CLIM-2 Activators
The chemicals that have been categorized as CLIM-2 Activators function by modulating a series of intracellular signaling cascades which, in turn, lead to the activation of CLIM-2. Forskolin, by directly activating adenylyl cyclase, increases cAMP levels which stimulate PKA. The activated PKA can phosphorylate transcription factors promoting upregulation of CLIM-2. These pathways positively influence the expression and function of CLIM-2. Anisomycin is another potent activator but of the JNK pathway. This activation results in the stimulation of AP-1, a transcription factor, leading to the upregulation of CLIM-2. EPO, on the other hand, binds to its receptor to initiate the JAK2/STAT5 pathway, culminating in the activation of CLIM-2. Thrombin and Bradykinin activate the MAPK/ERK pathway and PLC/IP3/DAG pathway respectively, through their binding to PARs and bradykinin B2 receptorrespectively, inducing CLIM-2 activity. Angiotensin II, similar to Bradykinin, activates the AT1 receptor stimulating the PLC/IP3/DAG pathway, which contributes to CLIM-2 activation.
Insulin, a critical hormone, binds to its receptor and triggers the PI3K/AKT pathway, leading to the promotion of CLIM-2 activity and expression. PMA activates PKC, leading to the phosphorylation of transcription factors that can upregulate the expression of CLIM-2. A23187 is a calcium ionophore that increases intracellular calcium levels, stimulating calcium-dependent proteins and pathways that can influence CLIM-2 expression. ATP, a ubiquitous energy molecule, also serves in a signaling function via P2Y receptors. Activation of these receptors initiates the PLC/IP3/DAG pathway, positively influencing the activity and expression of CLIM-2. In conclusion, the compounds classified as CLIM-2 Activators function via a diverse array of biochemical pathways. These compounds do not directly bind or interact with CLIM-2. Instead, they modulate various signal transduction pathways and cellular processes, which then indirectly lead to the activation of CLIM-2.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin is a direct activator of adenylyl cyclase, which increases levels of cyclic AMP. Increased cAMP can activate Protein Kinase A (PKA). PKA activation may lead to the phosphorylation and activation of transcription factors that can upregulate the expression of CLIM-2. | ||||||
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $99.00 $259.00 | 36 | |
Anisomycin is a potent activator of the JNK pathway, which can stimulate the activity of AP-1 transcription factor that can upregulate the expression of CLIM-2. | ||||||
Thrombin from human plasma | 9002-04-4 | sc-471713 | 100 U | $235.00 | ||
Thrombin is a potent activator of the proteinase-activated receptors (PARs). Activation of PARs can lead to activation of the MAPK/ERK pathway, which can stimulate the activity and expression of CLIM-2. | ||||||
Bradykinin | 58-82-2 | sc-507311 | 5 mg | $110.00 | ||
Bradykinin is a potent activator of the bradykinin B2 receptor, which can activate the PLC/IP3/DAG pathway. This pathway can stimulate the activity and expression of CLIM-2. | ||||||
Angiotensin II, Human | 4474-91-3 | sc-363643 sc-363643A sc-363643B sc-363643C | 1 mg 5 mg 25 mg 100 mg | $51.00 $100.00 $310.00 $690.00 | 3 | |
Angiotensin II activates the AT1 receptor, which can stimulate the PLC/IP3/DAG pathway. This pathway can stimulate the activity and expression of CLIM-2. | ||||||
Insulin | 11061-68-0 | sc-29062 sc-29062A sc-29062B | 100 mg 1 g 10 g | $156.00 $1248.00 $12508.00 | 82 | |
Insulin binds to the insulin receptor, which activates the PI3K/AKT pathway. This pathway can stimulate the activity and expression of CLIM-2. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA is a potent activator of Protein Kinase C (PKC). Activation of PKC can lead to the phosphorylation and activation of transcription factors that can upregulate the expression of CLIM-2. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $55.00 $131.00 $203.00 $317.00 | 23 | |
A23187 is a calcium ionophore that can increase intracellular calcium levels. Increased calcium can stimulate the activity of calcium-dependent proteins and pathways that can upregulate the expression of CLIM-2. | ||||||
ATP | 56-65-5 | sc-507511 | 5 g | $17.00 | ||
ATP can bind to and activate P2Y receptors, leading to activation of the PLC/IP3/DAG pathway. This pathway can stimulate the activity and expression of CLIM-2. | ||||||