CHCHD1 Activators
CHCHD1 activators comprise a heterogeneous collection of compounds that influence CHCHD1 function through various mechanisms, predominantly related to the modulation of oxidative stress responses, endoplasmic reticulum (ER) stress responses, and metabolic stress responses. Several of these compounds, such as Cobalt(II) chloride and Sodium arsenite, operate through the activation of stress response pathways, leading to the transcriptional upregulation of CHCHD1, which in turn enhances its functional activity. Cobalt(II) chloride induces a hypoxic response through HIF-1α stabilization, upregulating the transcription of CHCHD1. Sodium arsenite, on the other hand, induces oxidative stress that leads to the activation of the NRF2 pathway, which subsequently upregulates CHCHD1.
Other CHCHD1 activators work by inducing ER stress or metabolic stress. Tunicamycin, Thapsigargin, Verapamil, Salubrinal, and TUDCA all induce ER stress, triggering the unfolded protein response (UPR) pathway in which CHCHD1 is involved, leading to enhanced CHCHD1 activity. The induction of metabolic stress, through compounds such as 2-Deoxy-D-glucose, Rapamycin, Metformin, AICAR, and Phenformin, enhances the transcription of CHCHD1 by activating AMPK. These compounds inhibit glycolysis or mTOR, or directly activate AMPK, enhancing CHCHD1 activity. Importantly, all these compounds induce specific stress responses or changes in cellular metabolic status that necessitate the increased activity of CHCHD1, rather than simply upregulating its expression.
Items 1 to 10 of 12 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Cobalt(II) chloride | 7646-79-9 | sc-252623 sc-252623A | 5 g 100 g | $64.00 $176.00 | 7 | |
Cobalt(II) chloride is a hypoxia-mimetic agent that can stabilize HIF-1α, a transcription factor that upregulates CHCHD1 expression under low oxygen conditions. Stabilization of HIF-1α enhances the transcription of CHCHD1, leading to increased protein activity. | ||||||
Sodium (meta)arsenite | 7784-46-5 | sc-250986 sc-250986A | 100 g 1 kg | $108.00 $780.00 | 3 | |
Sodium arsenite induces oxidative stress in cells, which can stimulate the NRF2 pathway. NRF2 activation leads to the transcription of antioxidant response genes, including CHCHD1. This results in increased CHCHD1 activity, which contributes to cellular defense against oxidative stress. | ||||||
Tunicamycin | 11089-65-9 | sc-3506A sc-3506 | 5 mg 10 mg | $172.00 $305.00 | 66 | |
Tunicamycin is a glycosylation inhibitor that induces ER stress, triggering the unfolded protein response (UPR). The UPR pathway involves CHCHD1 as it plays a role in protein folding. Activation of the UPR pathway increases the functional activity of CHCHD1. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $136.00 $446.00 | 114 | |
Thapsigargin induces endoplasmic reticulum stress by inhibiting the SERCA pump, which causes calcium depletion in the ER. This activates the UPR pathway in which CHCHD1 is involved, therefore enhancing CHCHD1 activity. | ||||||
Verapamil | 52-53-9 | sc-507373 | 1 g | $374.00 | ||
Verapamil is a calcium channel blocker that affects calcium homeostasis. Changes in intracellular calcium levels can trigger ER stress and the unfolded protein response (UPR), in which CHCHD1 is involved. This leads to enhanced CHCHD1 activity. | ||||||
2-Deoxy-D-glucose | 154-17-6 | sc-202010 sc-202010A | 1 g 5 g | $70.00 $215.00 | 26 | |
2-Deoxy-D-glucose inhibits glycolysis, thereby stimulating AMPK. Activation of AMPK can enhance the transcription of CHCHD1, leading to increased protein activity. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Rapamycin inhibits mTOR, a central regulator of cell growth and proliferation. Inhibition of mTOR activates AMPK, which can enhance the transcription of CHCHD1, leading to increased protein activity. | ||||||
1,1-Dimethylbiguanide, Hydrochloride | 1115-70-4 | sc-202000F sc-202000A sc-202000B sc-202000C sc-202000D sc-202000E sc-202000 | 10 mg 5 g 10 g 50 g 100 g 250 g 1 g | $20.00 $43.00 $63.00 $156.00 $260.00 $510.00 $31.00 | 37 | |
Metformin is an AMPK activator. Activation of AMPK can enhance the transcription of CHCHD1, leading to increased protein activity. | ||||||
AICAR | 2627-69-2 | sc-200659 sc-200659A sc-200659B | 50 mg 250 mg 1 g | $65.00 $280.00 $400.00 | 48 | |
AICAR is a cell-permeable activator of AMPK. Activation of AMPK can enhance the transcription of CHCHD1, leading to increased protein activity. | ||||||
Phenformin Hydrochloride | 834-28-6 | sc-219590 | 10 g | $119.00 | 4 | |
Phenformin is an AMPK activator. Activation of AMPK can enhance the transcription of CHCHD1, leading to increased protein activity. | ||||||