CKR-7 Activators
CKR-7, also known as CCR7, plays a crucial role in orchestrating immune cell migration and homing to lymphoid tissues. The group of compounds collectively referred to as CKR-7 activators serves as a diverse set of agents that directly or indirectly enhance the functional activity of CKR-7, providing a targeted approach to modulate immune cell behavior. Forskolin, by elevating cAMP levels, positively modulates CKR-7 signaling, contributing to immune cell migration. Retinoic acid, on the other hand, enhances CKR-7 expression, providing additional binding sites for ligands and augmenting its functional activity. S1P, serving as a natural ligand for CKR-7, intricately contributes to the regulation of immune cell trafficking, adding another layer of complexity to the modulation of CKR-7 activity.
PGE2 stands out as an activator that directly promotes immune cell migration by activating CKR-7. Additionally, a positive allosteric modulator binds to an allosteric site on CKR-7, enhancing its activity in a targeted manner. A GSK-3 inhibitor indirectly boosts CKR-7 activity by influencing the Wnt signaling pathway, while a PI3K activator targets CKR-7-mediated signaling pathways, amplifying downstream cascades. Moreover, a CXCR4 inhibitor indirectly enhances CKR-7 by disrupting negative regulation imposed by shared signaling pathways. Together, these CKR-7 activators provide valuable tools for researchers to modulate immune cell migration selectively, offering insights into potential strategies for regulating immune responses and lymphoid tissue homing.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Pertussis Toxin (islet-activating protein) | 70323-44-3 | sc-200837 | 50 µg | $442.00 | 3 | |
PTX inhibits G protein-coupled receptor signaling, including CKR-7. By preventing G protein activation downstream of CKR-7, PTX indirectly enhances CKR-7 functional activity. This compound disrupts the negative regulation of CKR-7 signaling, leading to increased responsiveness to its ligands. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin activates adenylate cyclase, leading to increased cAMP levels. Elevated cAMP levels positively modulate CKR-7 functional activity by enhancing downstream signaling cascades. Forskolin indirectly activates CKR-7 by influencing the intracellular signaling pathways associated with CKR-7-mediated immune cell migration. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic acid, a derivative of vitamin A, enhances CKR-7 expression. Increased CKR-7 expression leads to heightened functional activity by providing more binding sites for ligands. Retinoic acid influences CKR-7 at the transcriptional level, promoting the receptor's presence on the cell surface and thus augmenting its responsiveness to chemotactic signals. | ||||||
D-erythro-Sphingosine-1-phosphate | 26993-30-6 | sc-201383 sc-201383D sc-201383A sc-201383B sc-201383C | 1 mg 2 mg 5 mg 10 mg 25 mg | $162.00 $316.00 $559.00 $889.00 $1693.00 | 7 | |
S1P activates CKR-7 by binding to its receptor. The binding of S1P induces signaling events that enhance CKR-7 functional activity, particularly in the context of immune cell migration. S1P serves as a natural ligand for CKR-7, contributing to the regulation of immune cell trafficking by modulating CKR-7 responsiveness to chemotactic signals. | ||||||
PGE2 | 363-24-6 | sc-201225 sc-201225C sc-201225A sc-201225B | 1 mg 5 mg 10 mg 50 mg | $56.00 $156.00 $270.00 $665.00 | 37 | |
PGE2 enhances CKR-7 functional activity by activating its downstream signaling pathways. Through interaction with its receptor, PGE2 induces signaling events that positively modulate CKR-7, promoting immune cell migration. The activation of CKR-7 by PGE2 contributes to the regulation of immune responses by facilitating the targeted movement of immune cells to specific tissues or inflammatory sites. | ||||||
GSK-3 Inhibitor IX | 667463-62-9 | sc-202634 sc-202634A sc-202634B | 1 mg 10 mg 50 mg | $57.00 $184.00 $867.00 | 10 | |
A GSK-3 inhibitor indirectly enhances CKR-7 activity by influencing the Wnt signaling pathway. GSK-3 negatively regulates Wnt signaling, which in turn modulates CKR-7 expression. Inhibition of GSK-3 leads to increased Wnt signaling, promoting CKR-7 expression and functional activity. This indirect modulation provides a link between the Wnt pathway and CKR-7 activation, influencing immune cell migration. | ||||||
WZ811 | 55778-02-4 | sc-296701 sc-296701A | 1 mg 5 mg | $29.00 $66.00 | ||
WZ811 indirectly enhances CKR-7 activity by influencing shared signaling pathways. CKR-7 and CXCR4 are involved in overlapping signaling cascades, and inhibition of CXCR4 leads to increased CKR-7 activity. The inhibitor disrupts the negative regulation imposed by CXCR4 on CKR-7, resulting in heightened functional activity and promoting immune cell migration through CKR-7-mediated pathways. | ||||||