CHT1 Activators
CHT1 (Solute Carrier Family 5 Member 7) activators belong to a distinct class of chemical compounds that have gained significance in the realm of molecular biology and pharmacology. CHT1, also known as the high-affinity choline transporter 1, is a membrane protein encoded by the SLC5A7 gene, and it plays a pivotal role in the transportation of choline, a crucial nutrient, across cell membranes. Choline is essential for a myriad of biological processes, including neurotransmitter synthesis, membrane structure maintenance, and one-carbon metabolism. The activation of CHT1 by specific ligands or activators has emerged as a subject of profound interest due to its implications in understanding cellular and molecular mechanisms related to choline uptake and transport.
CHT1 activators, through their interaction with the CHT1 protein, modulate choline transport, which can influence the availability of choline within cells. This, in turn, may have downstream effects on various cellular functions, such as acetylcholine synthesis in neurons, phospholipid production in cell membranes, and methylation reactions involved in gene regulation and overall metabolic processes. Understanding CHT1 activators is not only essential for unraveling the intricacies of choline metabolism but also for exploring their roles in the development of research tools. These compounds could serve as valuable molecular probes for investigating choline-related pathways and may offer insights into the broader field of membrane transport biology.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin is a natural compound that directly activates SLC5A7 (CHT1) by increasing cAMP levels, which, in turn, enhances the transport of iodide into thyroid cells, ultimately activating thyroid function. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $260.00 $350.00 $500.00 | 34 | |
IBMX indirectly activates SLC5A7 (CHT1) by inhibiting cAMP phosphodiesterase, leading to elevated cAMP levels that enhance the iodide transport function of SLC5A7 within thyroid cells. | ||||||
L-Thyroxine, free acid | 51-48-9 | sc-207813 sc-207813A | 100 mg 500 mg | $35.00 $74.00 | 2 | |
Levothyroxine directly activates SLC5A7 (CHT1) by providing a synthetic form of the thyroid hormone T4, thus increasing thyroid hormone production and iodide transport. | ||||||
L-3,3′,5-Triiodothyronine, free acid | 6893-02-3 | sc-204035 sc-204035A sc-204035B | 10 mg 100 mg 250 mg | $41.00 $77.00 $153.00 | ||
Liothyronine directly activates SLC5A7 (CHT1) by supplying a synthetic form of the thyroid hormone T3, enhancing the transport of iodide into thyroid cells and activating thyroid function. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $28.00 $38.00 | 5 | |
Isoproterenol indirectly activates SLC5A7 (CHT1) by activating beta-adrenergic receptors, activating thyroid function, and the activity of CHT1 through adrenergic pathways. | ||||||
Dobutamine | 34368-04-2 | sc-507555 | 100 mg | $295.00 | ||
Dobutamine indirectly activates SLC5A7 (CHT1) through beta-adrenergic activation, potentially activating the activity of CHT1 within thyroid cells. | ||||||
Theophylline | 58-55-9 | sc-202835 sc-202835A sc-202835B | 5 g 25 g 100 g | $20.00 $32.00 $85.00 | 6 | |
Theophylline indirectly activates SLC5A7 (CHT1) by inhibiting cAMP phosphodiesterase, which elevates cAMP levels and indirectly activates the activity of CHT1 within the thyroid. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $77.00 $216.00 | 18 | |
Rolipram indirectly activates SLC5A7 (CHT1) by inhibiting cAMP phosphodiesterase, leading to increased cAMP levels that may indirectly activate CHT1 activity within thyroid cells. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA indirectly activates SLC5A7 (CHT1) by directly activating protein kinase C (PKC), potentially activating thyroid function and the activity of CHT1 through PKC signaling pathways. | ||||||