Cdc53 Inhibitors
Cdc53 inhibitors belong to a distinct chemical class that interacts with and modulates the activity of the Cdc53 protein. This protein, also known as Cullin 1, is a key component of the SCF (Skp1-Cullin 1-F-box protein) E3 ubiquitin ligase complex, which plays a pivotal role in regulating the targeted degradation of specific proteins through the ubiquitin-proteasome pathway. Cdc53, as an integral part of this complex, acts as a scaffold protein, facilitating the assembly of the SCF complex and enabling the recognition and ubiquitination of substrate proteins for subsequent proteasomal degradation.
Inhibitors targeting Cdc53 are designed to selectively interfere with its function, thereby impacting the assembly and overall activity of the SCF E3 ligase complex. By perturbing this process, Cdc53 inhibitors offer a means to modulate the degradation of target proteins, potentially leading to altered cellular pathways and processes. The development and study of Cdc53 inhibitors contribute to a deeper understanding of intracellular protein degradation mechanisms and hold promise for broader insights into cellular regulatory networks.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
MLN 4924 | 905579-51-3 | sc-484814 | 1 mg | $286.00 | 1 | |
MLN4924 is a small molecule inhibitor that targets the NEDD8-activating enzyme (NAE), which is responsible for activating NEDD8, a protein that modifies Cullin proteins in the CRL complex. Inhibiting NAE prevents proper functioning of CRLs and thus affects protein degradation pathways. | ||||||
Cisplatin | 15663-27-1 | sc-200896 sc-200896A | 100 mg 500 mg | $138.00 $380.00 | 101 | |
While primarily known as a chemotherapeutic agent, cisplatin has been shown to inhibit Cullin-1 and disrupt CRL activity, contributing to its anti-cancer effects. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
A natural compound found in turmeric, curcumin has been reported to inhibit Cullin-RING E3 ubiquitin ligases, leading to the stabilization of certain proteins targeted for degradation. | ||||||
MLN7243 | 1450833-55-2 | sc-507338 | 5 mg | $340.00 | ||
This is another analog of MLN4924 that has been investigated for its CDC53/CRL inhibitory properties. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $153.00 $292.00 $489.00 $1325.00 $8465.00 $933.00 | 22 | |
A natural compound found in cruciferous vegetables, sulforaphane has been investigated for its ability to inhibit Cullin-RING E3 ubiquitin ligases and potentially exert anti-cancer effects. | ||||||