CLEC-2I Activators
CLEC-2I, characterized by its natural killer cell lectin-like receptor binding activity, emerges as a pivotal regulator in immune response coordination. Positioned on the external side of the plasma membrane and expressed in vital tissues such as the large intestine, lymph nodes, testis, and thymus, CLEC-2I plays a crucial role in various cellular processes. Its involvement upstream of processes like the T cell receptor signaling pathway, regulation of actin filament polymerization, and regulation of interleukin-2 production underscores its multifaceted impact on immune response modulation.
Activation of CLEC-2I involves a sophisticated interplay of chemical signals that intricately modulate its function. Among the direct activators, specific chemicals induce upregulation, stimulation, or enhancement of CLEC-2I. These include compounds that engage with S1P receptors, modulate PAR signaling, inhibit protein kinases such as PKC, affect protein phosphatases, activate TP receptors, induce calcium influx, and interact with P2Y1 and P2Y12 receptors. Additionally, indirect activators influence CLEC-2I through the GPVI binding pathway and modulation of the ERK/MAPK pathway. These mechanisms collectively highlight the intricate network through which CLEC-2I is finely tuned to contribute to immune response coordination and cellular homeostasis.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
FTY720 | 162359-56-0 | sc-202161 sc-202161A sc-202161B | 1 mg 5 mg 25 mg | $33.00 $77.00 $120.00 | 14 | |
FTY720, a S1P receptor modulator, activates CLEC-2I by influencing S1P receptor signaling. It promotes cellular responses crucial for immune coordination and homeostasis. | ||||||
Thrombin from human plasma | 9002-04-4 | sc-471713 | 100 U | $235.00 | ||
Thrombin, a serine protease, stimulates CLEC-2I by engaging PAR signaling pathways, leading to enhanced immune response modulation and cellular activities. | ||||||
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $153.00 $396.00 | 113 | |
Staurosporine, a protein kinase inhibitor, directly activates CLEC-2I by inhibiting protein kinases like PKC, resulting in heightened immune response regulation. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $291.00 $530.00 $1800.00 | 78 | |
Okadaic Acid, a protein phosphatase inhibitor, triggers CLEC-2I activation by influencing phosphatase activity, leading to enhanced immune response coordination. | ||||||
Adenosine-5′-Diphosphate, free acid | 58-64-0 | sc-291846 sc-291846A sc-291846B sc-291846C sc-291846D sc-291846E | 100 mg 500 mg 1 g 10 g 100 g 500 g | $79.00 $184.00 $348.00 $942.00 $4688.00 $9370.00 | 1 | |
ADP, an agonist for P2Y1 and P2Y12 receptors, directly stimulates CLEC-2I by initiating calcium influx and immune response amplification. | ||||||
Collagen IV | sc-29010 | 1 mg | $224.00 | 11 | ||
Collagen, through GPVI binding, indirectly activates CLEC-2I by initiating signaling cascades that contribute to immune response coordination and cellular homeostasis. | ||||||
D-erythro-Sphingosine-1-phosphate | 26993-30-6 | sc-201383 sc-201383D sc-201383A sc-201383B sc-201383C | 1 mg 2 mg 5 mg 10 mg 25 mg | $165.00 $322.00 $570.00 $907.00 $1727.00 | 7 | |
Sphingosine-1-phosphate (S1P), an activator of S1P receptors, directly upregulates CLEC-2I, modulating cellular responses essential for immune coordination and homeostasis. | ||||||
Calpeptin | 117591-20-5 | sc-202516 sc-202516A | 10 mg 50 mg | $121.00 $456.00 | 28 | |
Calpeptin, a calpain inhibitor, indirectly activates CLEC-2I by modulating the ERK/MAPK pathway, contributing to heightened immune response coordination and cellular homeostasis. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $55.00 $131.00 $203.00 $317.00 | 23 | |
Calcium Ionophore A23187 directly activates CLEC-2I by inducing calcium influx, amplifying immune response signals crucial for cellular coordination and homeostasis. | ||||||
PGE2 | 363-24-6 | sc-201225 sc-201225C sc-201225A sc-201225B | 1 mg 5 mg 10 mg 50 mg | $57.00 $159.00 $275.00 $678.00 | 37 | |
Prostaglandin E2 (PGE2), through EP receptor activation, directly stimulates CLEC-2I, modulating cellular responses crucial for immune coordination and homeostasis. | ||||||