)

sc-135872mouse IgG126-141 (m)WB, IP, IFm, r
1
(2)

COMTD1 Antibody (C-5)

sc-515490mouse IgG2a κ78-181 (h)WB, IP, IF, ELISAm, r, h
1
(1)

COMT CRISPR Knockout, HDR and Double Nickase Plasmids

Empty Table HeaderProduct NameCATALOG #SpeciesAPPLICATIONSMARKERCitationsRATING

COMT CRISPR/Cas9 KO Plasmid (h)

sc-401823hGene KnockoutGFP0
(0)

COMT HDR Plasmid (h)

sc-401823-HDRhHomology Directed RepairPuromycin0
(0)

COMT Double Nickase Plasmid (h)

sc-401823-NIChGene KnockoutPuromycin0
(0)

COMT Double Nickase Plasmid (h2)

sc-401823-NIC-2hGene KnockoutPuromycin0
(0)

COMT siRNA, shRNA Plasmid and shRNA Lentiviral Particle Gene Silencers

Empty Table HeaderProduct NameCATALOG #SpeciesAPPLICATIONSMARKERCitationsRATING

COMT siRNA (h)

sc-43693hGene SilencingN/A0
(0)

COMT shRNA Plasmid (h)

sc-43693-SHhGene SilencingPuromycin0
(0)

COMT shRNA (h) Lentiviral Particles

sc-43693-VhGene SilencingPuromycin0
(0)

COMT siRNA (m)

sc-77372mGene SilencingN/A0
(0)

COMT shRNA Plasmid (m)

sc-77372-SHmGene SilencingPuromycin0
(0)

COMT shRNA (m) Lentiviral Particles

sc-77372-VmGene SilencingPuromycin0
(0)

COMT siRNA (r)

sc-156149rGene SilencingN/A0
(0)

COMTD1 siRNA (h)

sc-90777hGene SilencingN/A0
(0)

COMTD1 shRNA Plasmid (h)

sc-90777-SHhGene SilencingPuromycin0
(0)

COMTD1 shRNA (h) Lentiviral Particles

sc-90777-VhGene SilencingPuromycin0
(0)