CHMP7 Activators
CHMP7 activators are a distinct class of chemical compounds that directly or indirectly enhance the functional activity of CHMP7, a key component of the endosomal sorting complex required for transport (ESCRT-III). These compounds act by precisely interfacing with the signaling pathways or biological processes that CHMP7 is explicitly involved in.
Compounds such as ML-9, Cytochalasin D, Wortmannin, LY294002, PIK-93, Chlorpromazine, Genistein, Brefeldin A, and Monensin make up the rest of the class. Each compound, in its unique way, affects different aspects of the ESCRT pathway or other related pathways, leading to enhanced functional activity of CHMP7. Genistein, a tyrosine kinase inhibitor, impacts endocytosis and multivesicular body formation processes, leading to an enhancement of CHMP7 activity.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
ML-9 | 105637-50-1 | sc-200519 sc-200519A sc-200519B sc-200519C | 10 mg 50 mg 100 mg 250 mg | $112.00 $449.00 $673.00 $1224.00 | 2 | |
ML-9 is a myosin light chain kinase inhibitor which can disrupt actin dynamics. Alterations in actin dynamics can influence the ESCRT pathway where CHMP7 is involved, leading to enhanced activity of CHMP7. | ||||||
Cytochalasin D | 22144-77-0 | sc-201442 sc-201442A | 1 mg 5 mg | $165.00 $486.00 | 64 | |
Cytochalasin D inhibits actin polymerization, which can disrupt the normal dynamics of the actin cytoskeleton, influencing the ESCRT pathway and potentially enhancing the activity of CHMP7. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
Wortmannin is a PI3K inhibitor. PI3K is involved in multiple cellular processes including endocytosis and the formation of multivesicular bodies, both of which involve the ESCRT machinery. Inhibition of PI3K by Wortmannin could therefore enhance the activity of CHMP7. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY294002 is also a PI3K inhibitor. By inhibiting PI3K, LY294002 can influence endocytosis and multivesicular body formation, potentially enhancing CHMP7 activity. | ||||||
PIK-93 | 593960-11-3 | sc-364588 | 5 mg | $255.00 | ||
PIK-93 is a PI4K inhibitor. PI4K is involved in the formation of PI4P, a lipid that is crucial for the recruitment of ESCRT machinery to the membrane. By inhibiting PI4K, PIK-93 could enhance the activity of CHMP7. | ||||||
Chlorpromazine | 50-53-3 | sc-357313 sc-357313A | 5 g 25 g | $61.00 $110.00 | 21 | |
Chlorpromazine can induce the formation of intracellular vesicles and alter endocytic pathways. These alterations can influence the ESCRT machinery and potentially enhance the activity of CHMP7. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $45.00 $164.00 $200.00 $402.00 $575.00 $981.00 $2031.00 | 46 | |
Genistein is a tyrosine kinase inhibitor that can influence endocytosis and multivesicular body formation, potentially enhancing the activity of CHMP7. | ||||||
Brefeldin A | 20350-15-6 | sc-200861C sc-200861 sc-200861A sc-200861B | 1 mg 5 mg 25 mg 100 mg | $31.00 $53.00 $124.00 $374.00 | 25 | |
Brefeldin A disrupts the structure and function of the Golgi apparatus, which can indirectly influence the ESCRT pathway and potentially enhance the activity of CHMP7. | ||||||
Monensin A | 17090-79-8 | sc-362032 sc-362032A | 5 mg 25 mg | $155.00 $525.00 | ||
Monensin is a sodium ionophore that influences vesicular trafficking, which can affect the ESCRT pathway and potentially enhance the activity of CHMP7. | ||||||