COL14A1 Activators
COL14A1 Activators encompass a diverse array of chemical compounds that engage in the biochemical enhancement of COL14A1's functional activity through several distinct pathways and processes. Ascorbic Acid, for example, is critical for the hydroxylation of proline residues in collagen; this process is indispensable for the proper formation and stabilization of the collagen triple helix, of which COL14A1 is a constituent. Copper Sulfate and Manganese(II) Chloride act as cofactors for enzymes like lysyl oxidase and prolidase, respectively, which play roles in the post-translational modification and turnover of collagen fibers, thereby ensuring the structural integrity and ongoing synthesis crucial for the function of COL14A1. Similarly, compounds Genipin enhance COL14A1 activity by modulating the cross-linking and stability of collagen fibers, which can be particularly significant during tissue repair and remodeling.
Further, compounds such as Lysophosphatidic Acid (LPA) stimulate fibroblast activity, leading to increased collagen synthesis and secretion, indirectly promoting the activity of COL14A1 in the extracellular matrix. Anthocyanins and Retinoic Acid drive the proliferation and differentiation of skin cells, thereby enhancing collagen production and, by extension, the activity of COL14A1 in skin health. Tannic Acid's interaction with collagen fibers increases their resistance to degradation and strengthens their tensile properties, indirectly contributing to the enhancement of COL14A1's structural role. Lastly, the fundamental collagen building blocks, Glycine and Proline, are supplied exogenously to augment the synthesis and structural stability of COL14A1, ensuring the mechanical properties of connective tissues are maintained. Collectively, these activators operate through intricate cellular and molecular mechanisms that culminate in the reinforced function of COL14A1, a protein integral to the structural and regulatory framework of the extracellular matrix in various tissues.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
L-Ascorbic acid, free acid | 50-81-7 | sc-202686 | 100 g | $46.00 | 5 | |
Ascorbic acid is crucial for the hydroxylation of proline residues in collagen, a process essential for the stability and maturation of collagen fibers. By promoting proline hydroxylation, ascorbic acid directly enhances the functional activity of COL14A1 by ensuring proper collagen synthesis and stabilization of the triple helix structure. | ||||||
Copper(II) sulfate | 7758-98-7 | sc-211133 sc-211133A sc-211133B | 100 g 500 g 1 kg | $46.00 $122.00 $189.00 | 3 | |
Copper is a cofactor for lysyl oxidase, which cross-links collagen molecules. Adequate copper levels, provided by copper sulfate, can ensure the proper function of lysyl oxidase, indirectly enhancing the stability and strength of collagen networks where COL14A1 is integrated. | ||||||
Manganese(II) chloride beads | 7773-01-5 | sc-252989 sc-252989A | 100 g 500 g | $19.00 $31.00 | ||
Manganese ions are cofactors for prolidase, an enzyme involved in the recycling of proline from collagen breakdown. By supporting prolidase activity, manganese(II) chloride indirectly promotes the availability of proline for new COL14A1 synthesis, enhancing its functional activity in connective tissue health. | ||||||
Genipin | 6902-77-8 | sc-203057 sc-203057A | 25 mg 100 mg | $82.00 $246.00 | 6 | |
Genipin is a natural crosslinker for proteins and can be used to crosslink collagen. This compound enhances the stability and resistance of collagen fibers to enzymatic degradation, indirectly augmenting the functional activity of COL14A1 by reinforcing the structural integrity of its fibrils. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic acid influences skin cell proliferation and differentiation and has been shown to increase collagen production. By promoting the synthesis of collagen, it indirectly enhances the functional activity of COL14A1 in skin health and repair mechanisms. | ||||||
Gallotannin | 1401-55-4 | sc-202619 sc-202619A sc-202619B sc-202619C sc-202619D sc-202619E sc-202619F | 1 g 10 g 100 g 250 g 1 kg 2.5 kg 5 kg | $26.00 $37.00 $67.00 $78.00 $234.00 $536.00 $983.00 | 12 | |
Gallotannin (Tannic acid) can interact with collagen, increasing its resistance to enzymatic degradation and enhancing tensile strength. This interaction can indirectly enhance the functional activity of COL14A1 by stabilizing the collagen fibrils it forms, contributing to the integrity of the extracellular matrix. | ||||||
Glycine | 56-40-6 | sc-29096A sc-29096 sc-29096B sc-29096C | 500 g 1 kg 3 kg 10 kg | $41.00 $71.00 $112.00 $357.00 | 15 | |
Glycine is a major constituent of collagen. By providing an essential building block for collagen synthesis, exogenous glycine can indirectly enhance the production and function of COL14A1, supporting the structural and regulatory roles of collagen in various tissues. | ||||||
L-Proline | 147-85-3 | sc-397196 sc-397196A sc-397196B sc-397196C | 25 g 100 g 1 kg 5 kg | $38.00 $133.00 $208.00 $978.00 | ||
Proline is another primary amino acid in collagen. Supplementing with proline can support collagen synthesis, indirectly enhancing the functional activity of COL14A1 by promoting the formation of its triple helix structure and stability, which is essential for the mechanical properties of connective tissues. | ||||||