Date published: 2026-6-1

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cathepsin F Activators

Cathepsin F activators represent a group of chemical substances that can stimulate the activity of cathepsin F, a cysteine protease enzyme. This enzyme is part of the cathepsin family, which is primarily localized in the lysosomes of cells. Cathepsin F is unique due to its extended proregion, which contains a cystatin-like domain, not found in other members of the cathepsin family. The activation of cathepsin F can be influenced by various factors, including pH levels, the presence of certain ions, and the interaction with other molecules or substrates. Chemical substances classified as cathepsin F activators can act directly or indirectly. Direct activators may bind to the enzyme and enhance its proteolytic activity. Indirect activators, on the other hand, can function by modifying the cellular environment or pathways in a way that fosters cathepsin F activity. For example, changes in lysosomal pH caused by lysosomotropic agents may facilitate the maturation and activity of cathepsin F. Moreover, substances that induce cellular processes like autophagy or apoptosis may also indirectly stimulate cathepsin F activity by increasing the delivery of substrates to the lysosomes or by activating pathways where cathepsin F plays a role.
Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

MG-132 [Z-Leu- Leu-Leu-CHO]

133407-82-6sc-201270
sc-201270A
sc-201270B
5 mg
25 mg
100 mg
$60.00
$265.00
$1000.00
163
(3)

MG132 is a proteasome inhibitor that can cause accumulation of proteins, potentially enhancing substrate availability for lysosomal degradation enzymes like cathepsin F.

Bortezomib

179324-69-7sc-217785
sc-217785A
2.5 mg
25 mg
$135.00
$1085.00
115
(2)

Bortezomib, a proteasome inhibitor, could stimulate cathepsin F activity indirectly by blocking protein degradation and enhancing antigen presentation pathways, in which cathepsin F is involved.

E-64

66701-25-5sc-201276
sc-201276A
sc-201276B
5 mg
25 mg
250 mg
$281.00
$947.00
$1574.00
14
(0)

E64 is a cysteine protease inhibitor. While it does not directly stimulate cathepsin F, it may alter overall protease activity in the cell, potentially boosting cathepsin F function indirectly.

Rapamycin

53123-88-9sc-3504
sc-3504A
sc-3504B
1 mg
5 mg
25 mg
$63.00
$158.00
$326.00
233
(4)

Rapamycin is an autophagy inducer. By increasing the amount of protein substrates delivered to lysosomes for degradation, it could indirectly stimulate the activity of cathepsin F.

D-(+)-Trehalose Anhydrous

99-20-7sc-294151
sc-294151A
sc-294151B
1 g
25 g
100 g
$30.00
$167.00
$260.00
2
(0)

Trehalose is an autophagy inducer. It might indirectly encourage cathepsin F activity by promoting protein substrate delivery to lysosomes.

ONX 0914

960374-59-8sc-477437
5 mg
$245.00
(0)

PR-957 inhibits the immunoproteasome, potentially promoting antigen processing pathways that involve cathepsin F.

Staurosporine

62996-74-1sc-3510
sc-3510A
sc-3510B
100 µg
1 mg
5 mg
$82.00
$153.00
$396.00
113
(4)

Staurosporine is an apoptosis inducer. As cathepsin F may be involved in apoptosis, this compound could indirectly promote cathepsin F activity.

Heparin

9005-49-6sc-507344
25 mg
$119.00
1
(0)

Heparin sulfate is a glycosaminoglycan (GAG) known to interact with various proteins. It might stimulate cathepsin F activity, though the specific mechanism is not well-understood.

Hydrogen Peroxide

7722-84-1sc-203336
sc-203336A
sc-203336B
100 ml
500 ml
3.8 L
$31.00
$61.00
$95.00
28
(1)

Hydrogen peroxide is a reactive oxygen species (ROS) producer. It might indirectly stimulate cathepsin F activity by inducing cellular stress responses, which could encourage lysosomal degradation pathways.

Ionomycin, free acid

56092-81-0sc-263405
sc-263405A
1 mg
5 mg
$96.00
$264.00
2
(2)

Ionomycin increases intracellular calcium concentration, which can activate cellular processes that might foster cathepsin F activity.