CAX1 Activators
CAX1 activators are chemicals that indirectly influence the activity of cation exchangers by modulating the cellular calcium landscape. This modulation can arise through various mechanisms, including altering the activity of calcium channels, affecting calcium ionophores, or influencing calcium stores within the cell. For instance, compounds like BAY K 8644 directly stimulate calcium channels, resulting in an influx of calcium that may upregulate CAX1 to transport excess calcium out of the cytosol. In contrast, inhibitors like cyclopiazonic acid block the reuptake of calcium into the endoplasmic reticulum, thereby raising cytosolic calcium levels and potentially necessitating the increased activity of CAX1 to maintain calcium homeostasis.
Moreover, the use of ionophores such as ionomycin and A23187 demonstrates a direct method of increasing intracellular calcium, which could signal the need for heightened CAX1 activity to rebalance intracellular calcium levels. This class also includes various calcium channel antagonists like verapamil and nifedipine, which can lead to complex changes in cellular calcium handling, potentially causing an upregulation of CAX1 function as the cell seeks to restore its normal calcium dynamics.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Cyclopiazonic Acid | 18172-33-3 | sc-201510 sc-201510A | 10 mg 50 mg | $176.00 $624.00 | 3 | |
An inhibitor of the sarcoplasmic/endoplasmic reticulum Ca2+-ATPase (SERCA), raising cytosolic calcium levels which could enhance CAX1 activity to restore homeostasis. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $78.00 $270.00 | 80 | |
A calcium ionophore that increases intracellular calcium by forming complexes with Ca2+ ions, which may indirectly necessitate increased CAX1 function. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $55.00 $131.00 $203.00 $317.00 | 23 | |
Another calcium ionophore which elevates intracellular Ca2+ and could indirectly stimulate CAX1 activity as the cell attempts to restore calcium balance. | ||||||
Nicardipine hydrochloride | 54527-84-3 | sc-202731 sc-202731A | 1 g 5 g | $33.00 $83.00 | 5 | |
A calcium channel blocker that affects cellular calcium influx and could modulate the function of CAX1 as part of calcium regulation. | ||||||
Dantrolene | 7261-97-4 | sc-500165 | 25 mg | $350.00 | 7 | |
An agent that inhibits ryanodine receptors and could indirectly affect CAX1 activity by altering intracellular calcium levels. | ||||||
Chelerythrine chloride | 3895-92-9 | sc-3547 sc-3547A | 5 mg 25 mg | $90.00 $317.00 | 17 | |
A potent inhibitor of protein kinase C, which could impact calcium signaling pathways and subsequently modulate CAX1 activity. | ||||||