CEP170 Inhibitors
CEP170 inhibitors are a class of chemical compounds that specifically target and inhibit the function of the Centrosomal Protein 170 (CEP170), a microtubule-associated protein primarily located at the centrosome. CEP170 plays a critical role in organizing microtubules during cell division and is involved in centrosome function, which is essential for maintaining the structural integrity of the mitotic spindle. The centrosome acts as the major microtubule-organizing center in animal cells, and CEP170 contributes to anchoring and stabilizing microtubules at the centrosome. Inhibition of CEP170 disrupts this process, leading to changes in microtubule dynamics, which can affect cell division and intracellular transport.
Mechanistically, CEP170 inhibitors work by binding to key regions of the protein that are responsible for its interaction with microtubules or other centrosomal components. This binding can prevent CEP170 from properly anchoring microtubules at the centrosome, leading to defects in spindle assembly during mitosis. Disrupting CEP170 function can also interfere with the overall organization of the cell's cytoskeleton, affecting processes like intracellular trafficking and cell shape maintenance. These inhibitors are valuable for studying the role of CEP170 in centrosome function and microtubule organization, providing insights into the molecular pathways that regulate cell division and structural stability. Researchers use CEP170 inhibitors to better understand the precise functions of this protein within the broader context of cell cycle regulation, particularly how it contributes to ensuring proper spindle formation and chromosome segregation during mitosis. This class of inhibitors highlights the importance of centrosomal proteins in maintaining cellular architecture and function.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Taxol | 33069-62-4 | sc-201439D sc-201439 sc-201439A sc-201439E sc-201439B sc-201439C | 1 mg 5 mg 25 mg 100 mg 250 mg 1 g | $40.00 $73.00 $217.00 $242.00 $724.00 $1196.00 | 39 | |
Taxol stabilizes microtubules and prevents their depolymerization, which indirectly inhibits CEP170 by disrupting its microtubule-associated functions, leading to a diminished capacity of CEP170 to participate in microtubule organization within the centrosome. | ||||||
Nocodazole | 31430-18-9 | sc-3518B sc-3518 sc-3518C sc-3518A | 5 mg 10 mg 25 mg 50 mg | $58.00 $83.00 $140.00 $242.00 | 38 | |
Nocodazole is a microtubule-depolymerizing agent that disrupts microtubule dynamics. By destabilizing microtubules, it reduces the functional interaction of CEP170 with microtubule ends, thus diminishing its role in microtubule stabilization and organization. | ||||||
Colchicine | 64-86-8 | sc-203005 sc-203005A sc-203005B sc-203005C sc-203005D sc-203005E | 1 g 5 g 50 g 100 g 500 g 1 kg | $98.00 $315.00 $2244.00 $4396.00 $17850.00 $34068.00 | 3 | |
Colchicine binds to tubulin, inhibiting its polymerization into microtubules, thereby reducing the ability of CEP170 to anchor to microtubules and perform its stabilizing function, leading to an overall decrease in microtubule integrity at the centrosome. | ||||||
Vinblastine | 865-21-4 | sc-491749 sc-491749A sc-491749B sc-491749C sc-491749D | 10 mg 50 mg 100 mg 500 mg 1 g | $100.00 $230.00 $450.00 $1715.00 $2900.00 | 4 | |
Vinblastine disrupts microtubule assembly by binding to tubulin, therefore indirectly diminishing the role of CEP170 in microtubule guidance and stabilization, which is crucial for its function in cellular processes like intracellular transport and cell division. | ||||||
Eribulin | 253128-41-5 | sc-507547 | 5 mg | $865.00 | ||
Eribulin inhibits microtubule growth by binding to the plus ends, diminishing the interaction between microtubules and CEP170, and thereby reducing the stabilizing and organizing effect of CEP170 on microtubule architecture. | ||||||
Podophyllotoxin | 518-28-5 | sc-204853 | 100 mg | $82.00 | 1 | |
Podophyllotoxin binds to tubulin and inhibits its polymerization, leading to a reduced association of CEP170 with microtubules and a consequent decrease in the functional activity of CEP170 in microtubule organization and spindle assembly. | ||||||
Griseofulvin | 126-07-8 | sc-202171A sc-202171 sc-202171B | 5 mg 25 mg 100 mg | $83.00 $216.00 $586.00 | 4 | |
Griseofulvin disrupts microtubule function by interfering with microtubule polymerization. This impedes the ability of CEP170 to bind to and stabilize microtubules, hence diminishing its role in mitotic spindle organization and cellular transport. | ||||||
Parthenolide | 20554-84-1 | sc-3523 sc-3523A | 50 mg 250 mg | $79.00 $300.00 | 32 | |
Parthenolide has been shown to disrupt microtubule dynamics. Although not a direct inhibitor of CEP170, by affecting microtubules, it indirectly diminishes CEP170's role in centrosomal cohesion and microtubule nucleation. | ||||||
2-Methoxyestradiol | 362-07-2 | sc-201371 sc-201371A | 10 mg 50 mg | $70.00 $282.00 | 6 | |
2-Methoxyestradiol binds to tubulin at the colchicine site, leading to microtubule destabilization. This diminishes CEP170's microtubule-stabilizing activity, indirectly reducing its functional role in maintaining centrosome integrity. | ||||||
Combrestatin A4 | 117048-59-6 | sc-204697 sc-204697A | 1 mg 5 mg | $45.00 $79.00 | ||
Combretastatin A4 binds to tubulin at the colchicine site, inhibiting microtubule polymerization. The disruption of microtubule formation indirectly leads to a decrease in CEP170's ability to stabilize microtubules and support centrosomal and spindle functions. | ||||||