COMT Activators
COMT activators represent a diverse array of chemicals that directly or indirectly enhance the activity of Catechol-O-methyltransferase (COMT), a crucial enzyme involved in the metabolism of catecholamines, such as dopamine, norepinephrine, and epinephrine. Entacapone, Tolcapone, and Nitecapone activate COMT by inhibiting its degradation, disrupting the breakdown of the enzyme and resulting in increased catecholamine metabolism. Substrates like 3,4-Dihydroxyphenylacetic acid, 3,4-Dihydroxyphenethylamine (dopamine), and Pyrogallol directly participate in the enzymatic reaction, serving as substrates for COMT. This direct involvement activates COMT, leading to increased metabolism of catecholamines and modulation of cellular processes influenced by these neurotransmitters.
Adenosine, Resveratrol, and 2-Methoxyestradiol activate COMT indirectly by modulating intracellular signaling pathways. These compounds influence cellular processes that lead to the activation or modulation of COMT, impacting catecholamine metabolism and related physiological functions. Sinapic acid and Resorcinol serve as substrates for COMT, directly participating in the enzymatic reaction and activating the enzyme. Apomorphine indirectly activates COMT by modulating dopamine receptors, affecting cellular signaling pathways that lead to the activation or modulation of COMT. The chemical class of COMT activators encompasses a spectrum of compounds that provide researchers with valuable tools to selectively modulate COMT activity, contributing to a deeper understanding of catecholamine metabolism and its role in various physiological processes.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Tolcapone | 134308-13-7 | sc-220266 | 10 mg | $167.00 | 1 | |
Tolcapone activates COMT similarly to Entacapone by inhibiting its degradation. By preventing the breakdown of COMT, Tolcapone enhances the enzyme's activity, resulting in increased catecholamine metabolism. | ||||||
3,4-Dihydroxyphenylacetic acid | 102-32-9 | sc-232010 | 5 g | $20.00 | 3 | |
3,4-Dihydroxyphenylacetic acid acts as a substrate for COMT, directly participating in the enzymatic reaction. By serving as a substrate, this compound activates COMT and facilitates the metabolism of catecholamines, influencing cellular processes regulated by these neurotransmitters. | ||||||
Dopamine | 51-61-6 | sc-507336 | 1 g | $290.00 | ||
3,4-Dihydroxyphenethylamine, also known as dopamine, serves as a substrate for COMT, directly participating in the enzymatic reaction. By acting as a substrate, dopamine activates COMT, leading to increased catecholamine metabolism and modulation of cellular processes influenced by these neurotransmitters. | ||||||
Adenosine | 58-61-7 | sc-291838 sc-291838A sc-291838B sc-291838C sc-291838D sc-291838E sc-291838F | 1 g 5 g 100 g 250 g 1 kg 5 kg 10 kg | $34.00 $48.00 $300.00 $572.00 $1040.00 $2601.00 $4682.00 | 1 | |
Adenosine indirectly activates COMT by modulating adenosine receptors. The activation of these receptors influences cellular signaling pathways, ultimately leading to the activation or modulation of COMT and affecting catecholamine metabolism. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol activates COMT by modulating intracellular signaling pathways. This compound influences cellular processes that indirectly lead to the activation or modulation of COMT, affecting catecholamine metabolism and related physiological functions. | ||||||
2-Methoxyestradiol | 362-07-2 | sc-201371 sc-201371A | 10 mg 50 mg | $71.00 $288.00 | 6 | |
2-Methoxyestradiol activates COMT by modulating intracellular signaling pathways. This compound influences cellular processes that indirectly lead to the activation or modulation of COMT, affecting catecholamine metabolism and related physiological functions. | ||||||
Resorcinol | 108-46-3 | sc-203371 sc-203371A sc-203371B | 100 g 500 g 25 g | $57.00 $209.00 $31.00 | 1 | |
Resorcinol activates COMT by serving as a substrate for the enzyme. As a substrate, resorcinol directly participates in the enzymatic reaction, leading to the activation of COMT and increased metabolism of catecholamines, impacting cellular processes regulated by these neurotransmitters. | ||||||
(R)-(−)-Apomorphine | 58-00-4 | sc-480060 sc-480060A | 25 mg 100 mg | $374.00 $2809.00 | ||
Apomorphine indirectly activates COMT by modulating dopamine receptors. The activation of these receptors influences cellular signaling pathways, ultimately leading to the activation or modulation of COMT and affecting catecholamine metabolism. | ||||||