Cinacalcet Hydrochloride CAS: 364782-34-3
MF: C22H23ClF3N
MW: 393.87
An allosteric activator of CaSR.

Cinacalcet Hydrochloride (CAS 364782-34-3)

Cinacalcet Hydrochloride | CAS 364782-34-3 is rated 5.0 out of 5 by 1.
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Alternate Names: (αR)-α-Methyl-N-[3-[3-(trifluoromethyl)phenyl)propyl]-1-napthalenemethanamine Hydrochloride; (R)-N-(3-(3-(trifluoromethyl)phenyl)propyl)-1- -(1-napthyl)ethylamine Hydrochloride; Mimpara; Sensipar
Application: Cinacalcet Hydrochloride is an allosteric activator of CaSR
CAS Number: 364782-34-3
Purity: ≥99%
Molecular Weight: 393.87
Molecular Formula: C22H23ClF3N
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

Cinacalcet Hydrochloride is a type II calcimimetic agent which controls calcium levels in cells by allosteric activation of CaSR (calcium sensing receptors). Studies show that Cinacalcet Hydrochloride affects cell proliferation in CHO cells transfected with CaSRs. In addition, it is known that Cinacalcet Hydrochloride inhibits the secretion of the parathyroid hormone (PTH). These studies suggest that Cinacalcet Hydrochloride in instrumental in increasing the cytoplasmic concentration of Ca2+. Furthermore, Cinacalcet Hydrochloride is an analog of NPS R-568 which contains a much better metabolic profile.


References

1. Shalhoub, V., et al. 2003. Crit. Rev. Eukaryot. Gene Expr. 13: 89-106. PMID: 14696958
2. Nemeth, E.F., et al. 2004. J. Pharmacol. Exp. Ther. 308: 627-635. PMID: 14593085
3. Liou, A.P., et al. 2011. Am J Physiol Gastrointest Liver Physiol. [Epub ahead of print]. PMID: 21252045

Appearance :
Crystalline powder
Physical State :
Solid
Solubility :
Soluble in water (1 mg/ml at 25° C), DMSO (79 mg/ml at 25° C), ethanol (33 mg/ml at 25° C), and methanol.
Storage :
Store at -20° C
Melting Point :
175-177° C (dec.)
Boiling Point :
440.9° C at 760 mmHg
Refractive Index :
n20D ~1.56 (Predicted)
Optical Activity :
α20D -29.6°, c = 1 in methanol
IC50 :
CaSR: EC5050 = 19.95 nM (human); Concentration-dependent decrease in PTH levels: IC50 = 27 nM; CaSR: IC50 = 2.8 µM
pK Values :
pKa: 8.4 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
156418
MDL Number :
MFCD08067750
Beilstein Registry :
10219584
SMILES :
C[[email protected]](C1=CC=CC2=CC=CC=C21)NCCCC3=CC(=CC=C3)C(F)(F)F.Cl

Download SDS (MSDS)

Certificate of Analysis

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Cinacalcet Hydrochloride (CAS 364782-34-3)  Product Citations

See how others have used Cinacalcet Hydrochloride (CAS 364782-34-3). Click on the entry to view the PubMed entry .

Citations 1 to 6 of 6 total

PMID: # 31013259  Lee, JJ.|Liu, X.|O'Neill, D.|Beggs, MR.|Weissgerber, P.|Flockerzi, V.|Chen, XZ.|Dimke, H.|Alexander, RT.| et al. 2019. JCI Insight. 5:

PMID: # 30838870  Wu, M.|Feng, Y.|Ye, GX.|Han, YC.|Wang, SS.|Ni, HF.|Wang, FM.|Gao, M.|Lv, LL.|Liu, BC.| et al. 2019. Am. J. Physiol. Renal Physiol. 316: F1006-F1015.

PMID: # 27593220  Wu, M. et al. 2016. Acta Pharmacol. Sin. 37: 1423-1431.

PMID: # 24154694  Wu, M. et al. 2014. Am. J. Physiol. Renal Physiol. 306: F138-46.

PMID: # 24382406  Wu, M. et al. 2014. International journal of cardiology. 171: e65-9.

PMID: # 32186932  Am. J. Physiol., Cell Physiol.

Citations 1 to 6 of 6 total
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Rated 5 out of 5 by from Weekers Weekers, L. et al. (PubMed 25755835) investigated the impact of pharmacological pre-activation of the calcium-sensing receptor (CaSR) on kidney structure and function in a murine model of ischemia/reperfusion. They found that introduction of the CaSR antagonist Cinacalcet before renal ischemia/reperfusion exacerbates kidney injury. -SCBT Publication Review
Date published: 2015-05-06
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