CHST1 Inhibitors
CHST1 inhibitors comprise a set of compounds capable of inhibiting the activity of Carbohydrate (Keratan Sulfate Gal-6) Sulfotransferase 1 (CHST1). This enzyme is involved in the sulfation of keratan, a crucial step in the biosynthesis of glycosaminoglycans. By inhibiting CHST1, these compounds can potentially interfere with glycosaminoglycan biosynthesis. CHST1 inhibitors includes compounds that can directly block the enzyme's active site. By binding to the active site of CHST1, these compounds prevent the enzyme from interacting with its substrate, thereby inhibiting its function.
CHST1 inhibitors includes compounds that can interfere with the availability of the CHST1 substrate or the universal sulfate donor, PAPS (Adenosine-3'-phosphate 5'-phosphosulfate). These compounds could either reduce the levels of the substrate available for interaction with CHST1 or block the availability of PAPS, indirectly inhibiting the function of CHST1. For instance, compounds that can chelate sulfate ions or compete with the substrate for binding to CHST1 might fall into this category.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Sodium chlorate | 7775-09-9 | sc-212938 | 100 g | $59.00 | 1 | |
Sodium Chlorate inhibits the ATP sulfurylase, affecting the biosynthesis of 3'-phosphoadenosine 5'-phosphosulfate (PAPS), which is the sulfate donor in the reaction catalyzed by CHST1. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
Quercetin is a flavonoid that has been shown to inhibit various sulfotransferases. Though not specific to CHST1, it can potentially inhibit its activity. | ||||||
DHEA | 53-43-0 | sc-202573 | 10 g | $111.00 | 3 | |
Dehydroepiandrosterone (DHEA) is a steroid hormone that has been shown to inhibit various sulfotransferases, potentially including CHST1. | ||||||
Triclosan | 3380-34-5 | sc-220326 sc-220326A | 10 g 100 g | $141.00 $408.00 | ||
Triclosan is an antimicrobial agent that can inhibit various sulfotransferases, potentially including CHST1. | ||||||
Imatinib | 152459-95-5 | sc-267106 sc-267106A sc-267106B | 10 mg 100 mg 1 g | $26.00 $119.00 $213.00 | 27 | |
Imatinib is a tyrosine kinase inhibitor that can indirectly affect CHST1 by inhibiting signaling pathways that regulate its expression or activity. | ||||||
Nilotinib | 641571-10-0 | sc-202245 sc-202245A | 10 mg 25 mg | $209.00 $413.00 | 9 | |
Nilotinib is a tyrosine kinase inhibitor that can indirectly affect CHST1 by inhibiting signaling pathways that regulate its expression or activity. | ||||||
Dasatinib | 302962-49-8 | sc-358114 sc-358114A | 25 mg 1 g | $70.00 $145.00 | 51 | |
Dasatinib is a tyrosine kinase inhibitor that can indirectly affect CHST1 by inhibiting signaling pathways that regulate its expression or activity. | ||||||
Sunitinib, Free Base | 557795-19-4 | sc-396319 sc-396319A | 500 mg 5 g | $153.00 $938.00 | 5 | |
Sunitinib is a tyrosine kinase inhibitor that can indirectly affect CHST1 by inhibiting signaling pathways that regulate its expression or activity. | ||||||
Sorafenib | 284461-73-0 | sc-220125 sc-220125A sc-220125B | 5 mg 50 mg 500 mg | $57.00 $100.00 $250.00 | 129 | |
Sorafenib is a tyrosine kinase inhibitor that can indirectly affect CHST1 by inhibiting signaling pathways that regulate its expression or activity. | ||||||