claudin-7 Activators
Claudin-7 activators represent a diverse group of chemicals that can influence the expression or activity of claudin-7, a protein integral to tight junctions in epithelial cells. Phorbol 12-myristate and its analog, Tetradecanoylphorbol acetate, directly activate claudin-7, leading to elevated expression in certain cell lines. These compounds belong to the phorbol ester family and are known for their capacity to modulate protein kinase C (PKC) activity, which can indirectly influence the expression of various proteins including claudin-7. Forskolin and 8-Br-cAMP are agents that affect the cellular levels of cyclic AMP (cAMP). Forskolin acts by increasing cAMP production, while 8-Br-cAMP is an analog of cAMP. The elevated cAMP levels lead to a series of intracellular events that can upregulate claudin-7 expression.
On the other hand, metals like zinc play a more foundational role, being essential for various biological processes and demonstrating an ability to enhance claudin-7 protein levels under specific conditions. LPA, or lysophosphatidic acid, modulates claudin-7 expression through its downstream effectors, while agents such as resveratrol, sodium butyrate, and isoflavone elevate claudin-7 levels by modifying transcriptional and post-transcriptional processes. Epigallocatechin gallate, a primary component of green tea extract, and genistein, a soy-derived isoflavone, also have the capacity to elevate claudin-7 expression. Lastly, baicalin, a flavonoid found in the Scutellaria plant, enhances claudin-7 expression, underscoring the potential influence of naturally-derived compounds on cellular tight junction dynamics.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
Direct activator, elevating claudin-7 expression in certain cell lines. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Increases cAMP levels, which can then elevate claudin-7 expression. | ||||||
8-Bromo-cAMP | 76939-46-3 | sc-201564 sc-201564A | 10 mg 50 mg | $126.00 $328.00 | 30 | |
cAMP analog that can elevate claudin-7 expression. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $48.00 | ||
Essential metal that can enhance claudin-7 protein levels in certain contexts. | ||||||
Lysophosphatidic Acid | 325465-93-8 | sc-201053 sc-201053A | 5 mg 25 mg | $98.00 $341.00 | 50 | |
Indirectly modulates claudin-7 expression via downstream effectors. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Polyphenol that can upregulate claudin-7 expression. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $31.00 $47.00 $84.00 $222.00 | 19 | |
Histone deacetylase inhibitor, can increase claudin-7 expression. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
Green tea extract, can increase claudin-7 protein levels. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $45.00 $164.00 $200.00 $402.00 $575.00 $981.00 $2031.00 | 46 | |
Soy-derived isoflavone, can elevate claudin-7 expression. | ||||||
Baicalin | 21967-41-9 | sc-204638 sc-204638A sc-204638B sc-204638C | 1 mg 25 mg 1 g 5 g | $56.00 $112.00 $224.00 $265.00 | 4 | |
Flavonoid found in Scutellaria, can enhance claudin-7 expression. | ||||||