CCDC11 Inhibitors
CCDC11 Inhibitors are a range of chemicals that can interfere with the specific signaling pathways or biological processes that CCDC11 is involved in, leading to a decrease in its functional activity. CCDC11 is primarily associated with ciliary function, and thus, the inhibitors that can impact ciliary function are considered as potential CCDC11 inhibitors. Genistein, U0126, Quercetin, LY294002, PD98059, Wortmannin, Apigenin, Resveratrol, EGCG, SB203580, SP600125, and Curcumin are the chemicals that can potentially act as CCDC11 inhibitors through their effects on EGFR, ERK, PI3K/AKT, and JNK pathways, which are implicated in the regulation of cilia length and assembly.
Genistein, an EGFR inhibitor, canalter ciliary length, thereby impacting CCDC11 activity. U0126, a MEK1/2 inhibitor, impairs the ERK pathway, which is connected to ciliary disassembly, hence affecting CCDC11 activity. Quercetin, LY294002, Wortmannin, Apigenin, Resveratrol, and EGCG act by inhibiting the PI3K/AKT pathway, which is known to have a role in cilia length control. As such, these inhibitors can influence the activity of CCDC11, which is essential for cilia function. PD98059, another MEK inhibitor, dampens the ERK/MAPK pathway, which is involved in cilia disassembly, thereby impacting CCDC11 activity. Finally, SB203580, SP600125, and Curcumin inhibit the p38 MAPK and JNK pathways, respectively.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $45.00 $164.00 $200.00 $402.00 $575.00 $981.00 $2031.00 | 46 | |
Genistein inhibits EGFR. EGFR signaling pathway is known to regulate the ciliary length, and CCDC11 is associated with the ciliary function. Thus, Genistein's inhibition of EGFR can lead to changes in ciliary length, impacting CCDC11 activity. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
Quercetin is a PI3K inhibitor. PI3K signaling is linked to cilia length control, and as CCDC11 is involved in cilia function, Quercetin's inhibition of PI3K can affect CCDC11 activity. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY294002 inhibits PI3K, which is crucial in the PI3K/AKT signaling pathway. The PI3K/AKT pathway is involved in cilia length control, and as CCDC11 is essential for cilia function, LY294002 can impact CCDC11 activity. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $40.00 $92.00 | 212 | |
PD98059 is a MEK inhibitor, specifically inhibiting the ERK/MAPK pathway. The ERK/MAPK pathway is involved in cilia disassembly, and CCDC11 is crucial for ciliary function. Therefore, PD98059's inhibition of this pathway can affect CCDC11 activity. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
Wortmannin is a PI3K inhibitor. PI3K signaling is linked to cilia length control, and as CCDC11 is involved in ciliary function, Wortmannin's inhibition of PI3K can impact CCDC11 activity. | ||||||
Apigenin | 520-36-5 | sc-3529 sc-3529A sc-3529B sc-3529C sc-3529D sc-3529E sc-3529F | 5 mg 100 mg 1 g 5 g 25 g 100 g 1 kg | $33.00 $214.00 $734.00 $1151.00 $2348.00 $3127.00 $5208.00 | 22 | |
Apigenin inhibits PI3K/AKT pathway, which is involved in cilia length control. CCDC11 is essential for ciliary function, thus, Apigenin's inhibition of the PI3K/AKT pathway can affect CCDC11 activity. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol inhibits the PI3K/AKT pathway. Since CCDC11 is involved in cilia function, which is regulated by the PI3K/AKT pathway, Resveratrol's inhibition of the PI3K/AKT pathway can impact CCDC11 activity. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
EGCG inhibits the PI3K/AKT pathway. As CCDC11 is essential for ciliary function, which is regulated by the PI3K/AKT pathway, EGCG's inhibition of the PI3K/AKT pathway can impact CCDC11 activity. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $90.00 $349.00 | 284 | |
SB203580 is an inhibitor of p38 MAPK. The p38 MAPK pathway is linked to ciliary disassembly, and CCDC11 is crucial for ciliary function. Therefore, SB203580's inhibition of the p38 MAPK pathway can affect CCDC11 activity. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin inhibits JNK and p38 MAPK signaling pathways, both of which are linked to ciliary disassembly. As CCDC11 is essential for ciliary function, Curcumin's inhibition of these pathways can influence CCDC11 activity. | ||||||