Molecular structure of CGS 9343B, CAS Number: 109826-27-9
CGS 9343B (CAS 109826-27-9)
Alternate Names:
1,3-Dihydro-1-[1-[(4-methyl-4H,6H-pyrrolo[1,2-a][4,1]- benzoxazepin-4-yl)methyl]-4-piperidinyl]-2H-benzimidazol-2-one maleate
Application:
CGS 9343B is a CaM antagonist that inhibits CaM-stimulated cAMP phosphodiesterase activity
CAS Number:
109826-27-9
Molecular Weight:
544.60
Molecular Formula:
C26H28N4O2•C4H4O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Available in US only.
Available in US only.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
CGS 9343B is a potent and selective antagonist of the angiotensin AT1 receptor, integral to the renin-angiotensin-aldosterone system which regulates blood pressure and fluid balance. It operates through competitive binding to the AT1 receptor, thereby blocking angiotensin II from attaching and activating the receptor. This inhibition prevents the receptor from triggering pathways responsible for vasoconstriction, aldosterone secretion, and stimulation of the sympathetic nervous system. As a result, CGS 9343B disrupts the typical biological actions facilitated by angiotensin II.
CGS 9343B (CAS 109826-27-9) References
- IQGAP1 and calmodulin modulate E-cadherin function. | Li, Z., et al. 1999. J Biol Chem. 274: 37885-92. PMID: 10608854
- Calmodulin enhances the stability of the estrogen receptor. | Li, Z., et al. 2001. J Biol Chem. 276: 17354-60. PMID: 11278648
- IQGAP1-mediated stimulation of transcriptional co-activation by beta-catenin is modulated by calmodulin. | Briggs, MW., et al. 2002. J Biol Chem. 277: 7453-65. PMID: 11734550
- Interaction of calmodulin- and PKC-dependent contractile pathways in cat lower esophageal sphincter (LES). | Kang, HY., et al. 2001. Arch Pharm Res. 24: 546-51. PMID: 11794533
- Interleukin 1beta-induced production of H2O2 contributes to reduced sigmoid colonic circular smooth muscle contractility in ulcerative colitis. | Cao, W., et al. 2004. J Pharmacol Exp Ther. 311: 60-70. PMID: 15205451
- Differential regulation by Ca(2+) of calmodulin- and PKC-dependent contractile pathways in cat lower oesophageal sphincter. | Sohn, UD., et al. 2003. Auton Autacoid Pharmacol. 23: 307-17. PMID: 15255815
- E6AP and calmodulin reciprocally regulate estrogen receptor stability. | Li, L., et al. 2006. J Biol Chem. 281: 1978-85. PMID: 16314411
- NK2 receptor-mediated spontaneous phasic contractions in normal and ulcerative colitis human sigmoid colon. | Cao, W., et al. 2006. J Pharmacol Exp Ther. 317: 1349-55. PMID: 16554357
- Calmodulin influences MAPK signaling by binding KSR1. | Parvathaneni, S., et al. 2021. J Biol Chem. 296: 100577. PMID: 33766558
- Regulation of basal autophagy by calmodulin availability. | Giles, J., et al. 2022. FEBS J. 289: 5322-5340. PMID: 35285161
- Cholecystokinin-coupled intracellular signaling in human gallbladder muscle. | Yu, P., et al. 1994. Gastroenterology. 106: 763-70. PMID: 8119547
- Effects of ethylene glycol tetraacetic acid, A23187 and calmodulin, calcium activated neutral proteinase antagonists on melatonin secretion in perifused chick pineal gland. | Agapito, MT., et al. 1998. Neurosci Lett. 245: 143-6. PMID: 9605476
- Signal transduction pathways mediating CCK-induced gallbladder muscle contraction. | Yu, P., et al. 1998. Am J Physiol. 275: G203-11. PMID: 9688646
Inhibitor of:
CALML3, CaM, and CBARA1 (MICU1).Activator of:
PMCA2.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CGS 9343B, 10 mg | sc-203883 | 10 mg | $320.00 | |||
| US: Only available in the US | ||||||