CNOT3 Inhibitors
CNOT3 inhibitors belong to a specific class of chemical compounds designed to target and modulate the activity of the Cellular Notch Transcription Complex Subunit 3 (CNOT3). CNOT3 is an essential component of the CCR4-NOT complex, a multi-subunit protein assembly that plays a crucial role in post-transcriptional gene regulation and mRNA degradation. This complex is involved in controlling gene expression by regulating mRNA stability, translation, and transcriptional elongation. CNOT3 itself functions as a scaffold protein within the CCR4-NOT complex, facilitating its interactions with other subunits and thereby influencing the overall functionality of the complex. CNOT3 inhibitors are synthetic or natural compounds specifically designed to disrupt or inhibit the activity of CNOT3, with the ultimate goal of modulating gene expression and potentially targeting specific cellular processes.
CNOT3 inhibitors have gained significance in recent years due to the growing recognition of the CCR4-NOT complex's pivotal role in cellular processes, including cell cycle regulation, RNA metabolism, and differentiation. By targeting CNOT3, these inhibitors can potentially provide insights into the molecular mechanisms of gene regulation and may have implications in various research fields, such as molecular biology, genetics, and cell biology.
SEE ALSO...
Items 1 to 10 of 12 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Leptomycin B | 87081-35-4 | sc-358688 sc-358688A sc-358688B | 50 µg 500 µg 2.5 mg | $107.00 $416.00 $1248.00 | 35 | |
Inhibits nuclear export by binding to exportin 1 (CRM1), potentially increasing mRNA retention in the nucleus, indirectly affecting CNOT3 function in mRNA decay. | ||||||
Actinomycin D | 50-76-0 | sc-200906 sc-200906A sc-200906B sc-200906C sc-200906D | 5 mg 25 mg 100 mg 1 g 10 g | $74.00 $243.00 $731.00 $2572.00 $21848.00 | 53 | |
Interferes with transcriptional processes by binding to DNA and thus may reduce the substrate availability for CNOT3-mediated mRNA decay. | ||||||
Triptolide | 38748-32-2 | sc-200122 sc-200122A | 1 mg 5 mg | $90.00 $204.00 | 13 | |
Acts on multiple transcription factors and could decrease overall mRNA production, affecting the downstream CNOT3-related processes. | ||||||
DRB | 53-85-0 | sc-200581 sc-200581A sc-200581B sc-200581C | 10 mg 50 mg 100 mg 250 mg | $43.00 $189.00 $316.00 $663.00 | 6 | |
Inhibits RNA Polymerase II, thereby reducing mRNA synthesis and indirectly impacting CNOT3 activity. | ||||||
Flavopiridol | 146426-40-6 | sc-202157 sc-202157A | 5 mg 25 mg | $78.00 $259.00 | 41 | |
Cyclin-dependent kinase inhibitor that can suppress transcription, potentially reducing the load on mRNA decay mechanisms involving CNOT3. | ||||||
Cordycepin | 73-03-0 | sc-203902 | 10 mg | $101.00 | 5 | |
Adenosine analog that inhibits polyadenylation, which may indirectly reduce the efficiency of CNOT3 in mRNA decay. | ||||||
α-Amanitin | 23109-05-9 | sc-202440 sc-202440A | 1 mg 5 mg | $269.00 $1050.00 | 26 | |
Inhibits RNA polymerase II and thus could decrease the pool of mRNA available for CNOT3 action. | ||||||
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $99.00 $259.00 | 36 | |
Inhibits peptidyl transferase activity of the 60S ribosomal subunit, leading to inhibition of protein synthesis and potential indirect effects on CNOT3-related pathways. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
A flavonoid with various cellular effects, including modulation of transcription factors and signaling pathways that could indirectly affect CNOT3 function. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $60.00 $265.00 $1000.00 | 163 | |
Proteasome inhibitor that can lead to altered protein turnover, possibly influencing CNOT3-related pathways due to changes in cellular regulation. | ||||||