CLN6 Activators
CLN6 Activators are a class of chemical compounds that enhance the functional activity of CLN6, a protein involved in the autophagy-lysosome pathway. Compounds such as Lithium Chloride, Rapamycin, N-Acetylcysteine (NAC), Metformin, and Trehalose are known to stimulate autophagy, and thus, can enhance CLN6 activity by promoting this cellular process. Sodium Phenylbutyrate, which promotes the correct folding and trafficking of proteins, can enhance the activity of CLN6, a transmembrane protein, by promoting its proper folding and trafficking.
Other compounds such as Alisporivir, Bafilomycin A1, Torin1, Tacrolimus, and Verapamil enhance CLN6 activity indirectly by triggering the activation of autophagy. Alisporivir, Bafilomycin A1, Torin1, Tacrolimus, and Verapamil inhibit specific proteins leading to autophagy activation. Alisporivir inhibits Cyclophilin A, Bafilomycin A1 inhibits the V-ATPase enzyme, Torin1 is an mTOR inhibitor, Tacrolimus inhibits FKBP-12, and Verapamil inhibits Calmodulin. By activating autophagy, these compounds can enhance the functional activity of CLN6, which is crucially involved in this cellular process.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium Chloride has been shown to enhance autophagy by inhibiting IMPase activity. Given that CLN6 is involved in the autophagy-lysosome pathway, the activation of autophagy by Lithium Chloride can enhance the activity of CLN6. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Rapamycin is a known activator of autophagy. As CLN6 is involved in the autophagy-lysosome pathway, stimulating autophagy with Rapamycin can lead to enhanced CLN6 activity. | ||||||
N-Acetyl-L-cysteine | 616-91-1 | sc-202232 sc-202232A sc-202232C sc-202232B | 5 g 25 g 1 kg 100 g | $34.00 $74.00 $270.00 $114.00 | 34 | |
NAC is an antioxidant that has been shown to stimulate autophagy. Since CLN6 is involved in the autophagy-lysosome pathway, NAC can enhance the activity of CLN6 by promoting autophagy. | ||||||
Metformin-d6, Hydrochloride | 1185166-01-1 | sc-218701 sc-218701A sc-218701B | 1 mg 5 mg 10 mg | $292.00 $822.00 $1540.00 | 1 | |
Metformin can activate AMPK, which is a known stimulator of autophagy. Given that CLN6 is involved in the autophagy-lysosome pathway, Metformin can enhance the activity of CLN6 by stimulating autophagy. | ||||||
Sodium phenylbutyrate | 1716-12-7 | sc-200652 sc-200652A sc-200652B sc-200652C sc-200652D | 1 g 10 g 100 g 1 kg 10 kg | $77.00 $166.00 $622.00 $5004.00 $32783.00 | 43 | |
Sodium Phenylbutyrate can promote the proper folding and trafficking of proteins. As CLN6 is a transmembrane protein, Sodium Phenylbutyrate can enhance the activity of CLN6 by promoting its correct folding and trafficking. | ||||||
D-(+)-Trehalose Anhydrous | 99-20-7 | sc-294151 sc-294151A sc-294151B | 1 g 25 g 100 g | $30.00 $167.00 $260.00 | 2 | |
Trehalose is a disaccharide that has been shown to induce autophagy. As CLN6 is involved in the autophagy-lysosome pathway, Trehalose can enhance the activity of CLN6 by stimulating autophagy. | ||||||
Bafilomycin A1 | 88899-55-2 | sc-201550 sc-201550A sc-201550B sc-201550C | 100 µg 1 mg 5 mg 10 mg | $98.00 $255.00 $765.00 $1457.00 | 280 | |
Bafilomycin A1 is an inhibitor of the V-ATPase enzyme, which leads to the activation of autophagy. Given that CLN6 is involved in the autophagy-lysosome pathway, Bafilomycin A1 can enhance the activity of CLN6 by promoting autophagy. | ||||||
Torin 1 | 1222998-36-8 | sc-396760 | 10 mg | $245.00 | 7 | |
Torin1 is an mTOR inhibitor that can stimulate autophagy. As CLN6 is involved in the autophagy-lysosome pathway, Torin1 can enhance the activity of CLN6 by stimulating autophagy. | ||||||
FK-506 | 104987-11-3 | sc-24649 sc-24649A | 5 mg 10 mg | $78.00 $151.00 | 9 | |
Tacrolimus can inhibit the protein FKBP-12, which leads to the activation of autophagy. Given that CLN6 is involved in the autophagy-lysosome pathway, Tacrolimus can enhance the activity of CLN6 by promoting autophagy. | ||||||
Verapamil | 52-53-9 | sc-507373 | 1 g | $374.00 | ||
Verapamil can inhibit the protein Calmodulin, which leads to the activation of autophagy. As CLN6 is involved in the autophagy-lysosome pathway, Verapamil can enhance the activity of CLN6 by promoting autophagy. | ||||||