COL20A1 Activators
COL20A1, a gene encoding for collagen type XX alpha 1 chain, is nestled within the intricate world of fibrillar collagens. While direct activators specific to this protein are scant, various chemicals indirectly modulate pathways germane to collagen synthesis and function, suggesting possible intersections with COL20A1. Retinoic acid, wielding the power to modulate gene expression connected to collagen synthesis, offers a potential lever to tweak COL20A1 expression. Ascorbic acid, indispensable for collagen's hydroxylation processes, and its analog, 2-Phospho-L-ascorbic acid trisodium salt, both bolster the synthetic mechanisms that could extend to COL20A1.
Compounds like Copper (II) Sulfate and Zinc sulfate, pivotal for enzyme activities within the collagen synthesis cascade, could indirectly buttress COL20A1's synthesis. On the substrate front, the amino acids Glycine and Proline, fundamental building blocks for collagen, can ensure the efficient formation of COL20A1. In the realm of modulators, A-83-01 and Dimethyloxalylglycine (DMOG) operate on distinct pathways - TGF-beta signaling and hypoxia-induced collagen synthesis, respectively.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic acid is known to regulate gene expression involved in collagen synthesis. It can potentially enhance the expression of COL20A1. | ||||||
L-Ascorbic acid, free acid | 50-81-7 | sc-202686 | 100 g | $46.00 | 5 | |
Essential for hydroxylation of proline residues during collagen synthesis. Increased availability can upregulate collagen production, including COL20A1. | ||||||
Copper(II) sulfate | 7758-98-7 | sc-211133 sc-211133A sc-211133B | 100 g 500 g 1 kg | $46.00 $122.00 $189.00 | 3 | |
Copper is crucial for lysyl oxidase activity, an enzyme essential for collagen cross-linking. This might indirectly stimulate COL20A1 synthesis. | ||||||
A 83-01 | 909910-43-6 | sc-203791 sc-203791A | 10 mg 50 mg | $202.00 $811.00 | 16 | |
Inhibitor of TGF-beta type I receptor. By modulating TGF-beta signaling, it can indirectly influence collagen production and possibly COL20A1. | ||||||
Dimethyloxaloylglycine (DMOG) | 89464-63-1 | sc-200755 sc-200755A sc-200755B sc-200755C | 10 mg 50 mg 100 mg 500 mg | $84.00 $301.00 $374.00 $779.00 | 25 | |
Stabilizes HIF-1α, an inducer of collagen production under hypoxic conditions, potentially affecting COL20A1 synthesis. | ||||||
Glycine | 56-40-6 | sc-29096A sc-29096 sc-29096B sc-29096C | 500 g 1 kg 3 kg 10 kg | $41.00 $71.00 $112.00 $357.00 | 15 | |
A primary amino acid in collagen triple helix formation. Adequate glycine can ensure efficient collagen synthesis, including COL20A1. | ||||||
L-Proline | 147-85-3 | sc-397196 sc-397196A sc-397196B sc-397196C | 25 g 100 g 1 kg 5 kg | $38.00 $133.00 $208.00 $978.00 | ||
Important for collagen stability. Its presence can foster proper collagen formation, potentially influencing COL20A1. | ||||||
L-Mimosine | 500-44-7 | sc-201536A sc-201536B sc-201536 sc-201536C | 25 mg 100 mg 500 mg 1 g | $36.00 $88.00 $220.00 $436.00 | 8 | |
An inhibitor of the enzyme prolyl hydroxylase, affecting collagen synthesis. This might indirectly modulate COL20A1 synthesis. | ||||||
3-Aminopropionitrile | 151-18-8 | sc-266473 | 1 g | $104.00 | ||
Inhibits lysyl oxidase, potentially altering collagen cross-linking and indirectly influencing COL20A1 synthesis. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $48.00 | ||
Zinc is crucial for several enzymes involved in collagen synthesis, potentially promoting COL20A1 synthesis. | ||||||