clone 19 Activators
Clone 19 Activators encompass a diverse array of chemical compounds that indirectly bolster the functional activity of Clone 19 through distinct signaling pathways. For instance, Forskolin and Isoproterenol both function through the adenylyl cyclase-cAMP-PKA axis, with Forskolin directly activating adenylyl cyclase and Isoproterenol engaging beta-adrenergic receptors, culminating in the activation of PKA which may phosphorylate Clone 19 or its associated proteins, thereby enhancing its functionality. Similarly, PMA and Ionomycin exert their effects via PKC and calcium-dependent kinase pathways, respectively, with PMA serving as a PKC activator potentially responsible for the phosphorylation of Clone 19, and Ionomycin elevating intracellular calcium to activate kinases that may target Clone 19. Sildenafil, by inhibiting PDE5, raises cAMP and cGMP levels, indirectly facilitating Clone 19 activity through PKA or PKG pathways, while 8-Bromo-cAMP, a cAMP analog, directly activates PKA, potentially leading to enhanced Clone 19 activity.
Further, the functional repertoire of Clone 19 is augmented by EGCG, a tyrosine kinase inhibitor that may reduce competitive phosphorylation signaling, allowing Clone 19 to exhibit increased activity. Anisomycin, by activating stress-activated protein kinases, may lead to phosphorylation events that enhance Clone 19 activity. MAPK pathway modulators such as SB 203580 and U0126, by inhibiting p38 and MEK1/2 respectively, may relieve inhibitory feedback loops and shift signaling dynamics to favor Clone 19's function, thus indirectly enhancing its activity. Additionally, LY294002, a PI3K inhibitor, and A23187, another calcium ionophore, can influence upstream or parallel signaling pathways or increase intracellular calcium levels, respectively, which may result in the activation of pathways that enhance Clone 19's role in cellular signaling, emphasizing the multifaceted nature of Clone 19 activators and their potential to indirectly enhance the protein's function through various biochemical mechanisms.
Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin directly activates adenylate cyclase, thereby increasing intracellular cAMP levels. Elevated cAMP can activate PKA, which may phosphorylate and thus enhance the activity of Clone 19 by modulating its conformation or interaction with other proteins. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA is a potent activator of protein kinase C (PKC), which can lead to the phosphorylation of Clone 19 or associated regulatory proteins, thereby enhancing Clone 19's functional activity. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $78.00 $270.00 | 80 | |
Ionomycin acts as a calcium ionophore, increasing intracellular calcium levels, which can activate calcium-dependent protein kinases that could phosphorylate and enhance the activity of Clone 19. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $28.00 $38.00 | 5 | |
Isoproterenol is a beta-adrenergic agonist that increases cAMP levels through stimulation of beta-adrenergic receptors, potentially leading to PKA activation and subsequent enhancement of Clone 19 activity. | ||||||
8-Bromo-cAMP | 76939-46-3 | sc-201564 sc-201564A | 10 mg 50 mg | $126.00 $328.00 | 30 | |
8-Bromo-cAMP is a cell-permeable cAMP analog that activates PKA. PKA can then phosphorylate Clone 19 or its associated proteins, potentially enhancing its activity. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
EGCG is a tyrosine kinase inhibitor that could lead to enhanced Clone 19 activity by reducing competitive phosphorylation signaling, thus allowing Clone 19 to be more active. | ||||||
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $99.00 $259.00 | 36 | |
Anisomycin is a protein synthesis inhibitor that can activate stress-activated protein kinases (SAPKs), which may lead to the phosphorylation and activation of Clone 19 directly or indirectly. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $90.00 $349.00 | 284 | |
SB 203580 is a p38 MAPK inhibitor that could enhance Clone 19 activity by modulating the MAPK pathway, potentially shifting signaling dynamics to favor Clone 19's function. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $64.00 $246.00 | 136 | |
U0126 is an inhibitor of MEK1/2, part of the MAPK pathway. Inhibition of MEK may relieve negative feedback loops, potentially enhancing the activity of Clone 19. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY294002 is a PI3K inhibitor that might enhance Clone 19 activity by altering signaling pathways that are upstream or parallel to Clone 19's activity, thus indirectly enhancing its role. | ||||||