CBARA1 (MICU1) Inhibitors
MICU1, or Mitochondrial Calcium Uptake 1, plays a pivotal role in calcium signaling within cells, particularly in the context of mitochondrial function. MICU1 is a vital component of the mitochondrial calcium uniporter (MCU) complex, which is responsible for calcium uptake into the mitochondria. Proper regulation of calcium ions in the mitochondria is crucial for various cellular processes, including energy metabolism and signaling cascades. Disruption in mitochondrial calcium homeostasis can have profound consequences, leading to cellular dysfunction and various pathological conditions.
Inhibitors targeting MICU1 aim to modulate mitochondrial calcium uptake by altering the function of MICU1. By inhibiting MICU1, these molecules can potentially regulate the entry of calcium ions into the mitochondria, thus affecting the concentration of calcium within this organelle. The nature of MICU1 inhibitors can be varied, ranging from small organic molecules to peptides or even larger biomolecules. Their mechanism of action could involve direct binding to MICU1, thereby altering its conformation and function, or they might act indirectly by modulating the interaction between MICU1 and other components of the MCU complex. Some inhibitors may MICU1 from interacting with the uniporter channel, while others might change the sensitivity of MICU1 to calcium, affecting its gatekeeping role.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
KB-R7943 MESYLATE | 182004-65-5 | sc-202681 | 10 mg | $160.00 | 4 | |
KB-R7943 is a non-selective inhibitor of the Na+/Ca2+ exchanger, which is involved in calcium exchange between the cytosol and mitochondria. By modulating cytosolic calcium levels, KB-R7943 can indirectly affect MICU1 and mitochondrial calcium handling. | ||||||
CGP 37157 | 75450-34-9 | sc-202097 sc-202097A | 5 mg 25 mg | $115.00 $463.00 | 3 | |
CGP-37157 is a compound that inhibits the mitochondrial Na+/Ca2+ exchanger, which indirectly affects the regulation of mitochondrial calcium by MICU1. | ||||||
Cyclosporin A | 59865-13-3 | sc-3503 sc-3503-CW sc-3503A sc-3503B sc-3503C sc-3503D | 100 mg 100 mg 500 mg 10 g 25 g 100 g | $63.00 $92.00 $250.00 $485.00 $1035.00 $2141.00 | 69 | |
Cyclosporin A is an immunosuppressive drug that can indirectly affect MICU1 activity. It inhibits the opening of the mitochondrial permeability transition pore (mPTP), which modulates calcium dynamics and can impact the regulatory function of MICU1. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $136.00 $446.00 | 114 | |
Thapsigargin is a natural compound found in the plant Thapsia garganica. While its primary target is the sarco/endoplasmic reticulum calcium ATPase (SERCA), it indirectly affects mitochondrial calcium handling and can impact MICU1 activity. | ||||||
CGS 9343B | 109826-27-9 | sc-203883 | 10 mg | $320.00 | ||
CGS-9343B is a compound that inhibits the mitochondrial Na+/Ca2+ exchanger, indirectly affecting MICU1-mediated calcium regulation. | ||||||
2-APB | 524-95-8 | sc-201487 sc-201487A | 20 mg 100 mg | $28.00 $53.00 | 37 | |
2-APB is a widely used inhibitor of various calcium channels, including the inositol 1,4,5-trisphosphate receptor (IP3R). By modulating intracellular calcium levels, it can indirectly affect MICU1 function. | ||||||
Carvedilol | 72956-09-3 | sc-200157 sc-200157A sc-200157B sc-200157C sc-200157D | 100 mg 1 g 10 g 25 g 100 g | $124.00 $240.00 $530.00 $999.00 $1530.00 | 2 | |
Carvedilol is an agent in research primarily used for high blood pressure and heart failure. It has been reported to modulate mitochondrial calcium handling and can indirectly affect MICU1 activity. | ||||||
Naringenin | 480-41-1 | sc-219338 | 25 g | $245.00 | 11 | |
Naringenin is a natural flavonoid compound found in citrus fruits. It has been reported to modulate mitochondrial calcium levels and influence the activity of MICU1. | ||||||