COMTD1 Antibody (C-5): sc-515490
- COMTD1 Antibody (C-5) is a mouse monoclonal IgG2a κ COMTD1 antibody, cited in 1 publications, provided at 200 µg/ml
- raised against amino acids 78-181 mapping within an internal region of COMTD1 of human origin
- COMTD1 Antibody (C-5) is recommended for detection of COMTD1 of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-COMTD1 Antibody (C-5) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for COMTD1 Antibody (C-5) for WB applications. These reagents are now offered in bundles with COMTD1 Antibody (C-5) (see ordering information below).
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COMTD1 Antibody (C-5) is a mouse monoclonal IgG2a kappa light chain antibody that detects COMTD1 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). COMTD1 (C-5) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. The catechol O-methyltransferase domain-containing protein 1 (COMTD1) is a 262 amino acid single-pass type II membrane protein that plays a significant role in the methylation of catecholamines, which is essential for regulating dopaminergic signaling in the central nervous system. COMTD1 is crucial for the detoxification of catecholamine neurotransmitters, as COMTD1 catalyzes their inactivation, thereby influencing various physiological processes, including mood regulation and cognitive function. A Val158Met polymorphism in the COMT gene can alter enzyme activity, impacting the efficiency of the prefrontal cortex and potentially affecting cognitive performance. COMTD1 exists as a homodimer and is encoded by a gene located on human chromosome 10q22.21, highlighting evolutionary significance and potential implications in neuropsychiatric disorders.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
COMTD1 Antibody (C-5) References:
- Assay of catechol-O-methyltransferase activity in human erythrocytes using norepinephrine as a natural substrate. | Masuda, M., et al. 2002. Ann Clin Biochem. 39: 589-94. PMID: 12564841
- CNS dopamine oxidation and catechol-O-methyltransferase: importance in the etiology, pharmacotherapy, and dietary prevention of Parkinson's disease. | Zhu, BT. 2004. Int J Mol Med. 13: 343-53. PMID: 14767563
- Catechol-o-methyltransferase inhibition improves set-shifting performance and elevates stimulated dopamine release in the rat prefrontal cortex. | Tunbridge, EM., et al. 2004. J Neurosci. 24: 5331-5. PMID: 15190105
- Catecholamines block the antimitogenic effect of estradiol on human coronary artery smooth muscle cells. | Dubey, RK., et al. 2004. J Clin Endocrinol Metab. 89: 3922-31. PMID: 15292328
- Polymorphisms in the catechol-O-methyltransferase (COMT) gene influence plasma total homocysteine levels. | Tunbridge, EM., et al. 2008. Am J Med Genet B Neuropsychiatr Genet. 147B: 996-9. PMID: 18189241
- COMT polymorphisms affecting protein expression are risk factors for endometrial cancer. | Hirata, H., et al. 2008. Mol Carcinog. 47: 768-74. PMID: 18324659
- Val158Met polymorphism in the catechol-O-methyltransferase (COMT) gene is not associated with tardive dyskinesia in schizophrenia. | Kang, SG., et al. 2008. Neuropsychobiology. 57: 22-5. PMID: 18424907
- COMT Val108/158Met polymorphism and the modulation of task-oriented behavior in children with ADHD. | Sengupta, S., et al. 2008. Neuropsychopharmacology. 33: 3069-77. PMID: 18580877
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
COMTD1 Antibody (C-5) | sc-515490 | 200 µg/ml | $322.00 | |||
COMTD1 Antibody (C-5): m-IgG Fc BP-HRP Bundle | sc-531390 | 200 µg Ab; 10 µg BP | $361.00 | |||
COMTD1 Antibody (C-5): m-IgGκ BP-HRP Bundle | sc-525068 | 200 µg Ab, 40 µg BP | $361.00 | |||
COMTD1 Antibody (C-5) AC | sc-515490 AC | 500 µg/ml, 25% agarose | $424.00 | |||
COMTD1 Antibody (C-5) HRP | sc-515490 HRP | 200 µg/ml | $322.00 | |||
COMTD1 Antibody (C-5) FITC | sc-515490 FITC | 200 µg/ml | $336.00 | |||
COMTD1 Antibody (C-5) PE | sc-515490 PE | 200 µg/ml | $349.00 | |||
COMTD1 Antibody (C-5) Alexa Fluor® 488 | sc-515490 AF488 | 200 µg/ml | $364.00 | |||
COMTD1 Antibody (C-5) Alexa Fluor® 546 | sc-515490 AF546 | 200 µg/ml | $364.00 | |||
COMTD1 Antibody (C-5) Alexa Fluor® 594 | sc-515490 AF594 | 200 µg/ml | $364.00 | |||
COMTD1 Antibody (C-5) Alexa Fluor® 647 | sc-515490 AF647 | 200 µg/ml | $364.00 | |||
COMTD1 Antibody (C-5) Alexa Fluor® 680 | sc-515490 AF680 | 200 µg/ml | $364.00 | |||
COMTD1 Antibody (C-5) Alexa Fluor® 790 | sc-515490 AF790 | 200 µg/ml | $364.00 |