CaSR Activators
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Cinacalcet Hydrochloride | 364782-34-3 | sc-207438 | 10 mg | $230.00 | 7 | |
Cinacalcet Hydrochloride acts as a potent allosteric modulator of the calcium-sensing receptor (CaSR), influencing its conformational dynamics. By stabilizing the active state of CaSR, it enhances the receptor's sensitivity to extracellular calcium levels. This modulation alters downstream signaling pathways, particularly those involving parathyroid hormone secretion and calcium homeostasis. Its unique interaction profile allows for nuanced regulation of cellular responses to calcium fluctuations. | ||||||
R 568 hydrochloride | 177172-49-5 | sc-361302 sc-361302A | 10 mg 50 mg | $210.00 $860.00 | 4 | |
R 568 hydrochloride serves as a selective allosteric enhancer of the calcium-sensing receptor (CaSR), promoting its activation through distinct molecular interactions. This compound exhibits a unique binding affinity that fine-tunes the receptor's response to calcium ions, thereby influencing intracellular signaling cascades. Its kinetic properties facilitate rapid receptor activation, leading to enhanced modulation of calcium-related pathways, which underscores its role in cellular calcium regulation. | ||||||
AC-265347 | 1253901-26-6 | sc-364395 sc-364395A | 5 mg 25 mg | $87.00 $370.00 | 1 | |
AC-265347 functions as a potent modulator of the calcium-sensing receptor (CaSR), exhibiting a unique mechanism of action through specific allosteric binding sites. This compound engages in distinctive molecular interactions that stabilize the receptor's active conformation, thereby amplifying its sensitivity to extracellular calcium levels. The compound's dynamic kinetics enable swift receptor activation, influencing downstream signaling pathways and contributing to the intricate regulation of calcium homeostasis within cells. | ||||||
Strontium chloride | 10476-85-4 | sc-258180 | 5 g | $100.00 | ||
Strontium chloride acts as a selective modulator of the calcium-sensing receptor (CaSR), characterized by its ability to mimic calcium ions in binding affinity. This compound facilitates unique ionic interactions that enhance receptor activation, promoting a conformational shift that influences intracellular signaling cascades. Its distinct solubility properties allow for effective diffusion in biological systems, impacting the receptor's responsiveness to fluctuating calcium concentrations and modulating cellular calcium dynamics. | ||||||
Calindol hydrochloride | 729610-18-8 | sc-211006 | 10 mg | $400.00 | 8 | |
Calindol is a calcimimetic agent that acts on the CaSR, enhancing its response to extracellular calcium ions and activating the receptor. | ||||||
Calhex 231 | 652973-93-8 | sc-207394 | 5 mg | $340.00 | 16 | |
Calhex 231 is a non-peptide calcimimetic agent that selectively activates CaSR, enhancing its response to extracellular calcium. | ||||||