CCDC11 Activators
CCDC11 activators encompass a diverse set of chemical compounds that target various cellular signaling pathways and processes. Vorinostat, for instance, by inhibiting histone deacetylases, could indirectlyAs the task requires discussing chemical compounds that could enhance the functional activity of CCDC11, the chemicals listed are chosen based on their influence on cellular pathways that are either directly or indirectly related to the functions typically associated with coiled-coil domain-containing proteins. It is important to note that while the direct activators of CCDC11 are not established, the compounds have been selected based on logical connections to the broader cellular processes that CCDC11 may influence.
Vorinostat acts as an HDAC inhibitor, enhancing the acetylation of histones, which may lead to increased accessibility of chromatin for DNA repair proteins. Given that CCDC11 may have a role in the DNA damage response, vorinostat could indirectly enhance CCDC11's activity by promoting a more robust DNA repair environment. Roscovitine, a CDK inhibitor, also touches upon the DNA repair process by allowing more time for the cell to execute repair mechanisms, potentially enhancing CCDC11's presumed role in this area. KU-55933, as an ATM kinase inhibitor, might modulate the DNA damage response in a way that compensates for ATM inhibition by upregulating CCDC11's activity if it is part of that response network.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $130.00 $270.00 | 37 | |
Vorinostat is an HDAC inhibitor that can enhance the acetylation of histones, leading to the unwinding of DNA and potentially increasing the access of DNA repair machinery. Enhanced DNA repair processes can indirectly increase the functional activity of CCDC11 if it is involved in this pathway. | ||||||
Roscovitine | 186692-46-6 | sc-24002 sc-24002A | 1 mg 5 mg | $92.00 $260.00 | 42 | |
Roscovitine is a CDK inhibitor that can lead to cell cycle arrest, providing more time for the cell to engage in repair mechanisms. If CCDC11 is part of the DNA damage response, the presence of Roscovitine could indirectly enhance CCDC11's activity by prolonging the window for repair. | ||||||
ATM Kinase Inhibitor | 587871-26-9 | sc-202963 | 2 mg | $108.00 | 28 | |
KU-55933 is an ATM kinase inhibitor. By inhibiting ATM, the DNA damage response is modulated. If CCDC11 functions downstream of ATM activation, inhibiting ATM can lead to a compensatory upregulation of CCDC11's activity. | ||||||
ZM-447439 | 331771-20-1 | sc-200696 sc-200696A | 1 mg 10 mg | $150.00 $349.00 | 15 | |
ZM447439 is an Aurora kinase inhibitor, which disrupts mitotic spindle formation. If CCDC11 plays a role in cell division or ciliogenesis, inhibiting Aurora kinase could indirectly enhance CCDC11's functional activity by impacting microtubule dynamics. | ||||||
ML-7 hydrochloride | 110448-33-4 | sc-200557 sc-200557A | 10 mg 50 mg | $89.00 $262.00 | 13 | |
ML-7 is a myosin light chain kinase inhibitor. If CCDC11 is involved in cytoskeletal organization, inhibition of myosin light chain kinase could lead to changes in cytoskeletal dynamics that indirectly enhance CCDC11's activity in processes such as ciliogenesis. | ||||||
Chloroquine Sulphate | 132-73-0 | sc-337629 | 25 mg | $224.00 | 2 | |
Chloroquine is known to alkalinize lysosomes and inhibit autophagy. If CCDC11 is involved in autophagic processes or lysosome function, Chloroquine could enhance the functional activity of CCDC11 by modulating these processes. | ||||||
PF 4708671 | 1255517-76-0 | sc-361288 sc-361288A | 10 mg 50 mg | $175.00 $700.00 | 9 | |
PF-4708671 is a p70 S6 Kinase inhibitor, which can affect protein synthesis and cell growth. If CCDC11 has a role in growth-related signaling pathways, inhibiting p70 S6 Kinase might enhance CCDC11's functional activity by altering these pathways. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 is a JNK inhibitor. JNK is involved in stress response pathways and apoptosis. If CCDC11 operates within these pathways, inhibiting JNK can enhance CCDC11's functional activity by affecting stress response signaling. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $182.00 $693.00 | 88 | |
Y-27632 is a ROCK inhibitor that affects actin cytoskeleton organization. This can lead to changes in cellular morphology. If CCDC11 is implicated in cellular structure or motility, inhibition of ROCK may enhance its activity. | ||||||
DNA-PK Inhibitor II | 154447-35-5 | sc-202143 sc-202143A | 10 mg 50 mg | $155.00 $660.00 | 6 | |
NU7026 is a DNA-PK inhibitor. DNA-PK is involved in the non-homologous end joining pathway of DNA repair. If CCDC11 is involved in DNA repair, inhibiting DNA-PK could lead to the upregulation of alternative repair pathways, potentially enhancing CCDC11's activity. | ||||||